Navigation Links
Metformin's Anti-Cancer Properties Clarified in an Obesity Cell Model of Pancreatic Cancer
Date:7/22/2013

Los Angeles, California (PRWEB) July 22, 2013

SiDMAP, LLC, a leading provider of targeted 13C tracer fate association studies and biomarker development services, announces the publication of findings that metformin inhibits carbon flux towards new fatty acid synthesis in the presence of cholesterol, a known diseases factor in obesity and diabetes, to facilitate pancreatic cancer growth. The integrated nutritional and 13C Isotopolome-Wide Association Study with cholesterol administration to pancreatic cancer cell lines, is published in the official journal of the Metabolomics Society in collaboration with scientists at the University of Arizona, Department of Nutritional Sciences and the University of Arizona Cancer Center.

SiDMAP scientists provided the metabolic analysis for the study using pancreatic cancer cells expressing K-ras differently, which is a common mutation in pancreatic cancer. They integrated positional 13C labeling in multiple metabolic products in diverse sampling sites from a single 13C labeled glucose tracer. It is known that stable expression of K-ras induces a pancreatic cancer metabolic phenotype that competes for new acetate, formed from glucose, in the cholesterol and fatty acid producing pathways. “Cholesterol administration diverts new acetate towards fatty acid synthesis, which provides the contextual factor for metformin to inhibit new fatty acid synthesis, cell membrane turnover and potentially cell growth,” said Dr. Laszlo G. Boros, Chief Scientist at SiDMAP.

“The study may explain the mechanism of how elevated circulating cholesterol, which is an important disease modifying factor in the diabetic pancreatic cancer patient, alters cellular metabolism in a way that metformin’s known fatty acid synthase inhibiting effect becomes a cell growth limiting factor,” said Dr. Emmanuelle J. Meuillet, the study’s lead investigator.

The work is published as a Springer Open Access a
'/>"/>

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Page: 1 2

Related medicine news :

1. New understanding of why anti-cancer therapy stops working at a specific stage
2. Anti-cancer drug viewed as possible Alzheimers treatment doesnt work in UF study
3. Overcoming resistance to anti-cancer drugs by targeting cell powerhouses
4. Progress after recent breakthrough which opened new chapter in anti-cancer cell therapies
5. Development of the first way to make large amounts of promising anti-cancer substance
6. First trial in humans of minicells: A completely new way of delivering anti-cancer drugs
7. Specialized MRI scans assess value of anti-cancer chemotherapy long before tumors shown to shrink
8. 1960s-era anti-cancer drug points to treatments for Lou Gehrigs disease
9. Moffitt Cancer Center researchers develop and test new anti-cancer vaccine
10. Patent Issued for Apparel and Textile Fabric with Antimicrobial Properties
11. New studies explore mangos potential health-affirming properties
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... Albany, New York (PRWEB) July 13, 2014 ... Share, Growth, Trends and Forecast 2013 - 2019 , ... the patients suffering from myopia or cataracts. The lenses ... crystalline. After the cataract surgery intraocular lens replaces the ... (PIOL) switches with original crystalline lens to deliver the ...
(Date:7/13/2014)... inexpensive, portable, microchip-based test for diagnosing type-1 diabetes ... better understand the disease, according to the device,s ... , Described in a paper to be published ... the test employs nanotechnology to detect type-1 diabetes ... the two main forms of diabetes mellitus, which ...
(Date:7/13/2014)... Recently, MillionaireCasket.com, a well-known casket manufacturer from China, ... Additionally, the company’s chief executive officer has announced a new ... are offered at discounted prices, from 15 to 26 percent ... are in huge demand in the current market. We are ... have a lot of high quality products for sale. Many ...
(Date:7/13/2014)... 13, 2014 The North American water storage ... 2013 to $5,450 million by 2018, at a CAGR of ... is expanding at a rapid pace in North America. The ... laws on water & wastewater storage and collection, and the ... market is expanding at a healthy rate in Canada, and ...
(Date:7/13/2014)... July 13, 2014 The report ... Molybdenum, Iron), Form (Chelated & Non Chelated), Application ... - Global Trends and Forecast to 2018” defines ... an analysis and forecasting of the global value ... the driving and restraining factors for the global ...
Breaking Medicine News(10 mins):Health News:Intraocular Lens (IOL) Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 2Health News:Intraocular Lens (IOL) Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 3Health News:Intraocular Lens (IOL) Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 4Health News:Stanford researchers invent nanotech microchip to diagnose type-1 diabetes 2Health News:Stanford researchers invent nanotech microchip to diagnose type-1 diabetes 3Health News:Stanford researchers invent nanotech microchip to diagnose type-1 diabetes 4Health News:Cheap Oak Caskets Recently Unveiled By China Casket Manufacturer MillionaireCasket.com 2Health News:North American Water Storage Systems Market is Expected to Reach $5,450 million by 2018 - New Report by MicroMarket Monitor 2Health News:North American Water Storage Systems Market is Expected to Reach $5,450 million by 2018 - New Report by MicroMarket Monitor 3Health News:Micronutrient Market Worth $6,474.6 Million by 2018 - A Report by MarketsandMarkets 2Health News:Micronutrient Market Worth $6,474.6 Million by 2018 - A Report by MarketsandMarkets 3Health News:Micronutrient Market Worth $6,474.6 Million by 2018 - A Report by MarketsandMarkets 4
... social growth might also see growing waistlines among their ... University and the University of Colorado. The ... improve conditions such as malnutrition and infectious disease, it ... "It,s a troubling finding," said Rice sociology ...
... from the NCAA will kick off a groundbreaking, long-term ... led by University of Michigan researchers and their colleagues ... to begin to fund a longitudinal study by the ... that includes three founding members from the University of ...
... Storrs HealthDay Reporter , TUESDAY, March 13 (HealthDay ... do with factors like race, age and where they live, ... to a new study. Researchers analyzed food questionnaires from ... and older in the continental United States, with a focus ...
... March 11 (HealthDay News) -- High school and college students around ... or sick on vacation can ruin the fun. The American ... take to prevent injuries and stay safe while traveling with their ... a person should go to the nearest ER so we can ...
... Madonna Behen HealthDay Reporter , THURSDAY, March 8 ... can take years off your life, but a new Israeli ... mid-80s, carrying some extra pounds might actually help you live ... that while obesity did increase the risk of dying for ...
... March 8, 2012 Research published today in the ... Ludwig Institute for Cancer Research (LICR) and Memorial Sloan-Kettering Cancer ... (ipilimumab), fostered a strong immune response and a favorable clinical ... of skin cancer. The size of both the tumor ...
Cached Medicine News:Health News:Economic and social growth of developing nations may increase obesity 2Health News:Groundbreaking, long-term study of head injuries among athletes kicks off with NCAA grant 2Health News:Groundbreaking, long-term study of head injuries among athletes kicks off with NCAA grant 3Health News:Race, Location Big Factors in American Diets 2Health News:Race, Location Big Factors in American Diets 3Health News:Spring Break Safety Tips to Keep Vacation Fun 2Health News:Could Fat Be Your Friend Over Age 85? 2Health News:Could Fat Be Your Friend Over Age 85? 3Health News:NEJM study shows combination treatments benefit melanoma patient 2
(Date:7/10/2014)... , July 10, 2014 Yesterday, ... Research,s (Moberg) medical device manufacturing facility. Rep. Kennedy ... advanced neurological monitors facilitate cutting-edge research in neurological ... Kennedy and mental health advocate, Garen Staglin ... dedicated to fostering fundamental changes that will radically ...
(Date:7/10/2014)... 2014   Ventana Medical Systems, Inc.  (Ventana), a ... entered into an agreement with Merck KGaA, Darmstadt, ... in the United States and ... KGaA,s biopharmaceutical division on the development and commercialization of ... Ventana,s proprietary diagnostic assays. In alignment with Merck KGaA,s ...
(Date:7/10/2014)... R.I. , July 10, 2014 CVS Caremark ... board of directors has approved a quarterly dividend of $0.275 ... dividend is payable on August 1, 2014, to holders of ... CVS Caremark is dedicated to helping people ... pharmacy company in the United States . ...
Breaking Medicine Technology:Representative Patrick Kennedy visits Moberg's medical device facility to discuss improvement in brain injury care 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 3
... Sept. 21 As consumer healthcare expenses rise, ... customer satisfaction has increased considerably from 2009, according ... National Pharmacy Study(SM) released today. ... http://www.newscom.com/cgi-bin/prnh/20050527/LAF028LOGO-a ) The study, now in ...
... 21 HealthWarehouse.com, Inc. (OTC Bulletin Board: ... Columbia Medical Associates, an outpatient clinic system offering medical ... partnership to offer patients a 30-day supply of more ... home delivery. Columbia Medical Associate,s "Columbia Care" ...
Cached Medicine Technology:J.D. Power and Associates Reports: As Consumers Shoulder More Healthcare Expenses, Cost Increasingly Drives Overall Customer Satisfaction With Pharmacies 2J.D. Power and Associates Reports: As Consumers Shoulder More Healthcare Expenses, Cost Increasingly Drives Overall Customer Satisfaction With Pharmacies 3J.D. Power and Associates Reports: As Consumers Shoulder More Healthcare Expenses, Cost Increasingly Drives Overall Customer Satisfaction With Pharmacies 4J.D. Power and Associates Reports: As Consumers Shoulder More Healthcare Expenses, Cost Increasingly Drives Overall Customer Satisfaction With Pharmacies 5HealthWarehouse.com Partners with Columbia Medical Associates to Bring Affordable Healthcare to Washington State 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: