Navigation Links
Metastasis formation revealed in detail and real time
Date:12/20/2009

ogy in nearby Martinsried, Winkler and his collaborators Yvonne Kienast and Louisa von Baumgarten have, for the first time, been able to follow the fate of single cancer cells, in real time, over periods long enough to allow the development of large metastases in the brain. The study used two-photon microscopy, which allows one to look deeper into tissues than is possible with conventional fluorescence microscopy. The technique can visualize, at high resolution, structures that lie hundreds of micrometers below the surface of the living brain. "Essentially, we were able to monitor the stages of metastasis formation live", remarks Yvonne Kienast.

Different fluorescent markers were used to label blood vessels (in green) and the tumor cells (in red) which the team injected directly. By extending their observations over many weeks, the researchers discovered that metastasis formation requires four steps. First, circulating tumor cells must get trapped at a fork in the network of blood vessels. "In contrast to previous reports, intravascular growth is not sufficient to induce a metastasis", reports Winkler. "We observed that such cells must then escape into the surrounding tissue by passing through tiny gaps between the cells of the vessel wall. In the third step, they have to stick to the outer surface of the vessel, where micrometastases, consisting of four to fifty cells, can develop.

It is the fourth step that gives the crucial signal for the development of a clinically relevant metastasis. This occurs when neighbouring micrometastases fuse and new blood vessels grow into the resulting mass. The latter process -- angiogenesis -- ensures that the tumor has a constant supply of nutrients, allowing it to grow unchecked. The imaging experiments also revealed the hurdles that cancer cells must overcome in order to form metastases. As Winkler points out, "Each one of the steps can go awry. Cells may not get out of the circulation, may fail to adhere to th
'/>"/>

Contact: Luise Dirscherl
dirscherl@lmu.de
49-089-218-02706
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Crosstalk between critical cell-signaling pathways holds clues to tumor invasion and metastasis
2. Potent metastasis inhibitor identified
3. M. D. Anderson launches graduate program in cancer metastasis
4. Metastasis-promoting protein identified; could provide a prognostic test or target for breast cancer
5. Lung cancer cells activate inflammation to induce metastasis
6. UNC researchers find clue to stopping breast-cancer metastasis
7. Jefferson researchers show antibody to breast cancer-secreted protein blocks metastasis
8. Smart bomb nanoparticle strategy impacts metastasis
9. Identification of 5 genes involved in the metastasis of breast tumors to the lung
10. A new weapon for attacking tumor invasion and metastasis
11. Jefferson, Ohio State team find gene signature profile for metastasis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... to a new market research report “Internet of Things ... Bluetooth, Wi-Fi, NFC, RFID), Application Vertical (Building Automation, Consumer, ... - Global Trends & Forecasts to 2014 - 2020”, ... $1029.5 Billion in 2013, and is expected to reach ... 4.08% from 2014 to 2020. , Browse more ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 As reported ... and FiercePharma (Weintraub 7/11/14), a significant number of severe ... sugar, abdominal issues and even death from the highly-promoted ... According to the Times report , a regulatory ... 2013 reported by patients was almost 14% of prescriptions, ...
(Date:7/11/2014)... NY (PRWEB) July 11, 2014 The ... the five years to 2014 on the heels of ... 2010 prompted farmers to dedicate a larger share of ... production. More specifically, the regulations required the mixing of ... expanding biofuel production in the United States created a ...
(Date:7/11/2014)... 2014 Ticket Down is a reliable source for ... View, CA. Over the years Luke Bryan has been honored ... does he do well at award shows, but each summer, he ... anticipated tours of the genre and this summer is more of ... compare to the popularity and success that is currently entitled to ...
(Date:7/11/2014)... July 11, 2014 Europe is one ... to large cultivated-and hence, irrigated land area. The agricultural ... Europe, accounting for around 30.0% of the total water ... greater in the southern region, but far from negligible ... irrigation accounts for over 60.0% of the water use ...
Breaking Medicine News(10 mins):Health News:Internet of Things Technology & Application Market Worth $1423.09 Billion by 2020 – New Report by MarketsandMarkets 2Health News:Internet of Things Technology & Application Market Worth $1423.09 Billion by 2020 – New Report by MarketsandMarkets 3Health News:Internet of Things Technology & Application Market Worth $1423.09 Billion by 2020 – New Report by MarketsandMarkets 4Health News:Acthar’s Deadly Adverse Events Revealed 2Health News:Acthar’s Deadly Adverse Events Revealed 3Health News:Corn Farming in Canada Industry Market Research Report Now Available From IBISWorld 2Health News:Corn Farming in Canada Industry Market Research Report Now Available From IBISWorld 3Health News:Luke Bryan Tickets Shoreline Amphitheatre in Mountain View, CA: Ticket Down Slashes Ticket Prices for Luke Bryan in Mountain View at the Shoreline Amphitheatre 2Health News:Luke Bryan Tickets Shoreline Amphitheatre in Mountain View, CA: Ticket Down Slashes Ticket Prices for Luke Bryan in Mountain View at the Shoreline Amphitheatre 3Health News:Europe Micro Irrigation System Market Driven by Growing Environmental Concerns and Decreasing Water Availability - New Report by MicroMarket Monitor 2Health News:Europe Micro Irrigation System Market Driven by Growing Environmental Concerns and Decreasing Water Availability - New Report by MicroMarket Monitor 3
... YWCA USA Annual General Assembly elected new officers and members of ... its recent 2009 National Conference in Washington, D.C.New officers include:, ... Debra Stock, Executive Director of YWCA York, Pennsylvania , ... Director of YWCA Greater Chicago, Illinois , ...
... Empire State Building,s lights to glow red in honor ... 14 , 12 Noon - 12:15 P.M. ... YORK, May 12 Gay Men,s Health Crisis (GMHC) ... the Empire State Building,s famed floodlights will soon honor ...
... A new study has sounded the alarm that ... lifespan and don,t exercise enough during their leisure time. ... and Physical Activity , the study is unique in ... 1981 Canada Fitness Survey, the 1988 Campbell,s Survey of ...
... coalition of health and human rights activists held simultaneous events in New ... release of two Iranian physicians imprisoned since June. , ... New York, ... and a coalition of health and human rights activists held simultaneous events ...
... Joseph,s Hospital and Medical Center, Phoenix, today announced the ... Inc. for the deployment of the company,s ... system will be used to connect specialist physicians at ... This program will include the Barrow Neurological Institute, as ...
... key in improving Alzheimer,s research , , TUESDAY, May 12 ... cerebrospinal fluid may help predict the rate of cognitive ... information could be used to improve the effectiveness of ... in the May issue of the journal Archives ...
Cached Medicine News:Health News:YWCA USA Elects New National Leadership 2Health News:Hilary Duff to Light Empire State Building Commemorating 24th Annual AIDS Walk New York 2Health News:Hilary Duff to Light Empire State Building Commemorating 24th Annual AIDS Walk New York 3Health News:22-year study finds adults aren't active enough 2Health News:Physicians for Human Rights and 20 Countries Demand Iran Release AIDS Doctors 2Health News:Physicians for Human Rights and 20 Countries Demand Iran Release AIDS Doctors 3Health News:St. Joseph's Hospital and Medical Center Signs Agreement for Innovative Video Conferencing Use 2Health News:Biomarkers May Help Measure Rate of Decline in Dementia 2
(Date:7/11/2014)... 11, 2014 Research and Markets ... Chinese Medical X-ray Film Industry Report 2014" report ... Global And Chinese Medical X-Ray Film ... on the current state of the Global medical X-ray ... The report provides a basic overview of the ...
(Date:7/11/2014)... , July 11, 2014  Kindred Hospital Houston ... announce the opening of its new outpatient wound ... services to people with chronic, hard to heal ... can lead to amputation, lower leg wounds related ... delayed closure, and traumatic injury wounds which are ...
(Date:7/11/2014)... York , July 11, 2014 ... Transparency Market Research "Endoscopy Devices Market (Endoscopes, Endoscopic Operative ... Share, Growth, Trends and Forecast, 2013-2019" the global endoscopy ... 2012 and is expected to grow at a CAGR ... estimated value of USD 36.9 billion in 2019. ...
Breaking Medicine Technology:Global and Chinese Medical X-ray Film Industry Report 2014 2Kindred Hospital Houston Northwest, With Wound Care Specialists, Opens Outpatient Wound Healing And Hyperbaric Center 2Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 2Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 3Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 4Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 5Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 6
... Dynatronics Corporation (NASDAQ: DYNT ) plans to ... March 31, 2012 during the morning of Tuesday, May 15, ... for investors later that day at 3:30 p.m. ET to ... Those interested in participating should call (800) 676-3536. ...
... Rogosin Institute (Rogosin) and the Hebrew Home at Riverdale ... and nephrology medical management for the residents and rehabilitation ... residents and patients of Hebrew Home will have peritoneal ... Hebrew Home are both members of NewYork Presbyterian Healthcare ...
Cached Medicine Technology:The Rogosin Institute and Hebrew Home Collaborate to Provide New Dialysis Service for Residents and Patients 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: