Navigation Links
Metastasis formation revealed in detail and real time
Date:12/20/2009

Up to 25% of cancer patients develop metastases in the brain often long after successful treatment of the primary tumor. In almost all such cases, the prognosis is poor. The mechanisms responsible for the appearance of brain metastases have long been mysterious. Now a research team led by neurologist Dr. Frank Winkler of LMU Munich has followed, in real time, the steps that lead some tumor cells to establish metastases, while others fail to form new tumors. The team also discovered that, by blocking formation of new blood vessels, the anti-cancer drug Avastin can suppress the emergence of metastases. "We hope that our results will help to optimize existing therapies and allow us to develop new agents that can be targeted against specific stages in the process of metastasis", says Winkler. (Nature Medicine online, 20. Dezember 2009)

It is not the primary tumor that kills most cancer patients, but the metastases which arise from it. Metastases in the brain are associated with a particularly dismal prognosis. These secondary tumors frequently appear in patients who have, or have had, lung, breast or skin cancers. They are very difficult to treat, as existing therapies can only slow, not cure, the disease. Brain metastases are also very distressing for patients, often causing headaches and nausea, but also serious neurological symptoms such as paralysis and loss of the ability to speak. "Unfortunately, brain metastases are now being seen more often than in the past", says Dr. Frank Winkler, who leads the Neurooncology Research Group at the LMU's Neurological Clinic in Munich. "Improvements in the treatment of malignancy have enhanced survival times. But this also means that more patients are at risk of developing brain metastases."

Exactly how metastases arise has been unclear. In close cooperation with Professor Jochen Herms of the LMU's Center for Neuropathology and Prion Research and scientists at the Max-Planck Institute for Neurobiol
'/>"/>

Contact: Luise Dirscherl
dirscherl@lmu.de
49-089-218-02706
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Crosstalk between critical cell-signaling pathways holds clues to tumor invasion and metastasis
2. Potent metastasis inhibitor identified
3. M. D. Anderson launches graduate program in cancer metastasis
4. Metastasis-promoting protein identified; could provide a prognostic test or target for breast cancer
5. Lung cancer cells activate inflammation to induce metastasis
6. UNC researchers find clue to stopping breast-cancer metastasis
7. Jefferson researchers show antibody to breast cancer-secreted protein blocks metastasis
8. Smart bomb nanoparticle strategy impacts metastasis
9. Identification of 5 genes involved in the metastasis of breast tumors to the lung
10. A new weapon for attacking tumor invasion and metastasis
11. Jefferson, Ohio State team find gene signature profile for metastasis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... 27, 2014 ALS Insights is a ... and comfort. It features a series of compelling interviews ... They share their insights, in searing honesty, about issues ... impact on children, what happened in the final days ... Challenge has created a dramatic increase in public awareness ...
(Date:8/27/2014)... Lake City, Utah (PRWEB) August 27, 2014 ... in advancing the business of healthcare, is pleased ... , a ground-breaking online recruitment resource specifically designed ... hiring is undergoing significant changes. To help address ... aging workforce, and tighter budgets—AAPC launched CareerHealth.com ...
(Date:8/27/2014)... CT (PRWEB) August 27, 2014 ... cyclists of all abilities to go the distance this ... Alex’s Million Mile – Run. Walk. Ride. initiative, hosted ... and increase awareness of childhood cancer. September represents ... year’s Alex’s Million Mile, Inspira Marketing Group has teamed ...
(Date:8/27/2014)... August 27, 2014 IntelliSoft Group, LLC, ... management software, will unveil IntelliCred, IntelliApp and ... of Medical Staff Services (NHAMSS) Annual Conference on September ... in Bedford, NH. , Notable improvements available in ... , Contract Linking: A new Contract Connection ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 A recently ... discusses the importance of time in correcting coagulopathy to ... on a variety of anticoagulants and examines medical conditions ... to the research, although anticoagulants have been approved by ... systemic embolism, they are also known to affect the ...
Breaking Medicine News(10 mins):Health News:ALS Insights Launched as Web Resource of Interviews and Information 2Health News:AAPC Responds to Healthcare Workforce Challenges with CareerHealth.com 2Health News:AAPC Responds to Healthcare Workforce Challenges with CareerHealth.com 3Health News:Alex’s Lemonade Stand Foundation Kicks Off Alex’s Million Mile – Run. Walk. Ride. with Labor Day 5k Run in New York City’s Hudson River Park 2Health News:Alex’s Lemonade Stand Foundation Kicks Off Alex’s Million Mile – Run. Walk. Ride. with Labor Day 5k Run in New York City’s Hudson River Park 3Health News:IntelliSoft Group to Unveil Version 14.2 of IntelliCred, IntelliApp and IntelliContract at the New Hampshire Association of Medical Staff Services Annual Conference 2Health News:Flood Law Group Comments on Recent AAICH Study 2
... treatment for recurrent Clostridium difficile infection (CDI), ... the official journal of the American Gastroenterological Association. Additionally, ... to be greater than in some previously reported series, ... rather safe procedure. CDI is a common cause of ...
... 14, 2012Research!America will honor some of our nation,s foremost ... Advocacy Awards tonight at the Andrew W. Mellon Auditorium ... leaders from government, industry, academia and health advocacy organizations ... have made an impact in advancing the nation,s commitment ...
... (HealthDay News) -- High school and college students around the country ... on vacation can ruin the fun. The American College of ... prevent injuries and stay safe while traveling with their friends or ... should go to the nearest ER so we can treat them," ...
... (HealthDay News) -- The drug misoprostol reduced major complications ... a new study. Doctors often use misoprostol for ... now, however, there were no studies large enough to ... complications, either immediate or delayed, according to background information ...
... , WEDNESDAY, March 7 (HealthDay News) -- Researchers report that ... system in patients who received kidney transplants, a process that ... organ instead of trying to reject it. There are ... number of patients. Also, the required procedure is expensive and ...
... Treatment with the common diabetes drug metformin appears ... infected with HIV. In a presentation today ... Infections, Massachusetts General Hospital (MGH) researchers reported that ... essentially no progression of coronary artery calcification during ...
Cached Medicine News:Health News:A new treatment option for Clostridium difficile: Fecal transplantation 2Health News:Research!America honors leading health research advocates 2Health News:Spring Break Safety Tips to Keep Vacation Fun 2Health News:Drug Reduces Complications in Surgical Abortions: Study 2Health News:Transplant Procedure Creates 'Hybrid' Immune System to Combat Rejection 2Health News:Transplant Procedure Creates 'Hybrid' Immune System to Combat Rejection 3Health News:Diabetes drug halts atherosclerosis progression in HIV-infected patients 2Health News:Diabetes drug halts atherosclerosis progression in HIV-infected patients 3
(Date:8/26/2014)... 2014  Actavis plc (NYSE: ACT ), a ... Saunders , CEO and President of Actavis, will provide an ... Stanley Global Healthcare Conference 2014 in New York, ... The presentation will take place on Tuesday, September ... Hyatt New York, 109 East 42 nd Street, ...
(Date:8/26/2014)... Research and Markets  has announced the ... 2014-2018" report to their offering. Intranasal ... the administration of drugs for the treatment of local ... allergic and non-allergic rhinitis and sinusitis. The nose is ... vaccination and systematic drug delivery. Continuous ...
(Date:8/26/2014)... comes to diabetes supplies, innovations are often accused of ... answer a real medical need. Fitting ... shows how long it,s been since your last injection. ... insulin doses. Very easy to use, Timesulin starts automatically ... after an injection. There is no settings or complicated ...
Breaking Medicine Technology:Actavis to Present at Morgan Stanley Global Healthcare Conference 2014 2Global Intranasal Drug Delivery Market 2014-2018: Key Vendors are Becton, Dickinson and Company, GlaxoSmithKline, Johnson & Johnson and Novartis 2Global Intranasal Drug Delivery Market 2014-2018: Key Vendors are Becton, Dickinson and Company, GlaxoSmithKline, Johnson & Johnson and Novartis 3Montméd obtains reimbursement of Timesulin, the smart insulin pen timer cap, by major insurance companies in Canada 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: