Navigation Links
Metals could forge new cancer drug
Date:10/18/2009

Drugs made using unusual metals could form an effective treatment against colon and ovarian cancer, including cancerous cells that have developed immunity to other drugs, according to research at the University of Warwick and the University of Leeds.

The study, published in the Journal of Medicinal Chemistry, showed that a range of compounds containing the two transition metals Ruthenium and Osmium, which are found in the same part of the periodic table as precious metals like platinum and gold, cause significant cell death in ovarian and colon cancer cells.

The compounds were also effective against ovarian cancer cells which are resistant to the drug Cisplatin, the most successful transition metal drug, which contains the metal platinum.

Dr Patrick McGowan, one of the lead authors of the research from the School of Chemistry at the University of Leeds, explains: "Ruthenium and Osmium compounds are showing very high levels of activity against ovarian cancer, which is a significant step forward in the field of medicinal chemistry.

Sabine H. van Rijt, lead researcher in the laboratory of Professor Peter Sadler in the Department of Chemistry at the University of Warwick, said:

"Most interestingly, cancerous cells that have shown resistance to the most successful transition metal drug, Cisplatin, show a high death rate with these new compounds."

Professor Sadler, at the University of Warwick, commented that he is "excited by the novel design features in these compounds which might enable activity to be switched on and off".

Cisplatin was discovered in the 1970s and is one of the most effective cancer drugs on the market, with a 95% cure rate against testicular cancer. Since the success of Cisplatin, chemists all over the world have been trying to discover whether other transition metal compounds can be used to treat cancer.

In this type of anti cancer drug transition metal atoms bind to DNA molecules which trigger apoptosis, or programmed cell death, in the cancerous cells.

The study is a collaboration between the universities of Warwick and Leeds and was funded by the Engineering and Physical Sciences Research Council (EPSRC).


'/>"/>

Contact: Peter Dunn
p.j.dunn@warwick.ac.uk
44-077-676-55860
University of Warwick
Source:Eurekalert  

Related medicine news :

1. Heavy Metals Can Taint Wine
2. New sensor system improves detection of lead, heavy metals
3. Biosensors to probe the metals menace
4. New laryngoscope could make difficult intubations easier
5. Findings about veracity of peripheral vision could lead to better robotic eyes
6. Social Security COLA: Tomorrows Zero COLA Announcement for 2010 Could Cost Average Senior $10,134
7. Quicker Referral for Gallbladder Operation Could Save 50 Percent of Preoperative Treatment Charges
8. Severe Swine Flu Could Lead to Blood Clots in Lungs: Study
9. A Gene Tweak Could Keep Heart Young
10. Increased levels of Muellerian-inhibiting substance could mean greater breast cancer risk
11. Cows Milk Protein Could Help Save Preemies Lives
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Metals could forge new cancer drug
(Date:12/7/2016)... , ... December 07, 2016 , ... ... consultation services from offices located in South Lyon, Dewitt, Williamston, East Lansing, Ann ... basketball coach who needs treatment for a brain tumor. , Jason Bauer and ...
(Date:12/7/2016)... , ... December 07, 2016 , ... ... and financial planning services to families and business owners in the greater Dallas ... behalf of the Dallas Fallen Officer Foundation. , Established in 2009 by active ...
(Date:12/7/2016)... (PRWEB) , ... December 07, 2016 , ... AlignLife clinics ... Many children are not fortunate enough to receive bountiful gifts wrapped tightly under ... presents can bring to the children of the world. , In exchange for generous ...
(Date:12/7/2016)... ... OCTOBER XX, 2016 (PRWEB) (PRWEB) December 07, 2016 , ... ... new study entitled “Canine Filamentous Dermatitis Associated with Borrelia Infection” ... The study was published in the prestigious Journal of Veterinary Science & Medical ...
(Date:12/7/2016)... ... December 07, 2016 , ... The Honolulu cosmetic and medical ... which launched October 17, 2016, features comprehensive information regarding a wide range of ... and patients can discover the latest clinical dermatology treatments for medical skin concerns ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... NORTH READING, Mass. , Dec. 7, 2016 ... Track and Trace Network for connecting the Life ... from the global marketplace, today announced that Tjoapack ... 50+ European pharmaceutical manufacturing customers comply with the ... Supply Chain Security Act (DSCSA) in 2017 and ...
(Date:12/7/2016)... 7, 2016  Varian Medical Systems (NYSE: ... announced plans to separate its Imaging Components business.  The ... distribution to Varian stockholders of common stock in Varex ... hold the Imaging Components business.  As part of the ... the end of January 2017, Varian will receive an ...
(Date:12/7/2016)... 7, 2016  Organovo Holdings, Inc. (NASDAQ: ... focused on delivering scientific and medical breakthroughs using ... and Chief Executive Officer Keith Murphy ... December 14, 2016 at 1:00 p.m. Eastern Time ... yet familiar with the Company, an informational video ...
Breaking Medicine Technology: