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Metal stents are effective treatment for blocked bile ducts
Date:3/20/2013

ign biliary strictures, but it's associated with significant complications and mortality. Today, minimally invasive endoscopic stent placement has emerged as a less invasive and more successful therapeutic option.

Only permanent plastic stents are currently FDA approved for benign stricture indications. However, these plastic stents involve multiple endoscopic procedures and multiple large stents. Also, plastic stents are often associated with stent blockages and failure of long-term durable results for stricture resolution.

FCSEMS are being tested in patients with benign biliary strictures to overcome the limitations of plastic stents, and the complications of their uncovered or semi-covered metal stent counterparts. The fully covered membrane design of FCSEMS prevents embedding and ingrowth of the stent into the bile duct's wall.

The research study examined 133 patient cases performed between April 2009 and October 2010 at six centers. Each patient received a FCSEMS during an endoscopic stenting procedure to open his or her severely narrowed or blocked benign bile duct stricture and restore bile flow. A 40, 60 or 80 millimeter length metal stent was implanted via a thin catheter to the blockage site over a guide wire. The stent was then partially deployed and pulled against the stricture prior to full deployment. These temporary metal stents were implanted all in one endoscopic procedure and removed after an average of three months.

This study is the first to analyze the safety and efficiency of these implanted metal stents for benign stricture resolution after their removal. "The study showed the majority of patients who received a metal stent had symptom relief, negative imaging for stricture and no need for repeat stent replacement except the patients who underwent liver transplant," says Dr. Kahaleh.

Stricture resolution after FCSEMS removal was 91.6 percent successful in post-surgical cases, 84.2 percent in gall
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Contact: Lauren Woods
Law2014@med.cornell.edu
646-317-7401
Weill Cornell Medical College
Source:Eurekalert

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