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Metabolically healthy women have same CVD risk regardless of BMI
Date:9/2/2013

Amsterdam, The Netherlands Monday 2 September 2013: Metabolically healthy women have the same cardiovascular disease risk regardless of their BMI, according to research presented at the ESC Congress today by Dr Sren Sktt Andersen and Dr Michelle Schmiegelow from Denmark. The findings in more than 260,000 subjects suggest that obese women have a window of opportunity to lose weight and avoid developing a metabolic disorder, which would increase their CVD risk.

Dr Schmiegelow said: "Obesity and/or metabolic disorders (hypertensive disorders [hypertension, gestational hypertension or pre-eclampsia], disorders in glucose-metabolism [diabetes, gestational diabetes] and elevated cholesterol levels [dyslipidemia]) are well known cardiovascular risk factors. Studies in middle aged men have found that obese and normal weight men have the same cardiovascular risk if they are metabolically healthy. Our study aimed to find out if the same was true for young fertile women."

The study used Danish national health databases and followed 261,489 women who had given birth during 2004-2009 with no prior history of cardiovascular disease. The women were divided into four categories according to their pre-pregnancy body mass index (BMI, kg/m2) and presence of metabolic disorders (present/not present) (see figure). The women's mean age was 31 years.

The women were followed for an average of 5 years following childbirth. Discharge diagnoses and data on cause of death were used to determine if the women had a heart attack, a stroke, or died. Metabolic disorders were defined using claimed prescription data related to hypertension, diabetes and dyslipidemia; thus, only disorders being treated were taken into account. The pregnancy-associated metabolic disorders were defined using diagnosis codes.

The researchers found that being overweight (BMI≥25 kg/m2) but metabolically healthy was not associated with an increased risk of a heart attack, str
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Contact: Jacqueline Partarrieu
press@escardio.org
44-754-070-4494
European Society of Cardiology
Source:Eurekalert

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