Navigation Links
Metabolic syndrome heightens risk for development of uric-acid kidney stones
Date:9/13/2007

DALLAS Sept. 13, 2007 Researchers at UT Southwestern Medical Center have found that patients suffering from the metabolic syndrome a cluster of conditions that increases the risk for heart disease, stroke and diabetes also have a propensity to develop highly acidic urine, which increases the risk of developing kidney stones.

The first study, to demonstrate this relationship independent of age and renal function, appears in the September issue of the Clinical Journal of the American Society of Nephrology.

The metabolic syndrome is characterized by a group of risk factors that include obesity, high blood pressure, diabetes and high cholesterol. The American Heart Association estimates that more than 50 million Americans suffer from the syndrome.

Our findings suggest that the presence of an increasing number of metabolic syndrome features augments the propensity for uric-acid stone formation, said Dr. Naim Maalouf, assistant professor of internal medicine and the studys lead author.

In previous studies, UT Southwestern researchers have found that people who were overweight or suffered from diabetes had highly acidic urine, which often leads to the development of uric-acid kidney stones.

The current findings indicate that people with the other components leading to the metabolic syndrome also have highly acidic urine.

The association of highly acidic urine with elevated levels of systolic blood pressure, serum glucose, triglycerides and lower levels of high-density lipoprotein cholesterol all features of the metabolic syndrome has not been previously reported, Dr. Maalouf said.

In the study, researchers recorded the height, weight and blood pressure of 148 participants who had never developed kidney stones. They also gathered blood and urine samples and tested the blood for features of the metabolic syndrome.

They found that participants with the metabolic syndrome had highly acidic urine, compared to participants without the syndrome, and the correlation was independent of factors already known to influence urine acidity such as age, gender and body weight.

This is the first time it has been shown that acidic urine, a major cause of uric-acid stone disease, is a part of the metabolic syndrome, said Dr. Khashayar Sakhaee, chief of mineral metabolism at UT Southwestern and senior author of the study. We also found that the relationship is not driven by body mass alone.

Uric-acid stones are more difficult to diagnose than other types of kidney stones because they dont show up on regular abdominal X-rays, often delaying the diagnosis and leading to the continued growth of a stone.


'/>"/>

Contact: Connie Piloto
connie.piloto@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Related medicine news :

1. Individuals With Metabolic Syndrome At Risk of Dying From Heart Disease
2. Weight Reduction Surgery Also Treats Metabolic Syndrome
3. Understanding The Link Between Metabolic Syndrome And Drinking Patterns
4. Metabolic problems related to clogged arteries
5. Teenage Obesity And Metabolic Syndrome
6. Obesity Hormone - Leptin may treat Metabolic Disorder
7. Japanese Face High Risk Of Heart Attack And Stroke, Metabolic Syndrome to Blame
8. Metabolic Syndrome More Likely To Cause Heart Failure
9. Clozapine Increases Risk Of Metabolic Syndrome
10. A Major Break Through in Treatment for Metabolic Syndrome
11. Metabolic Syndrome may Be Associated With Heart Function
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term ... long-term care insurance companies have a waiver for care if the client has a ... when the family pays for care, is often waived, so the benefits from their ...
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Yisrayl Hawkins, Pastor ... that explains one of the most popular and least understood books in the Holy ... and puzzling descriptions that have baffled scholars for centuries. Many have tossed it off ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, ... Development, has been awarded a contract by the Center for Medicare and Medicaid ... to accelerate the enterprise use of Agile methodologies in a consistent and high ...
(Date:10/13/2017)... ... , ... “America On The Brink”: the Christian history of the United States ... creation of published author, William Nowers. Captain Nowers and his wife, Millie, have ... thirty years in the Navy. Following his career as a naval aviator and ...
Breaking Medicine News(10 mins):
(Date:9/13/2017)... --  OrthoAtlanta has been named the official orthopedic and ... for the 2018 College Football Playoff (CFP) National Championship to ... in Atlanta, Georgia . OrthoAtlanta is proud ... participating in many activities leading up to, and including the ... ...
(Date:9/12/2017)... N.J. , Sept. 12, 2017  Consumer reviews on the ... Hearing as the number one company for hearing aids, ranking ... and fifteen other brands. ... Embrace Hearing Named #1 by Consumers For Hearing Aids ... Embrace Hearing is an online store that provides high ...
(Date:9/9/2017)... 2017 ... coming to Washington DC ... Tuesday, September 12 th – Monday, September 18 th .The Brain ... MRI brain scans to the public.Where:  BTF,s Mobile ... 501 K Street NW, Washington, D.C.What:BTF brings its nationwide initiative, the Road ...
Breaking Medicine Technology: