Navigation Links
Metabolic syndrome heightens risk for development of uric-acid kidney stones
Date:9/13/2007

DALLAS Sept. 13, 2007 Researchers at UT Southwestern Medical Center have found that patients suffering from the metabolic syndrome a cluster of conditions that increases the risk for heart disease, stroke and diabetes also have a propensity to develop highly acidic urine, which increases the risk of developing kidney stones.

The first study, to demonstrate this relationship independent of age and renal function, appears in the September issue of the Clinical Journal of the American Society of Nephrology.

The metabolic syndrome is characterized by a group of risk factors that include obesity, high blood pressure, diabetes and high cholesterol. The American Heart Association estimates that more than 50 million Americans suffer from the syndrome.

Our findings suggest that the presence of an increasing number of metabolic syndrome features augments the propensity for uric-acid stone formation, said Dr. Naim Maalouf, assistant professor of internal medicine and the studys lead author.

In previous studies, UT Southwestern researchers have found that people who were overweight or suffered from diabetes had highly acidic urine, which often leads to the development of uric-acid kidney stones.

The current findings indicate that people with the other components leading to the metabolic syndrome also have highly acidic urine.

The association of highly acidic urine with elevated levels of systolic blood pressure, serum glucose, triglycerides and lower levels of high-density lipoprotein cholesterol all features of the metabolic syndrome has not been previously reported, Dr. Maalouf said.

In the study, researchers recorded the height, weight and blood pressure of 148 participants who had never developed kidney stones. They also gathered blood and urine samples and tested the blood for features of the metabolic syndrome.

They found that participants with the metabolic syndrome had highly acidic urine, compared to participants without the syndrome, and the correlation was independent of factors already known to influence urine acidity such as age, gender and body weight.

This is the first time it has been shown that acidic urine, a major cause of uric-acid stone disease, is a part of the metabolic syndrome, said Dr. Khashayar Sakhaee, chief of mineral metabolism at UT Southwestern and senior author of the study. We also found that the relationship is not driven by body mass alone.

Uric-acid stones are more difficult to diagnose than other types of kidney stones because they dont show up on regular abdominal X-rays, often delaying the diagnosis and leading to the continued growth of a stone.


'/>"/>

Contact: Connie Piloto
connie.piloto@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Related medicine news :

1. Individuals With Metabolic Syndrome At Risk of Dying From Heart Disease
2. Weight Reduction Surgery Also Treats Metabolic Syndrome
3. Understanding The Link Between Metabolic Syndrome And Drinking Patterns
4. Metabolic problems related to clogged arteries
5. Teenage Obesity And Metabolic Syndrome
6. Obesity Hormone - Leptin may treat Metabolic Disorder
7. Japanese Face High Risk Of Heart Attack And Stroke, Metabolic Syndrome to Blame
8. Metabolic Syndrome More Likely To Cause Heart Failure
9. Clozapine Increases Risk Of Metabolic Syndrome
10. A Major Break Through in Treatment for Metabolic Syndrome
11. Metabolic Syndrome may Be Associated With Heart Function
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... IN (PRWEB) , ... March 29, 2017 , ... ... Study, this webinar provides insight into the challenges employers face in trying to ... complexity of managing employee benefits programs? Adding to the growing complexity, companies ...
(Date:3/29/2017)... WI (PRWEB) , ... March 29, 2017 , ... Dr. ... on early orthodontic treatment and accepting new pediatric patients, with or without a referral. ... young patients have a better orthodontic outcome and experience. When patients receive early treatment, ...
(Date:3/29/2017)... MINNETONKA, Minn. (PRWEB) , ... March 29, 2017 ... ... of medical office buildings (MOBs) and other outpatient facilities, and who are the ... look exclusively at those questions, Revista and Healthcare Real Estate Insights (HREI) found ...
(Date:3/29/2017)... ... March 29, 2017 , ... Curio Wellness , ... announce the finalization of the company’s executive management team with prominent executives from both ... is Curio Wellness’ Chief Operating Officer, Ted Dumbauld , who has more than ...
(Date:3/29/2017)... ... March 29, 2017 , ... HealthCareMandA.com will host an important webinar — ... 1:00 PM ET. A recording of the webinar will also be made available following ... health and hospice companies are still popular targets for healthcare investors. This highly fragmented ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... , March 29, 2017  BioSpecifics Technologies Corp. ... continues to develop collagenase based-therapies with a first ... marketed as XIAFLEX ®  in the U.S. and ... present a corporate overview at the upcoming 16 ... April 5, 2017 at 8:00 a.m. ET in ...
(Date:3/29/2017)... , Mar. 29, 2017 Research and Markets ... Treated at Proton Therapy Centers & Forecast" report to their offering. ... Proton Therapy Market in ... from its market value in 2016. There are currently three proton therapy ... capacity to treat more patients. In Italy , the ...
(Date:3/29/2017)... , Mar. 29, 2017 Research ... Navigation Systems Market 2014 - 2025" report to their ... ... reach USD 303.7 million by 2025. Increasing geriatric population prone ... demand for orthopedic navigation systems over the forecast period. Osteoarthritis ...
Breaking Medicine Technology: