Navigation Links
Metabolic syndrome heightens risk for development of uric-acid kidney stones
Date:9/13/2007

DALLAS Sept. 13, 2007 Researchers at UT Southwestern Medical Center have found that patients suffering from the metabolic syndrome a cluster of conditions that increases the risk for heart disease, stroke and diabetes also have a propensity to develop highly acidic urine, which increases the risk of developing kidney stones.

The first study, to demonstrate this relationship independent of age and renal function, appears in the September issue of the Clinical Journal of the American Society of Nephrology.

The metabolic syndrome is characterized by a group of risk factors that include obesity, high blood pressure, diabetes and high cholesterol. The American Heart Association estimates that more than 50 million Americans suffer from the syndrome.

Our findings suggest that the presence of an increasing number of metabolic syndrome features augments the propensity for uric-acid stone formation, said Dr. Naim Maalouf, assistant professor of internal medicine and the studys lead author.

In previous studies, UT Southwestern researchers have found that people who were overweight or suffered from diabetes had highly acidic urine, which often leads to the development of uric-acid kidney stones.

The current findings indicate that people with the other components leading to the metabolic syndrome also have highly acidic urine.

The association of highly acidic urine with elevated levels of systolic blood pressure, serum glucose, triglycerides and lower levels of high-density lipoprotein cholesterol all features of the metabolic syndrome has not been previously reported, Dr. Maalouf said.

In the study, researchers recorded the height, weight and blood pressure of 148 participants who had never developed kidney stones. They also gathered blood and urine samples and tested the blood for features of the metabolic syndrome.

They found that participants with the metabolic syndrome had highly acidic urine, compared to participants without the syndrome, and the correlation was independent of factors already known to influence urine acidity such as age, gender and body weight.

This is the first time it has been shown that acidic urine, a major cause of uric-acid stone disease, is a part of the metabolic syndrome, said Dr. Khashayar Sakhaee, chief of mineral metabolism at UT Southwestern and senior author of the study. We also found that the relationship is not driven by body mass alone.

Uric-acid stones are more difficult to diagnose than other types of kidney stones because they dont show up on regular abdominal X-rays, often delaying the diagnosis and leading to the continued growth of a stone.


'/>"/>

Contact: Connie Piloto
connie.piloto@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Related medicine news :

1. Individuals With Metabolic Syndrome At Risk of Dying From Heart Disease
2. Weight Reduction Surgery Also Treats Metabolic Syndrome
3. Understanding The Link Between Metabolic Syndrome And Drinking Patterns
4. Metabolic problems related to clogged arteries
5. Teenage Obesity And Metabolic Syndrome
6. Obesity Hormone - Leptin may treat Metabolic Disorder
7. Japanese Face High Risk Of Heart Attack And Stroke, Metabolic Syndrome to Blame
8. Metabolic Syndrome More Likely To Cause Heart Failure
9. Clozapine Increases Risk Of Metabolic Syndrome
10. A Major Break Through in Treatment for Metabolic Syndrome
11. Metabolic Syndrome may Be Associated With Heart Function
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2017)... ... May 23, 2017 , ... Therachat , a smart ... in an infographic on the current state of anxiety in support of National Mental ... was conducted in April 2017 and benchmarked general anxiety levels as well as identified ...
(Date:5/22/2017)... NC (PRWEB) , ... May 22, 2017 , ... ... Matthews Periodontics, is now welcoming new patients with periodontal plastic surgery treatments, including ... from a general dentist. Dr. Green provides these esthetic and functional procedures to ...
(Date:5/22/2017)... ... May 22, 2017 , ... Galena, Alaska, has a population of less ... headlines when it was targeted to build a nuclear plant by the TOSHIBA Corporation. ... manager Marvin L. Yoder describes the journey to get power to his small town, ...
(Date:5/21/2017)... (PRWEB) , ... May 19, 2017 , ... Chris Cornell, 52, was found dead on ... why one of the most respected lead singers in the rock industry would take his ... of mental illness. FindaTopDoc investigates how mental illness played a role in the death of ...
(Date:5/21/2017)... PARK, FL (PRWEB) , ... May 20, 2017 , ... ... sell it, find it, review it, and share its attributes like never before. More ... dispensary directory to connect cannabis enthusiasts to stores, strains, products – and for the ...
Breaking Medicine News(10 mins):
(Date:5/8/2017)...  Diplomat Pharmacy, Inc. (NYSE: DPLO)., has completed its ... health care service center company based in ... relationship management programs for leading pharmaceutical manufacturers and health ... WRB will join Envoy Health Management, LLC , ... biotech firms, and other service companies. Together, WRB and ...
(Date:5/4/2017)... May 4, 2017  A recent study published ... Ultraviolet-C light as a means of disinfection ... to reduce bioburden on anesthesia workstations. In the ... high-touch, complex medical equipment surfaces contaminated with three ... "This study further validates the body of ...
(Date:5/4/2017)... 2017   BioLife Solutions , Inc. (NASDAQ: ... of proprietary clinical grade hypothermic storage and ... today announced that the Company,s first quarter 2017 financial ... May 11, 2017, and that the Company will host ... PT that afternoon. Management will provide an overview of ...
Breaking Medicine Technology: