Navigation Links
Metabolic syndrome biomarkers predict lung function impairment after exposure to WTC dust
Date:11/17/2011

Metabolic syndrome biomarkers predict subsequent decline in lung function after particulate exposure, according to new research involving rescue personnel exposed to World Trade Center (WTC) dust.

In a nested case-control study of 327 non-smoking FDNY 9/11 rescue workers, metabolic syndrome biomarkers measured within six months of exposure to WTC dust predicted decline of forced expiratory volume in one second (FEV1) over the next six years.

"Study participants with dyslipidemia, elevated heart rate or elevated leptin levels had a significantly increased risk of developing abnormal lung function during follow-up," said Anna Nolan, MD, MS, assistant professor of Medicine and Environmental Medicine at NYU Langone Medical Center. "In contrast, elevated amylin levels reduced the risk of developing abnormal FEV1 levels."

The findings were published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

This case-control study was nested within a larger longitudinally followed cohort. All subjects had normal lung function prior to 9/11. Cases (n = 109) were defined as having FEV1 values below the lower limit of normal at follow-up, while controls (n = 218) were defined as having FEV1 at or above the lower limit of normal. Biomarkers were available for 71 cases and 166 controls. Lung function in cases continually declined in the median 28 months between baseline and follow-up examinations, while lung function improved in controls.

In a model adjusting for age, race, body mass index and WTC arrival time, dyslipidemia (triglycerides≥150mg/dL and HDL<40mg/dL) increased the odds of being a case three-fold, elevated heart rate (≥66 bpm) increased the odds more than two-fold, and elevated leptin (≥10,300 pg/mL) increased the odds three-fold. Elevated amylin levels (≥116 pg/mL) decreased the odds of being a case by 84 percent. "This is the first report in humans showing an association between amylin and lung function," Dr. Nolan said. "There are amylin receptors in the lungs, and amylin has been shown to reduce leptin resistance. The protection offered by amylin in this study may have been mediated by these effects."

"These findings suggest that systemic inflammation, a hallmark of the metabolic syndrome, may play a role in promoting lung function impairment in patients with particulate exposure," Dr. Nolan said. "Given the high prevalence of the metabolic syndrome in industrialized nations and the rising incidence in developing nations with high ambient particulate levels, the relationship between these disorders is of considerable importance."

The study had a few limitations. Use of a single cohort of rescue workers limits extrapolation of these results to other cohorts. There was no unexposed control group in this study, so replication of these findings in populations with and without exposure to particulate matter is needed. Finally, other possible causes of lung dysfunction were not explored.

"Our findings in WTC rescue workers highlight the importance of conducting rapid medical monitoring and sample banking following a disaster," said Dr. Nolan. "If we can identify individuals at greater risk of developing lung function impairment, we can initiate appropriate interventions earlier."


'/>"/>

Contact: Nathaniel Dunford
ndunford@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Mild-mannered metabolic helper rushes to fight invading viruses, researchers report
2. Flies offer insight into human metabolic disease
3. Vitamin D Deficiency Linked to Diabetes, Metabolic Syndrome in Studies
4. Metabolic syndrome in living kidney donors worsens function of remaining kidney
5. Low vitamin D linked to the metabolic syndrome in elderly people
6. LSUHSC study finds early predictors of metabolic syndrome in healthy 7-9 year-olds
7. UC San Diego researchers find cause of metabolic disease -- and possible cure
8. Metabolic status before pregnancy predicts subsequent gestational diabetes
9. Moderate alcohol consumption lowers the risk of metabolic diseases
10. Loud snoring and insomnia symptoms predict the development of the metabolic syndrome
11. Vitamins C and E linked to metabolic syndrome in low-income Ecuadorians
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... ... 11, 2016 , ... Life is known for throwing curves. It’s thrown quite ... gather once a year to play softball to raise money through Sun Health ... than 50 players who competed in this year’s softball tournament share a history of ...
(Date:2/11/2016)... ... February 11, 2016 , ... ... their ongoing community involvement program, introduces a new charity campaign to raise funds ... are now being accepted at https://donate.rmhc.org/ . , Ronald McDonald House (RMH) ...
(Date:2/11/2016)... ... 2016 , ... From March 4 through 6, Hidrex ... at the Walter E. Washington Convention Center in Washington, D.C. , At the ... hyperhidrosis (excessive sweating) and its treatment options. Specifically, the company will be talking ...
(Date:2/11/2016)... Ore. (PRWEB) , ... February 11, 2016 , ... ... Medicaid coverage results in significantly higher rates of several common cancer screenings, especially ... resulting in better outcomes and survival rates. , The study,“What Does Medicaid ...
(Date:2/10/2016)... ... ... Early this week, Team Iconic at J. Walter Thompson and Nestlé KITKAT ... global confectionery brand sourced from 100% sustainable cocoa. , The Nestlé Cocoa Plan aims ... activities that focus on better farming, better lives and better cocoa. In order to ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... Genomic Health, Inc. (Nasdaq: GHDX ) today reported financial ... 31, 2015. --> --> Revenue ... $69.1 million in the fourth quarter of 2014, an increase of ... compared with the same period in the prior year. ... in the fourth quarter of 2015, an increase of 9 percent ...
(Date:2/10/2016)... HERTFORDSHIRE, England och ... -- Erbjudandet lämnas inte, och detta ... eller indirekt, i eller till, och inga ... uppdrag av aktieägare i, något land där ... av accept av Erbjudandet skulle strida mot ...
(Date:2/10/2016)... Mylan N.V. (NASDAQ, TASE: MYL) today announced ... December 31, 2015. --> --> ... revenues of $9.45 billion, up 28% on a constant ... of $9.43 billion. Excluding the impact of the acquisition ... generics business (the "EPD Business"), full year adjusted total ...
Breaking Medicine Technology: