Navigation Links
Metabolic protein wields phosphate group to activate cancer-promoting genes
Date:8/16/2012

HOUSTON - A metabolic protein that nourishes cancer cells also activates tumor-promoting genes by loosening part of the packaging that entwines DNA to make up chromosomes, a team led by scientists at The University of Texas MD Anderson Cancer Center reports in the Aug. 16 issue of Cell.

Working in cell lines and mouse models of glioblastoma multiforme, the most lethal form of brain tumor, senior author Zhimin Lu, Ph.D., associate professor of Neuro-Oncology at MD Anderson, and colleagues show that pyruvate kinase M2 (PKM2) fuels tumor growth by influencing a histone protein.

DNA is packaged in and spooled around histone proteins. The researchers found that PKM2 tags histone H3 with a phosphate group (one atom of phosphorous, four of oxygen) in a specific location called T11.

'No phosphorylation of H3, no tumor'

This phosphorylation leads to activation of the tumor-promoting genes, increased tumor cell reproduction and formation of tumors, Lu said. "If there's no phosphorylation of H3, there's no tumor. It's that crucial to glioblastoma formation."

An analysis of 85 human glioblastomas indicated that higher levels of PKM2 expression in the cell nucleus and of H3 phosphorylation are correlated with shorter survival. A separate analysis showed higher levels of H3 phosphorylation associated with higher grade tumors in a comparison of 30 low-grade tumor samples and 45 high grade glioblastomas.

"Histone 3-T11 phosphorylation has great potential to serve as both a prognostic marker and a guide for the use of PKM2-inhibiting therapies once they are developed," Lu said.

PKM2 has long been known for its well-established role in aerobic glycolysis - the processing of glucose into energy that solid tumors, glioblastomas in particular, rely on heavily to survive and grow. Lu and colleagues have been teasing out the mechanisms of PKM2's other role - the transcription and activation of genes.
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Normal triglyceride levels in people of African descent may hinder diagnosis of metabolic syndrome
2. Study: Women not getting enough exercise; at risk of developing metabolic syndrome
3. Mutant Kras drives pancreatic cancer maintenance via metabolic pathways
4. VCU researchers identify changes in cholesterol metabolic pathways
5. Metabolic Cooking Review For Karine Losier and Dave Ruel's Diet And Cookbook Program Released
6. Bees shed light on human sweet perception and metabolic disorders
7. Warwick scientists uncover how checkpoint proteins bind chromosomes
8. Specific protein triggers changes in neurons in brain reward center linked to cocaine addiction
9. Unusual protein helps regulate key cell communication pathway
10. Protein prevents DNA damage in the developing brain and might serve as a tumor suppressor
11. RANK protein promotes the initiation, progression and metastasis of human breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Metabolic protein wields phosphate group to activate cancer-promoting genes
(Date:10/22/2014)... (PRWEB) October 22, 2014 Shriners Hospitals ... that will change the current location of Shriners Hospitals ... South Limestone across from the University of Kentucky Albert ... state-of-the-art ambulatory care center, owned and operated by Shriners ... orthopaedic needs of children and their families well into ...
(Date:10/22/2014)... Angeles, California (PRWEB) October 22, 2014 Hay ... 2.0: Move Beyond Addiction and Upgrade Your Life (Paperback; $10.82) ... field of Yoga & Recovery. This book is meant ... thrive in a life of recovery. , Recovery 2.0 ... the 12 Steps; Recovery 2.0 is a guide for what ...
(Date:10/22/2014)... Pass, OR (PRWEB) October 22, 2014 ... Southern California’s fresh water supply runs dangerously low, Southern ... change. Southern Oregon’s rivers, despite the lowest mountain snow ... even in late summer and early autumn.* That was ... authors of the new book “Hiking Southern Oregon,” during ...
(Date:10/22/2014)... Texas (PRWEB) October 22, 2014 ... of completing their continuing education at home or ... have access to 20 brand new, premium Seminar-on-Demand ... robust catalog of over 2,000 hours ... fully customize their educational experience. With such a ...
(Date:10/22/2014)... Although there are only 24 hours in a day, ... have trouble finding time within their busy schedules for exercise and ... of time to get in shape. Here are five ways you ... , Change Up Your Commute , Consider riding a bike ... exercise into your daily routine. If you must use your car ...
Breaking Medicine News(10 mins):Health News:Shriners Hospitals for Children - Lexington Announces Plan to Build New $47 Million Facility 2Health News:Shriners Hospitals for Children - Lexington Announces Plan to Build New $47 Million Facility 3Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 2Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 3Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 2Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 3Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 4Health News:Top Provider of Continuing Education at Home Releases 20 New Online Courses 2Health News:HealthGuideMD Presents Ways to Improve Your Exercise and Fitness 2
... study on sleep patterns in American women found that most of ... and physical health// , personal lives, professional work and driving safety. ... Foundation, studied about 1,003 adult women in ages 18 t0 65 ... get less than one or two nights of good sleep each ...
... Smailholm and the border areas has raised the concern ... village hall where drumming classes were being conducted. ... Sabre, to look into this matter. The finding revealed ... areas in Northumberland and the Borders, including Smailholm Village ...
... consulate in Hyderabad will start operations in a makeshift location ... permanent// facility in five years time. ,The US ... April so that work could begin to set up the ... by Henrietta H. Fore, under secretary of state for management, ...
... says a study that adds to a weight of evidence ... the peppers their zing. ,According to the latest ... National Chung Hsing University in Taiwan, capsaicin makes fat cells ... ,The result of the study is reported in the Journal ...
... from the renowned Salk Institute for Biological Studies, have discovered ... secretion will not only reduce insulin resistance, in animal models, ... high calorie diet. , The peptide in question ... are peptides produced in the insulin secreting cells ...
... 2007 -- A team of UCSB researchers, in collaboration ... of Los Gatos, California, has designed a novel ... the skin without the pain or bruising that deeper ... today in the Proceedings of the National Academy of ...
Cached Medicine News:Health News:Sleep Problems of Women 2Health News:US Consulate to Start Hyderabad Operations Next Year 2Health News:Scientists Explore Ways to Reduce Insulin Resistance by ‘handcuffing’ Gen 2Health News:Researchers Design Pulsed Mircrojet System to Deliver Protein Drugs Without Pain or Bruising 2
(Date:10/20/2014)... Calif. , Oct. 20, 2014  PneumRx, Inc. ... interventional pulmonology, today announced completion of enrollment in their ... RENEW Clinical Study is the FDA-approved IDE pivotal trial ... severe emphysema. It was anticipated that the ... February 2013, would take until the end of 2014 ...
(Date:10/20/2014)... BOSTON , Oct. 20, 2014  Indianapolis ... and Toronto -based 3D visualization ... the Congress of Neurological Surgeons Annual Meeting that ... technologies for brain surgery. The collaboration is the ... powerful combination to improve patient outcomes. NICO,s BrainPath® ...
(Date:10/20/2014)... 2014  ResMed (NYSE: RMD ) ... Exchange program, a comprehensive suite of software and ... other health care providers. ResMed ... patient information. It integrates valuable sleep and respiratory ... management platforms with customers, in-house or third-party electronic ...
Breaking Medicine Technology:PneumRx Completes RENEW Pivotal Trial Enrollment 2PneumRx Completes RENEW Pivotal Trial Enrollment 3Indianapolis' NICO Corporation and Toronto's Synaptive Medical, Inc. Announce First-Ever Intervention-Visualization Partnership with Goal to Improve Standard of Care in Neurosurgery 2Indianapolis' NICO Corporation and Toronto's Synaptive Medical, Inc. Announce First-Ever Intervention-Visualization Partnership with Goal to Improve Standard of Care in Neurosurgery 3Indianapolis' NICO Corporation and Toronto's Synaptive Medical, Inc. Announce First-Ever Intervention-Visualization Partnership with Goal to Improve Standard of Care in Neurosurgery 4Indianapolis' NICO Corporation and Toronto's Synaptive Medical, Inc. Announce First-Ever Intervention-Visualization Partnership with Goal to Improve Standard of Care in Neurosurgery 5ResMed Launches ResMed Data Exchange 2
... ST. PAUL, Minn., Oct. 28 M.B.A. students ... and CEO Eric Elliott speak about the history ... Therapeutics is a pharmacy benefit management company dedicated ... clients and members. In a speech ...
... 28, 2010 The enVision e ICU® Center ... Virginia Hospital Alliance (NVHA) Regional Hospital Coordinating Center to ... surge capabilities in the region.  Inova,s enVision e ... using eICU Program technology from Philips VISICU. ...
Cached Medicine Technology:Columbia University Students Learn About Pharmacy Benefit Management From Prime Therapeutics President and CEO 2NVHA and Inova Health System Utilize Philips VISICU eICU® Program to Increase Surge Capacity During All-Hazards Event 2NVHA and Inova Health System Utilize Philips VISICU eICU® Program to Increase Surge Capacity During All-Hazards Event 3
Autolensmeter with black/white monitor and no internal printer....
FF 450plus IR Fundus camera with Visupac / System 451. High-end system for visualizing even the finest detail and reliable diagnosis....
... CL-100 measures all types ... with improved precision. The ... senses multi-focal lenses with ... makes operation easier while ...
... is designed for fast and easy operation ... mode, the readings are automatically held when ... are automatically detected. The sophisticated alignment system ... The TL-2000A has been designed with a ...
Medicine Products: