Navigation Links
Metabolic protein wields phosphate group to activate cancer-promoting genes
Date:8/16/2012

HOUSTON - A metabolic protein that nourishes cancer cells also activates tumor-promoting genes by loosening part of the packaging that entwines DNA to make up chromosomes, a team led by scientists at The University of Texas MD Anderson Cancer Center reports in the Aug. 16 issue of Cell.

Working in cell lines and mouse models of glioblastoma multiforme, the most lethal form of brain tumor, senior author Zhimin Lu, Ph.D., associate professor of Neuro-Oncology at MD Anderson, and colleagues show that pyruvate kinase M2 (PKM2) fuels tumor growth by influencing a histone protein.

DNA is packaged in and spooled around histone proteins. The researchers found that PKM2 tags histone H3 with a phosphate group (one atom of phosphorous, four of oxygen) in a specific location called T11.

'No phosphorylation of H3, no tumor'

This phosphorylation leads to activation of the tumor-promoting genes, increased tumor cell reproduction and formation of tumors, Lu said. "If there's no phosphorylation of H3, there's no tumor. It's that crucial to glioblastoma formation."

An analysis of 85 human glioblastomas indicated that higher levels of PKM2 expression in the cell nucleus and of H3 phosphorylation are correlated with shorter survival. A separate analysis showed higher levels of H3 phosphorylation associated with higher grade tumors in a comparison of 30 low-grade tumor samples and 45 high grade glioblastomas.

"Histone 3-T11 phosphorylation has great potential to serve as both a prognostic marker and a guide for the use of PKM2-inhibiting therapies once they are developed," Lu said.

PKM2 has long been known for its well-established role in aerobic glycolysis - the processing of glucose into energy that solid tumors, glioblastomas in particular, rely on heavily to survive and grow. Lu and colleagues have been teasing out the mechanisms of PKM2's other role - the transcription and activation of genes.
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Normal triglyceride levels in people of African descent may hinder diagnosis of metabolic syndrome
2. Study: Women not getting enough exercise; at risk of developing metabolic syndrome
3. Mutant Kras drives pancreatic cancer maintenance via metabolic pathways
4. VCU researchers identify changes in cholesterol metabolic pathways
5. Metabolic Cooking Review For Karine Losier and Dave Ruel's Diet And Cookbook Program Released
6. Bees shed light on human sweet perception and metabolic disorders
7. Warwick scientists uncover how checkpoint proteins bind chromosomes
8. Specific protein triggers changes in neurons in brain reward center linked to cocaine addiction
9. Unusual protein helps regulate key cell communication pathway
10. Protein prevents DNA damage in the developing brain and might serve as a tumor suppressor
11. RANK protein promotes the initiation, progression and metastasis of human breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Metabolic protein wields phosphate group to activate cancer-promoting genes
(Date:7/14/2014)... According to a new market research report ... and Others), Devices (Power IC, Power Module & Power ... 2014 - 2020", the Power Electronics market is expected ... market is valued at $36.86 Billion and expected to ... The report also includes an in-depth analysis of the ...
(Date:7/14/2014)... SingaporeA*STAR,s Bioprocessing Technology Institute (BTI) has entered into ... pharmaceutical company, Roche, to identify novel drug candidates ... partnership brings together BTI,s capabilities in novel antibody ... (mAbs) therapeutics, opening up the possibility of ... death worldwide. , The collaboration makes use ...
(Date:7/14/2014)... Botanica Day Spa announced last month that ... at the day spa in down town Clearwater, FL ... other refreshments will be served as clients are invited ... products and great deals on spa services, including ... Dermaplaning (also known as “facial shaving”) is a simple ...
(Date:7/14/2014)... HealthDay Reporter SUNDAY, July ... a faltering sense of smell might signal the early ... smell test could spot who needs more extensive screening ... ability to identify odors was associated with the loss ... "We,re trying to be able to diagnose Alzheimer,s ...
(Date:7/14/2014)... Amy Norton HealthDay ... Older adults who enjoy mentally stimulating games may have bigger ... suggests. The study looked at the connection between playing ... acuity for adults in their 50s and 60s. Researchers ... other day performed better on tests of memory and other ...
Breaking Medicine News(10 mins):Health News:Power Electronics Market Estimated to Reach $36.86 Billion by 2020 at CAGR of 7.74% - New Report by MarketsandMarkets 2Health News:Power Electronics Market Estimated to Reach $36.86 Billion by 2020 at CAGR of 7.74% - New Report by MarketsandMarkets 3Health News:Power Electronics Market Estimated to Reach $36.86 Billion by 2020 at CAGR of 7.74% - New Report by MarketsandMarkets 4Health News:Power Electronics Market Estimated to Reach $36.86 Billion by 2020 at CAGR of 7.74% - New Report by MarketsandMarkets 5Health News:A*STAR partners Roche to develop new cancer therapeutics 2Health News:Botanica Day Spa to Feature Dermaplaning at Upcoming Open House 2Health News:Botanica Day Spa to Feature Dermaplaning at Upcoming Open House 3Health News:Could a Simple Smell Test Help Spot Alzheimer's Early? 2Health News:Could a Simple Smell Test Help Spot Alzheimer's Early? 3Health News:Can Games, Puzzles Keep Aging Minds Sharp? 2Health News:Can Games, Puzzles Keep Aging Minds Sharp? 3
... a newborn baby going under the knife to repair a ... work begins for parents. University of Alberta nursing professor Gwen ... a former pediatric cardiology nurse; she wanted to find out ... per cent convinced that health-care professionals get what these parents ...
... 26 The Providence Service,Corporation (Nasdaq: PRSC ) ... financial advisor. , In ... strategic,options relating to, among other things, delevering its debt, growing ... UBS,Investment Bank has been retained in connection with selling certain,non-strategic ...
... Stylists, beauticians may be affected by phthalates in these ... -- Mothers exposed to a common hairspray chemical while ... born with an abnormally placed urinary opening, a new ... fragrances, and nail and hair products contain chemicals called ...
... are misaligned and point outward are at significantly ... adulthood, according to findings of a Mayo Clinic ... ( http://pediatrics.aappublications.org/cgi/content/full/122/5/1033 ), the official journal of the ... examined the medical records of 407 patients with ...
... it,s cheaper and less time-consuming than in-person visits, study ... counseling may be as effective as face-to-face counseling in ... University of Florida study included 234 obese women, ages ... Florida. , All the women completed a six-month weight-loss ...
... Public engagement practitioners from across the world are to ... be held in South Africa, organised by the Wellcome ... engage to empower" will take place from 2-5 ... Studies, KwaZulu-Natal. It will bring together practitioners working in ...
Cached Medicine News:Health News:Parents are the unsung heroes 2Health News:Providence Service Corporation Retains UBS Investment Bank as its Financial Advisor in Connection With the Sale of Certain Non-Strategic Assets 2Health News:Over-the-Phone Weight Loss Counseling Works 2Health News:International workshop aims to boost public engagement work in developing countries 2Health News:International workshop aims to boost public engagement work in developing countries 3
(Date:7/14/2014)... , 14 de julio de 2014 /PRNewswire-HISPANIC PR ... anunciar que Barry Epling , presidente de la ... CEO de la Compañía. El señor Epling es el ... que otorgó la licencia de su formulación, sus propiedades ... proveedor de apoyo financiero. "El señor ...
(Date:7/14/2014)... , July 14, 2014  Invivotek L.L.C., a ... pleased to announce that its animal research facility ... the Assessment and Accreditation of Laboratory Animal Care ... animals in science worldwide through voluntary accreditation and ... animal care and use in 38 countries. ...
(Date:7/14/2014)... July 14, 2014 Valeant Pharmaceuticals International, ... VRX) today announced it has filed a premerger ... 1976 (HSR) with the U.S. Federal Trade Commission ... Inc. (NYSE: AGN). About Valeant ... International, Inc. (NYSE/TSX: VRX) is a multinational specialty ...
Breaking Medicine Technology:BioAdaptives se prepara para el próximo paso 2BioAdaptives se prepara para el próximo paso 3Invivotek Awarded Full AAALAC Accreditation for Excellence in Laboratory Animal Care and Use 2Valeant Pharmaceuticals Submits HSR Filing Relating To Proposed Acquisition Of Allergan 2Valeant Pharmaceuticals Submits HSR Filing Relating To Proposed Acquisition Of Allergan 3Valeant Pharmaceuticals Submits HSR Filing Relating To Proposed Acquisition Of Allergan 4Valeant Pharmaceuticals Submits HSR Filing Relating To Proposed Acquisition Of Allergan 5
... PCI program is critical, CHICAGO, March 29 ... and successfully in medical centers without,on-site cardiac surgical ... to quality. These are the findings of the,largest ... have on-site,cardiac surgery to PCI programs that transfer ...
... days and out to 450 days in patients who ... either bare metal or drug-eluting stents, CHICAGO, March 29 ... and highly,statistically significant reduction in the risk of coronary stent,thrombosis ... fatal consequences - in patients who received a stent as,compared ...
Cached Medicine Technology:Study Finds PCI Safe, Effective Despite Off-Site Cardiac Surgery 2Study Finds PCI Safe, Effective Despite Off-Site Cardiac Surgery 3Study Finds PCI Safe, Effective Despite Off-Site Cardiac Surgery 4Study Results Show Investigational Drug, Prasugrel, Cuts Risk of Stent-Related Clots by More than Half Versus Clopidogrel 2Study Results Show Investigational Drug, Prasugrel, Cuts Risk of Stent-Related Clots by More than Half Versus Clopidogrel 3Study Results Show Investigational Drug, Prasugrel, Cuts Risk of Stent-Related Clots by More than Half Versus Clopidogrel 4Study Results Show Investigational Drug, Prasugrel, Cuts Risk of Stent-Related Clots by More than Half Versus Clopidogrel 5Study Results Show Investigational Drug, Prasugrel, Cuts Risk of Stent-Related Clots by More than Half Versus Clopidogrel 6Study Results Show Investigational Drug, Prasugrel, Cuts Risk of Stent-Related Clots by More than Half Versus Clopidogrel 7
The ACMI™ line of laparoscopic hand instruments is designed to provide a wide selection of popular surgical devices to meet procedural needs....
The Snap-In Snap-Out-II Tip Inserts offer a large variety of configurations....
The Snap-In Snap-Out-II Tip Inserts offer a large variety of configurations....
The Optima III line of laparoscopic hand instruments provides a well-crafted set of instruments designed for strength and durability....
Medicine Products: