Navigation Links
Metabolic protein plays unexpected role in tumor cell formation and growth
Date:11/6/2011

ression, which are essential for tumor formation, are conventionally thought to be regulated primarily by distinct signaling complexes," Lu said. The new findings integrate the two major mechanisms for regulating cancer cell growth by a key metabolic enzyme. "These two important regulatory processes are under the control of pyruvate kinase M2."

New insight into brain malignancies and cancer therapy

Beta-catenin activation that is independent of the Wnt signaling pathway have been observed in many types of cancer. This study reveals a critical mechanism underlying Wnt-independent beta-catenin activation and indicates that c-Src-phosphorylated beta-catenin and nuclear PKM2 are independent predictors of glioma malignancy.

The researchers analyzed brain tumors in 84 patients who had been treated with radiation and chemotherapy after surgery. Those who had low beta-catenin Y333 phosphorylation or low expression of PKM2 in the nucleus (28 cases each) had a median survival of 185 weeks and 130 weeks, respectively.

Median survival decreased for those who had high levels of beta-catenin phosphorylation or nuclear PKM2 expression (56 cases each) to 69.4 weeks and 82.5 weeks, respectively.

Findings include:

  • PKM2-dependent beta-catenin activation is instrumental in EGFR-promoted tumor cell proliferation and brain tumor development.
  • c-Src activity, beta-catenin Y333 phosphorylation, and PKM2 nuclear accumulation are positively correlated in human glioblastoma specimens.
  • Levels of beta-catenin phosphorylation and nuclear PKM2 are correlated with grades of glioma malignancy and prognosis.

Personalized therapy with Src inhibitors

One potential implication of their research is the potential use of c-Src-dependent beta-catenin Y333 phosphorylation levels as a biomarker for selecting patients for treatment.

"This finding is very important because EGFR-based therapy i
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Study identifies genetic basis of human metabolic individuality
2. VTT brings top metabolics experts to Finland
3. Bad Body Odor May Be Caused by Metabolic Disorder
4. Metabolic Syndrome Linked to Kidney Disease
5. Metabolic syndrome may cause kidney disease
6. Psychiatrists failing to adequately monitor patients for metabolic side-effects of prescribed drugs
7. The metabolic effects of antipsychotic drugs
8. Metabolic shift may offer early cancer clue
9. Increased metabolic rate may lead to accelerated aging
10. Researchers identify the metabolic signaling pathway responsible for dyslipidemia
11. Metabolic syndrome may increase risk for liver cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... ... ... opinion piece published July 28 by the Washington Post, the conventional wisdom that ... not be accurate. While this system may work for some people, the author notes that ... on the individual and at what point that person is in their weight loss journey. ...
(Date:8/3/2015)... PA (PRWEB) , ... August 03, 2015 , ... ... Africa , Infectious diseases researchers from the University of Pittsburgh School of Medicine ... rollout of HIV prevention drugs in sub-Saharan Africa. , A cooperative agreement ...
(Date:8/3/2015)... ... August 03, 2015 , ... ... fitness site and the largest online retailer of nutritional supplements, has officially ... is up for 11 awards in the following categories:, ...
(Date:8/3/2015)... ... August 03, 2015 , ... ... and Navigant Center for Healthcare Research and Policy Analysis show widespread support for ... respondents said they agreed or strongly agreed that the controversial law passed in ...
(Date:8/3/2015)... ... 2015 , ... A July 9 article from USA Today has ... to the American Dental Association. According to a study by the American Dental Association, ... in a single year to 2.2 million a year. Dentists and ADA officials all ...
Breaking Medicine News(10 mins):Health News:Article Dispelling Weight Loss Myth Correctly Emphasizes the Complicated and Difficult Nature of Weight Loss, Says Dr. Michael Feiz 2Health News:$5M Effort to Guide Use of HIV Prevention Meds in Africa 2Health News:$5M Effort to Guide Use of HIV Prevention Meds in Africa 3Health News:$5M Effort to Guide Use of HIV Prevention Meds in Africa 4Health News:BPI Sports is Nominated for 11 Different 2015 Bodybuilding.com Supplement Awards 2Health News:BPI Sports is Nominated for 11 Different 2015 Bodybuilding.com Supplement Awards 3Health News:Survey Finds Support for the Affordable Care Act Among Physician Leaders 2Health News:Survey Finds Support for the Affordable Care Act Among Physician Leaders 3Health News:Los Angeles Periodontists Comment on Rising Dental Emergency Room Trips 2Health News:Los Angeles Periodontists Comment on Rising Dental Emergency Room Trips 3
... ... Massachusetts child injury lawyer, Thomas M. Kiley. , ... (PRWEB) November 20, 2009 -- During the exciting weeks leading up to ... friends, and decorating their homes in the spirit of the season. Among all this holiday ...
... , ... is featured in The App Store What’s Hot List only one month after its initial ... Austin, TX (PRWEB) ... applications, announced today that its new iPhone and iPod Touch fitness application MySportTraining is featured ...
... , MADISON, N.J., Nov. 20 ... DGX ), the nation,s leading provider of employment-related ... from employees and job applicants in the general U.S. workforce ... from 2005 to the first half of 2009 that mirror ...
... Nov. 20 Masimo Corporation (Nasdaq: MASI ), the ... oximetry, today announced that its management is scheduled to present ... the New York Palace Hotel in New York on Tuesday, ... audiocast of the presentation will be available on the Masimo ...
... , , ARLINGTON, Va., Nov. 20 ... but the added demands of the season can also stress the ... unhealthy behaviors contribute to some of our country,s biggest health problems ... build up inside the body and manifest as back pain, neck ...
... ... operating costs, it is unusual for a company to reduce or eliminate the fee they ... cost of shipping... FREE with a minimum order. , ... (PRWEB) November 20, 2009--Brewer Company and Quick Medical have announced that ...
Cached Medicine News:Health News:Parents: Holiday Safety Tips from Massachusetts Child Injury Lawyer Thomas M. Kiley 2Health News:Parents: Holiday Safety Tips from Massachusetts Child Injury Lawyer Thomas M. Kiley 3Health News:VidaOne's New iPhone Fitness Application Featured in App Store What's Hot List 2Health News:VidaOne's New iPhone Fitness Application Featured in App Store What's Hot List 3Health News:New Hair Data Validate Sharp Downward Trend in Cocaine and Methamphetamine Positivity in General U.S. Workforce, According to Quest Diagnostics Drug Testing Index(TM) 2Health News:New Hair Data Validate Sharp Downward Trend in Cocaine and Methamphetamine Positivity in General U.S. Workforce, According to Quest Diagnostics Drug Testing Index(TM) 3Health News:New Hair Data Validate Sharp Downward Trend in Cocaine and Methamphetamine Positivity in General U.S. Workforce, According to Quest Diagnostics Drug Testing Index(TM) 4Health News:New Hair Data Validate Sharp Downward Trend in Cocaine and Methamphetamine Positivity in General U.S. Workforce, According to Quest Diagnostics Drug Testing Index(TM) 5Health News:New Hair Data Validate Sharp Downward Trend in Cocaine and Methamphetamine Positivity in General U.S. Workforce, According to Quest Diagnostics Drug Testing Index(TM) 6Health News:New Hair Data Validate Sharp Downward Trend in Cocaine and Methamphetamine Positivity in General U.S. Workforce, According to Quest Diagnostics Drug Testing Index(TM) 7Health News:New Hair Data Validate Sharp Downward Trend in Cocaine and Methamphetamine Positivity in General U.S. Workforce, According to Quest Diagnostics Drug Testing Index(TM) 8Health News:New Hair Data Validate Sharp Downward Trend in Cocaine and Methamphetamine Positivity in General U.S. Workforce, According to Quest Diagnostics Drug Testing Index(TM) 9Health News:New Hair Data Validate Sharp Downward Trend in Cocaine and Methamphetamine Positivity in General U.S. Workforce, According to Quest Diagnostics Drug Testing Index(TM) 10Health News:Masimo to Present at the 21st Annual Piper Jaffray Health Care Conference 2Health News:Holidays Bring Stress, Pains to Many; American Chiropractic Association Offers '12 Days of Health and Wellness' for a Healthy, Happy Season 2Health News:Brewer and Quick Medical Announce New Freight Policy 2Health News:Brewer and Quick Medical Announce New Freight Policy 3
(Date:8/3/2015)... YORK , Aug. 3, 2015   ... global pharmaceutical company Allergan plc is ... Deloitte and Intermountain Healthcare to include ... harness ConvergeHEALTH,s OutcomesMiner analytics platform to generate real-world ... outcomes. "We look forward to expanding ...
(Date:8/3/2015)... Aug. 3, 2015  Dr. Cal Robinson ... & Spine Center today, providing patients with ... chronic pain through psychological counseling and treatment programs. ... Fellowship-trained, certified medical psychologist with an extensive career ... experience ranges from assessment and treatment of behavioral ...
(Date:8/3/2015)... , Aug. 3, 2015  BioElectronics Corporation (OTC ... pain management, announced that Andrew J. Whelan , ... on his program "On Business" at 9am EDT on ... interview live, tune to: http://tunein.com/radio/Money-Matters-Boston-1120-s27548/ ... on the exceptional acceptance the company,s flagship product, ActiPatch ...
Breaking Medicine Technology:ConvergeHEALTH by Deloitte and Intermountain Healthcare Expand Real World Evidence Collaboration with Allergan to Focus on Women's Health 2ConvergeHEALTH by Deloitte and Intermountain Healthcare Expand Real World Evidence Collaboration with Allergan to Focus on Women's Health 3ConvergeHEALTH by Deloitte and Intermountain Healthcare Expand Real World Evidence Collaboration with Allergan to Focus on Women's Health 4Orthopaedic & Spine Center Introduces New Pain Psychologist 2UpTick News Wire Radio Show Will Interview BioElectronics' CEO Andrew Whelan 2
... GSK ) confirmed today that a joint advisory committee to ... remain on the market. Committee members voted for recommendations ranging from making ... warnings and restrictions (20) to withdrawal from the U.S. market (12).   ... "Following today,s recommendations, ...
... July 14 D3 Radiation Services announced today  that the ... reduce errors in the delivery of radiation therapy--as a Practice Quality Improvement ... , , ... radiation oncology physicists can order a comprehensive audit of their beam data ...
Cached Medicine Technology:GlaxoSmithKline Statement in Response to FDA Advisory Committees' Vote on Safety of Avandia® (rosiglitazone) 2GlaxoSmithKline Statement in Response to FDA Advisory Committees' Vote on Safety of Avandia® (rosiglitazone) 3GlaxoSmithKline Statement in Response to FDA Advisory Committees' Vote on Safety of Avandia® (rosiglitazone) 4eDataAudit Receives Approval from the American Board of Radiology 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: