Navigation Links
Metabolic protein launches sugar feast that nurtures brain tumors
Date:11/26/2012

anism for overexpression of PKM2 in glioblastoma. They found that EGF receptor activation turns on NF-?B, which leads to a series of events culminating in PKM2 gene activation.

PKM2 levels were measured in tumor samples from 55 glioblastoma patients treated with standard of care surgery, radiation and chemotherapy. The 20 with low PKM2 expression had a median survival of 34.5 months, compared to 13.6 months for the 35 patients with high levels of PKM2.

Level of PKM2 expression in 27 low-grade astrocytomas was about half of the expression found in higher grade glioblastomas.

"In these two papers, we show how PKM2 is overexpressed in tumors, how it gets into the nucleus, that nuclear entry is essential to tumor development, and identified potential drugs and a biomarker that could usefully treat people," Lu said.


'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Normal triglyceride levels in people of African descent may hinder diagnosis of metabolic syndrome
2. Study: Women not getting enough exercise; at risk of developing metabolic syndrome
3. Mutant Kras drives pancreatic cancer maintenance via metabolic pathways
4. VCU researchers identify changes in cholesterol metabolic pathways
5. Metabolic Cooking Review For Karine Losier and Dave Ruel's Diet And Cookbook Program Released
6. Bees shed light on human sweet perception and metabolic disorders
7. Metabolic protein wields phosphate group to activate cancer-promoting genes
8. Ancestral link places Mexican-Americans at greater risk for metabolic disease
9. New research uncovers diverse metabolic roles for PML tumor suppressor gene
10. Obesity and metabolic syndrome associated with impaired brain function in adolescents
11. Metabolic engineer synthesizes key breast milk ingredient, makes research possible
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Metabolic protein launches sugar feast that nurtures brain tumors
(Date:12/17/2014)... -- Expectant parents should leave prenatal picture-taking to medical ... Use of ultrasound imaging and heartbeat monitors to get ... agency warns. "Although there is a lack ... and heartbeat monitors, prudent use of these devices by ... FDA biomedical engineer, said in an agency news release. ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... America, and work commitment is a big reason why, new ... said Dr. Mathias Basner, an assistant professor of sleep and ... of Medicine. A time-use survey of nearly 125,000 Americans, ... main activity exchanged for sleep. Short sleepers -- those who ...
(Date:12/15/2014)... 15, 2014 South Florida’s leading urgent care ... can be a daze of hassle, hustle, and bustle that ... decking halls, to burns when making special meals and heartburn ... can happen at any time. To prevent this season of ... made a list of helpful and healthful holiday tips to ...
(Date:12/15/2014)... News) -- Expert pilots process visual information more efficiently ... better decisions during landings, a new study shows. ... pilots to master, and 36 percent of all airplane ... final approach and landing. Researchers monitored the brain ... pilots while they were at the controls of a ...
(Date:12/15/2014)... 15, 2014 At the leading, long-established ... AutismOne and Focus Autism will welcome ... research on the effects of toxins to children’s health, ... information. , Luminaries such as Dr. Lucija Tomljenovic ... with esteemed, credentialed colleagues of the United States to ...
Breaking Medicine News(10 mins):Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:Study Shows Why Expert Pilots Are Experts 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3
... and vision assessments provided by InfantSEE(R) ProgramCHARLESTON, W.Va., ... of children with eye and vision problems across ... appointments to no-cost, comprehensive eye and vision assessments ... age through InfantSEE(R). InfantSEE(R), a public health program ...
... New York, N.Y. April 28, 2009 Peripheral arterial disease ... plaque and blood supply to the legs is reduced, affects eight ... because it can limit the ability to walk and exercise, it ... increases the chance of having a heart attack or stroke. Coronary ...
... text to speech instantly converts Word, PDF, PowerPoint, Excel and Web ... ... NJ (PRWEB) April 28, 2009 -- iSpeech.org, text to speech software ... to anyone using the Box.net platform. The integration allows Box customers ...
... Health Care ReformWASHINGTON, April 28 Private-sector strategies ... an essential component of comprehensive health care reform, ... AHIP hosted a press conference today to highlight ... to reward quality and spur improvement."There is widespread ...
... membership organizations today released Guidelines for Patient Centered ... the American Academy of Family Physicians (AAFP), the ... of Physicians (ACP) and the American Osteopathic Association ... pediatrician, family physician, internist and osteopathic physician members ...
... studies have shown that depression is associated with an increased ... clear. , Now, researchers at Rush University Medical Center have ... fat, the kind of fat packed between internal organs at ... risk of cardiovascular disease and diabetes. , The study is ...
Cached Medicine News:Health News:West Virginia Optometrists Partner With Sens. Byrd and Rockefeller, U.S. House Leaders in Improving Infant Eye and Vision Care 2Health News:West Virginia Optometrists Partner With Sens. Byrd and Rockefeller, U.S. House Leaders in Improving Infant Eye and Vision Care 3Health News:West Virginia Optometrists Partner With Sens. Byrd and Rockefeller, U.S. House Leaders in Improving Infant Eye and Vision Care 4Health News:West Virginia Optometrists Partner With Sens. Byrd and Rockefeller, U.S. House Leaders in Improving Infant Eye and Vision Care 5Health News:West Virginia Optometrists Partner With Sens. Byrd and Rockefeller, U.S. House Leaders in Improving Infant Eye and Vision Care 6Health News:West Virginia Optometrists Partner With Sens. Byrd and Rockefeller, U.S. House Leaders in Improving Infant Eye and Vision Care 7Health News:West Virginia Optometrists Partner With Sens. Byrd and Rockefeller, U.S. House Leaders in Improving Infant Eye and Vision Care 8Health News:Arterial disease of the leg frequently overlooked in patients with heart disease 2Health News:iSpeech.org Makes Box.net Talk Aloud 2Health News:New Health Plan Payment Models Are Improving Patient Quality and Safety 2Health News:New Health Plan Payment Models Are Improving Patient Quality and Safety 3Health News:New Health Plan Payment Models Are Improving Patient Quality and Safety 4Health News:Guidelines for medical home demonstrations released by major physician groups 2Health News:Guidelines for medical home demonstrations released by major physician groups 3Health News:Depression linked with accumulation of visceral fat 2
(Date:12/17/2014)... , Dec. 17, 2014  Beamz Interactive, ... interactive music products, today announced that it has ... leading manufacturer and supplier of innovative prosthetic, orthotic ... As part of the agreement, RSL Steeper will ... solution specifically configured for use within UK residential ...
(Date:12/17/2014)... ANGELES , Dec. 17, 2014  ImmunoCellular ... the US Patent and Trademark Office (USPTO) has ... ICT-107, a dendritic cell-based immunotherapeutic vaccine targeting six ... The claims of US Patent No. 8,871,211, which ... neural cancer by administering a dendritic cell composition ...
(Date:12/17/2014)... Mass. , Dec. 17, 2014  RXi ... biotechnology company focused on discovering, developing and commercializing ... RNA-targeted technologies, today announced completion of enrollment in its ... from the 3-month observations confirmed the 1-month findings ... Logo - http://photos.prnewswire.com/prnh/20130917/NE80755LOGO ...
Breaking Medicine Technology:Beamz Interactive, Inc. Signs UK Distribution Agreement with RSL Steeper Limited 2Beamz Interactive, Inc. Signs UK Distribution Agreement with RSL Steeper Limited 3ImmunoCellular Therapeutics Announces Issuance of Key Patent For ICT-107 Cancer Vaccine 2RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 2RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 3RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 4RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 5
... NEW YORK, March 20, 2012  Faruqi & Faruqi, ... investigating potential securities fraud at ZELTIQ Aesthetics, Inc. ... (Logo: http://photos.prnewswire.com/prnh/20120119/MM38856LOGO  ) Faruqi ... misled investors by failing to disclose material information ...
... WASHINGTON, March 20, 2012  At a public event ... Fight AIDS, Tuberculosis and Malaria and Friends of ... spotlighted the contributions of public-private partnerships to the ... delivery, to supplying much-needed resources, to mobilizing consumer ...
Cached Medicine Technology:Faruqi & Faruqi, LLP Announces Investigation of ZELTIQ Aesthetics, Inc. 2Global Fund Celebrates Efforts of Partners Chevron, The Coca-Cola Company, (RED) and PEPFAR at Capitol Hill Event 2Global Fund Celebrates Efforts of Partners Chevron, The Coca-Cola Company, (RED) and PEPFAR at Capitol Hill Event 3Global Fund Celebrates Efforts of Partners Chevron, The Coca-Cola Company, (RED) and PEPFAR at Capitol Hill Event 4
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: