Navigation Links
Metabolic molecule drives growth of aggressive brain cancer
Date:6/13/2013

sis.

Little is known, however, about the metabolic pathways that drive the growth of individual glioblastoma subtypes knowledge that is crucial for developing novel and effective targeted therapies that might improve treatment for these lethal tumors.

For this study, Nakano and his collaborators used cancer cells from 40 patients with high-grade gliomas, focusing on tumor cells with a stem-cell signature. The researchers then used microarray analysis and pre-clinical animal assays to identify two predominant glioblastoma subtypes, proneural and mesenchymal.

Key technical findings include:

  • Genes involved in glycolysis and gluconeogenesis, particularly ALDH1A3, were significantly up-regulated in mesenchymal glioma stem cells compared to proneural stem cells;
  • Mesenchymal glioma stem cells show significantly higher radiation resistance and high expression of DNA-repair genes;
  • Radiation induces transformation of proneural glioma stem cells into mesenchymal-like glioma stem cells that are highly resistant to radiation treatment; inhibiting the ALDH1 pathway reverses this resistance.
  • Inhibiting ALDH1A3-mediated pathways slows the growth of mesenchymal glioma stem cells and might provide a promising therapeutic approach for glioblastomas with a mesenchymal signature.

"Overall, our data suggest that a novel signaling mechanism underlies the transformation of proneural glioma stem cells to mesenchymal-like cells and their maintenance as stem-like cells," Nakano says. Currently, their discoveries are in provision patent application, led by the Technology Licensing Office at University of Pittsburgh.


'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Metabolic PET imaging provides earlier warning of coronary disease
2. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Offer Improved hCG Diets to Counteract Metabolic Slowdown
3. Roundworm quells obesity and related metabolic disorders
4. Metabolic disorders predict the hardening of the arterial walls already in childhood
5. Epoxide hydrolase inhibition and Thiazolidinediones: A therapy for cardiometabolic syndrome
6. Monounsaturated fats reduce metabolic syndrome risk
7. Monosaturated fats reduce metabolic syndrome risk
8. Altman Fitness Launches the Metabolic Typing - Customized Nutrition Plan
9. EU funds research project on obesity and metabolic complications
10. Selexis SA Announces Publication in Metabolic Engineering of Data Demonstrating Improvement of Therapeutic Protein Secretion with Engineered CHO Cells
11. Recon 2 modeling may help tailor treatments for patients with metabolic diseases, cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... 2014 Dynamic health trends, changing ... in the Bread Production industry over the past ... moderate their consumption of a variety of industry ... shrunk the market for white loaf bread and ... by introducing more nutritious products to attract health-conscious ...
(Date:9/30/2014)... September 30, 2014(BRONX, NY)Medications are the leading cause of ... analysis of death certificates from 1999 to 2010, conducted ... and Albert Einstein College of Medicine of Yeshiva ... Journal of Allergy and Clinical Immunology , also ... was particularly high among older people and African-Americans and ...
(Date:9/30/2014)... NV (PRWEB) September 30, 2014 Fat ... nutrition specialist and best-selling author Mike Geary that is helping ... transform their body into a fat-burning machine in less than ... an investigative review. , “In our culture that is ... be hard to decipher what is really fact and fiction ...
(Date:9/30/2014)... Eagan, Minn. (PRWEB) September 30, 2014 ... trips to the apple orchard, pumpkin patch or annual ... season for fast-spreading viruses – like the respiratory infection ... cold in most children, a small percentage – especially ... severe symptoms. Increased concern about the Enterovirus is prompting ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 A group of ... to combat an epidemic that, left unchecked, could create a ... are not headed to Africa. John Rogers, the Executive Director ... North Korea to fight a disease most think mankind conquered ... some 80 years ago is on the comeback in several ...
Breaking Medicine News(10 mins):Health News:Bread Production in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Bread Production in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:Comprehensive Study of allergic deaths in US finds medications are main culprit 2Health News:Fat Burning Kitchen: Review Exposes Mike Geary’s 24-Hour Diet Transformation for Helping the Body Burn Fat Through a Natural Diet 2Health News:Fat Burning Kitchen: Review Exposes Mike Geary’s 24-Hour Diet Transformation for Helping the Body Burn Fat Through a Natural Diet 3Health News:As Hospitals Combat Enterovirus Outbreaks, Patients and Families Turn to “Virtual Visits” with CaringBridge 2Health News:US Delegation Heads to North Korea to Combat Tuberculosis Epidemic 2
... Assembly elected new officers and members of its national board of ... Conference in Washington, D.C.New officers include:, , ... Director of YWCA York, Pennsylvania , ... Chicago, Illinois , Secretary: ...
... is standing up against insurance companies and big business , ... New ... lawyers can have a tough time against large pocketed companies such ... these monsters want the public to believe it is they who are ...
... and experts will gather in New Orleans on June ... health and property damage controversy involving building materials: ... for two teleconferences dealing with the insurance implications on ... According to the Consumer Product Safety Commission, at least ...
... For 7-year-old Alexander, it,s meant orthotics and physical therapy ... 7-year-old Rebecca, it,s an insulin pump for her Type ... cerebral palsy, it,s a wheelchair.All these children and more ... the UnitedHealthcare Children,s Foundation (UHCCF) in recent years to ...
... CME LL C ... Initiatives. In her new role, DeMatteo will guide the ... through activities founded on proven learning adult principles, delivered ... CME LLC more ...
... Pa., May 12 The Pennsylvania Department of Aging and ... a 15-member Quality Council that will advise on new policies ... services. "Many older citizens and those with disabilities prefer to ... nursing facility -- so we want to make sure that ...
Cached Medicine News:Health News:YWCA USA Elects New National Leadership Team 2Health News:Manhattan Personal Injury Attorney Blames Insurance Industry For Negative Perception Of Civil Justice System 2Health News:Chinese Drywall Litigation Subject of Conference and Two Teleconferences 2Health News:UnitedHealthcare Children's Foundation To Award More Medical Grants for Child Health Care Needs in Connecticut 2Health News:Ann Marie DeMatteo Joins CME LLC as Vice President of Educational Initiatives, Drives Innovative Programming Approaches 2Health News:Pennsylvania Council Formed to Advise on Improving Services to Older Adults, People with Disabilities 2
(Date:9/30/2014)... 30, 2014 Valeant Pharmaceuticals International, Inc. (NYSE: ... that the company,s Bridgewater, New Jersey ... Food and Drug Administration (FDA) relating to an inspection ... to Sculptra Aesthetic injectable, which was divested to Galderma ... management of Valeant,s contract manufacturers (rather than Valeant,s own ...
(Date:9/30/2014)... 30, 2014 The Eastern European medical device ... providers as well as new medical-device manufacturers are constantly ... looking at ways to reduce the cost incurred for ... one of the effective means to achieve this target. ... in Eastern European and provides profiles of key distributors ...
(Date:9/30/2014)... Sept. 30, 2014   Decision Resources Group ... data, anemic chronic kidney disease non-dialysis (CKD-ND) patients ... (ESA) medication. In addition, one-year persistency is similar ... Other key findings from the report entitled ... of Erythropoiesis Stimulating Agents in Late Stage Chronic ...
Breaking Medicine Technology:Valeant Pharmaceuticals' Bridgewater Location Receives Warning Letter From FDA 2Medical Technologies Distributor Profiles in Eastern Europe 2Medical Technologies Distributor Profiles in Eastern Europe 3Persistency is Low for Late-Stage Anemic CKD Non-Dialysis Patients Treated with Erythropoiesis-Stimulating Agents 2Persistency is Low for Late-Stage Anemic CKD Non-Dialysis Patients Treated with Erythropoiesis-Stimulating Agents 3
... on 01/05/2012 of Santa Barbara physician Dr. Julio Diaz ... overdose deaths from prescription medications. According to one of ... centers, Dr. Diaz,s arrest points to the dangers both ... of finding a physician who will prescribe medication for ...
... PHILADELPHIA, January 10, 2012 Shire plc (LSE: ... company, announced today that it has acquired the rights to ... States (US) in an agreement  with Janssen Pharmaceutica N.V.  Terms ... a prokinetic, is part of Shire,s gastrointestinal (GI) portfolio in ...
Cached Medicine Technology:Arrest of California Doctor Coincides with Uptick in Prescription Drug Overdoses 2Shire Acquires US Rights to Resolor® (prucalopride) 2Shire Acquires US Rights to Resolor® (prucalopride) 3Shire Acquires US Rights to Resolor® (prucalopride) 4
... need for a compact RFID printing solution ... point of use, the R2844-Z printer/encoder is ... industry! Designed for printing and encoding smart ... the R2844-Z meets the needs of applications ...
... System includes real time location ... RFID, telemetery and choke-point visibility ... infrastructure. Health Trax Standards-based applications ... in in door and outdoor ...
... The WatchMate system is designed to protect ... undetected and becoming lost or injured. Such ... Alzheimer's etc., or have suffered a head ... bracelet on their wrist or ankle, and ...
... Smart™ Labels have a direct thermal ... Instruments Tag-it™ HF-I transponder. When processed ... text and other graphics may be ... data is programmed to the RFID ...
Medicine Products: