Navigation Links
Metabolic molecule drives growth of aggressive brain cancer
Date:6/13/2013

COLUMBUS, Ohio A study led by researchers at The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James) has identified an abnormal metabolic pathway that drives cancer-cell growth in a particular glioblastoma subtype. The finding might lead to new therapies for a subset of patients with glioblastoma, the most common and lethal form of brain cancer.

The physician scientists sought to identify glioblastoma subtype-specific cancer stem cells. Genetic analyses have shown that high-grade gliomas can be divided into four subtypes: proneural, neural, classic and mesenchymal.

This study shows that the mesenchymal subtype is the most aggressive subtype, that it has the poorest prognosis among affected patients, and that cancer stem cells isolated from the mesenchymal subtype have significantly higher levels of the enzyme ALDH1A3 compared with the proneural subtype.

The findings, published recently in the Proceedings of the National Academy of Sciences, show that high levels of the enzyme drive tumor growth.

"Our study suggests that ALDH1A3 is a potentially functional biomarker for mesenchymal glioma stem cells, and that inhibiting that enzyme might offer a promising therapeutic approach for high-grade gliomas that have a mesenchymal signature," says principal investigator Ichiro Nakano, MD, PhD, associate professor of neurosurgery at the OSUCCC James. "This indicates that therapies for high-grade gliomas should be personalized, that is, based on the tumor subtype instead of applying one treatment to all patients," he says.

The National Cancer Institute estimates that 23,130 Americans will be diagnosed with brain and other nervous system tumors in 2013, and that 14,000 people will die of these malignancies. Glioblastoma accounts for about 15 percent of all brain tumors, is resistant to current therapies and has a survival as short as 15 months after diagno
'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Metabolic PET imaging provides earlier warning of coronary disease
2. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Offer Improved hCG Diets to Counteract Metabolic Slowdown
3. Roundworm quells obesity and related metabolic disorders
4. Metabolic disorders predict the hardening of the arterial walls already in childhood
5. Epoxide hydrolase inhibition and Thiazolidinediones: A therapy for cardiometabolic syndrome
6. Monounsaturated fats reduce metabolic syndrome risk
7. Monosaturated fats reduce metabolic syndrome risk
8. Altman Fitness Launches the Metabolic Typing - Customized Nutrition Plan
9. EU funds research project on obesity and metabolic complications
10. Selexis SA Announces Publication in Metabolic Engineering of Data Demonstrating Improvement of Therapeutic Protein Secretion with Engineered CHO Cells
11. Recon 2 modeling may help tailor treatments for patients with metabolic diseases, cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... 31, 2014 Fundraising support for fighting cancer ... than losses. At noon on Monday, November 10 in the ... (SSMH), greater than 20 Susquehanna Health (SH) employees and community ... awareness and funds for the new Cancer Center at SSMH. ... for this act of love and support to which many ...
(Date:10/31/2014)... first study of its kind, Rice University researchers have ... cause cancer cells to become metastatic. The research reveals ... cells to both migrate and form new tumors. Researchers ... drugs that interfere with the genetic switches that cancer ... circulating tumor cells -- two of the main players ...
(Date:10/31/2014)... October 31, 2014 The Memory Healer review ... by Alexander Lynch, whose father suffered from Alzheimer's disease. ... moment, caused by his father's disease. His father pointed a ... the crucial moment when the author of this method understood ... , The Memory Healer program is based on years ...
(Date:10/31/2014)... CA (PRWEB) October 31, 2014 ... also has amazing health effects for practitioners. ... by a Doctor of Science and Movement specializing ... his dedication to pelvic floor reeducation that traditional ... urinary incontinence, Diastasis Recti, Prolepses, etc. , The ...
(Date:10/31/2014)... Lake City, UT (PRWEB) October 31, 2014 ... announce the new Activz Silver line offering ... and cleansing wipes. For over a century, silver has ... formula found in Activz Silver products is the most ... U.S. patents, has a unique chemical structure that supports ...
Breaking Medicine News(10 mins):Health News:Susquehanna Health Soldiers + Sailors Memorial Hospital Razing Heads to Fight Cancer 2Health News:Decoding the emergence of metastatic cancer stem cells 2Health News:Decoding the emergence of metastatic cancer stem cells 3Health News:"Memory Healer" Review Reveals a New Natural Remedy Guide for Managing Memory Loss 2Health News:Super Models and European Celebrities’ Secret Flat Tummy System Comes to America 2Health News:Super Models and European Celebrities’ Secret Flat Tummy System Comes to America 3Health News:New Collection of Nano-particle Natural Silver Products by Activz Whole-Food Nutrition 2Health News:New Collection of Nano-particle Natural Silver Products by Activz Whole-Food Nutrition 3Health News:New Collection of Nano-particle Natural Silver Products by Activz Whole-Food Nutrition 4
... News) -- Heart disease patients with high blood pressure ... drugs (NSAIDs) are at greater risk for heart attack, ... NSAIDS include popular medications such as such as aspirin, ... are published in the July issue of The ...
... Gordon HealthDay Reporter , THURSDAY, July 14 (HealthDay News) ... you probably memorized a lot more information -- such as phone ... a new study has found that the brain just doesn,t remember ... been saved on a computer. What people may remember, however, is ...
... transplant survival more than doubled in recent years for ... Research Hospital, with patients who lacked genetically matched donors ... to be the best ever reported for leukemia patients ... expected to make transplantation a treatment option for more ...
... can be admirable or romantic. In a cancerous tumor, it ... cells that have strayed from their original location to insinuate their ... way of determining whether a newly formed tumor is more likely ... the body. In a study published in the July 12 ...
... percent of patients with primary or metastatic cancer ... seizures, confusion, difficulty swallowing and visual disturbances. These ... brain invasion from cancer called neoplastic meningitis. Santosh ... San Diego School of Medicine and colleagues have ...
... 14 (HealthDay News) -- New research suggests that training ... other people could help them overcome anxiety and prevent ... Oxford University in the United Kingdom found that training ... negative interpretations of unclear social situations could influence how ...
Cached Medicine News:Health News:Certain Painkillers May Raise Odds of Stroke, Heart Attack: Study 2Health News: Can You Google Your Memory? 2Health News: Can You Google Your Memory? 3Health News: Can You Google Your Memory? 4Health News:Bone marrow transplant survival more than doubles for young high-risk leukemia patients 2Health News:Bone marrow transplant survival more than doubles for young high-risk leukemia patients 3Health News:Early-stage melanoma tumors contain clues to metastatic potential 2Health News:Early-stage melanoma tumors contain clues to metastatic potential 3Health News:Novel combined therapy extends life, diminishes pain in brain cancer patients 2Health News:Training in Positive Thinking May Help Anxious Teens 2
(Date:10/31/2014)... , Oct. 31, 2014  Zacks.com announces the list of stocks ... analysts discuss the latest news and events impacting stocks and the ... AMGN - Free Report ), Celgene (Nasdaq: ... BIIB - Free Report ), Market Vectors Biotech ETF ... S&P Biotech ETF (AMEX: XBI - Free Report ...
(Date:10/31/2014)... , Oct. 31, 2014 /CNW Telbec/ - ... with its strategic plan, for accelerated growth in terms ... 32.6% and revenues reached $17,862,341. Net income amounted to ... threshold for the first time in the Company,s history. ... the Company joined the forces of its subsidiaries, merging ...
(Date:10/31/2014)... 2014 Though therapies are in their nascent ... show an annual increase of 16.2% over the 2010-2020 ... billion, according to Kalorama Information,s report, Stem Cell ... therapeutics that have gained or are expected to gain ... developers tackle ever more complicated conditions, stem cell therapies ...
Breaking Medicine Technology:The Zacks Analyst Blog Highlights: Amgen, Celgene, Biogen Idec, Market Vectors Biotech ETF and SPDR S&P Biotech ETF 2The Zacks Analyst Blog Highlights: Amgen, Celgene, Biogen Idec, Market Vectors Biotech ETF and SPDR S&P Biotech ETF 3The Zacks Analyst Blog Highlights: Amgen, Celgene, Biogen Idec, Market Vectors Biotech ETF and SPDR S&P Biotech ETF 4The Zacks Analyst Blog Highlights: Amgen, Celgene, Biogen Idec, Market Vectors Biotech ETF and SPDR S&P Biotech ETF 5The Zacks Analyst Blog Highlights: Amgen, Celgene, Biogen Idec, Market Vectors Biotech ETF and SPDR S&P Biotech ETF 6The Zacks Analyst Blog Highlights: Amgen, Celgene, Biogen Idec, Market Vectors Biotech ETF and SPDR S&P Biotech ETF 7Results for the fourth quarter and the fiscal year ended June 30, 2014 - Ergoresearch reports solid 2014 annual results 2Results for the fourth quarter and the fiscal year ended June 30, 2014 - Ergoresearch reports solid 2014 annual results 3Results for the fourth quarter and the fiscal year ended June 30, 2014 - Ergoresearch reports solid 2014 annual results 4Results for the fourth quarter and the fiscal year ended June 30, 2014 - Ergoresearch reports solid 2014 annual results 5Report: Stem Cell Technologies Market Growing 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: