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Metabolic factors may play a role in risk for breast cancer
Date:6/30/2009

results show possible mechanisms that might explain the observation that increased weight is a risk factor for postmenopausal breast cancer.

"We have assumed that the relationship between weight and breast cancer risk is due to increased circulating estrogens among postmenopausal women who are overweight or obese," he said. "An alternative explanation is explored here: that some other aspect of the metabolic syndrome might be involved, such as growth-stimulating effects of insulin, or insulin-like growth factors."

Based on the results of this study, Byers stated that researchers now need to look more closely at dynamic changes in insulin over time, in factors tied to inflammation, and in the specific ways in which estrogen metabolism is tied to features of the metabolic syndrome.

"Though estrogens are produced in adipose tissues, just how these are metabolized in various subgroups of women needs better study," he said. "In addition, the hyper-inflammatory state of obesity and the metabolic syndrome need to be better described relative to cancer risk."


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Contact: Tara Yates
tara.yates@aacr.org
267-646-0558
American Association for Cancer Research
Source:Eurekalert

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