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Metabolic biomarkers for preventive molecular medicine
Date:12/4/2012

increased levels of telomerase those that age more slowly, according to a study published recently by the Blasco laboratory in the journal EMBO Molecular Medicine, they observed that the metabolic footprint was very similar to that of the youngest mice. When they studied mice with telomerase deficiencies those that aged more quickly, they observed a metabolic profile very similar to that of older animals.

Recent studies in humans indicate a possible relationship between the metabolism and life expectancy. "Our large-scale analysis, that analyses a larger amount of metabolites than has ever been studied before, validates the theory that the metabolome faithfully shows cells' biological clocks", says Mato.

NEW BIOMARKERS TO EVALUATE THE STATE OF HEALTH

Ageing is characterised in large part by metabolic decline that implies loss of hepatic, renal, coronary or cardiac function, as well as an increased risk of suffering cancer. In fact, some of the 48 metabolites identified in the study have previously been related to illnesses associated with age, such as Alzheimer's or cardiovascular diseases.

The results of this research may be useful for predicting the overall state of health in humans, via the extraction of a small blood sample. They might also be useful for preventing illnesses related to the passage of time, which make up the majority of deadly diseases in developed countries.

From these results, the researchers are also looking into searching for diagnostic biomarkers that are associated to high-impact socioeconomic illnesses such as diabetes, obesity or cardiovascular diseases.


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Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

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