Navigation Links
Metabolic biomarkers for preventive molecular medicine
Date:12/4/2012

One of the big challenges of biomedicine is understanding the origin of illnesses in order to improve early detection and significantly increase recovery rates, as well as being able to do what CNIO researchers call preventive molecular medicine, which consists of identifying those individuals who have a greater molecular risk of suffering certain pathologies in order to prevent them. The ageing of the organism, and therefore of the cells and tissues it is made of, represents the greatest risk factor for the majority of developed-world illnesses, including cancer.

A team of scientists from the Spanish National Cancer Research Centre (CNIO), led by its director, Mara Blasco, together with Jose M. Mato, the director of the Center for Cooperative Research in Biosciences (CIC bioGUNE), has shown that the metabolic profile of an organism indicates its level of cellular ageing and the general state of health in mice. These results could be of great use for preventive molecular medicine, given that they would indicate the state of health quickly and in a non-invasive manner, and that they would help to prevent illnesses or to diagnose them at the earliest stages.

The metabolism is one of the processes which best defines the general state of organisms. With the aim of studying a possible relationship between the metabolism and ageing, the authors of this study have used a new methodology that, based on liquid chromatography techniques and nuclear magnetic resonance, has made it possible to study up to 1.500 metabolitesintermediate products of the metabolismin 130 mice using very small samples just 5-10 l of blood serum.

"Using this new technique, we have seen that the metabolic profile of mice depends on their age; specifically, we have found 48 metabolites that vary very significantly with age", says CNIO researcher Bruno Bernardes de Jess, one of the study's authors.

When researchers carried out the same analysis in mice that had
'/>"/>

Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Metabolic protein launches sugar feast that nurtures brain tumors
2. New technology for a more efficient treatment of Pompe disease and other metabolic disorders
3. Moffitt Cancer Center researchers identify novel metabolic programs driving aggressive brain tumors
4. Metabolic syndrome makes a difference in hormone therapy risk
5. In obesity, a micro-RNA causes metabolic problems
6. Obese people can be metabolically healthy and in good shape
7. Study links breast cancer risk to early-life diet and metabolic syndrome
8. Metabolic engineer synthesizes key breast milk ingredient, makes research possible
9. Obesity and metabolic syndrome associated with impaired brain function in adolescents
10. New research uncovers diverse metabolic roles for PML tumor suppressor gene
11. Ancestral link places Mexican-Americans at greater risk for metabolic disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... ... 31, 2015 , ... Last week, the Mesothelioma Applied Research ... be accessed by visiting http://www.curemeso.org/store . , “Our new store features a ... whenever a product is purchased, the Meso Foundation receives a $5.00 donation,” said ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... There’s no ... possible, even when it comes time to cook the next meal, making July the ... July by practicing best grilling tips and recipes. , Make the next cookout different ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... Coco Libre ... athletes, judges, media, and VIPs at the 2015 Vans US Open of Surfing, July ... water that can claim “no added sugar” on the market, is a natural choice ...
(Date:7/31/2015)... , ... July 31, 2015 , ... According to the article published July ... the Pasadena courthouse was contained and extinguished by the city’s fire department before it caused ... building at the time of the fire, and it was a fire alarm system that ...
(Date:7/31/2015)... ... July 31, 2015 , ... ... pharmaceutical negligence is now available online at ( http://www.lawline.com/cle/course/its-a-wonderful-life-if-you-receive-the-right-meds-a-discussion-of-pharmaceutical-negligence ). Mr. ... approval rating from the nationwide audience. The course focused on the ...
Breaking Medicine News(10 mins):Health News:Mesothelioma Organization Launches New Store 2Health News:Mesothelioma Organization Launches New Store 3Health News:King Kullen Honors National Hot Dog and Blueberry Month 2Health News:King Kullen Honors National Hot Dog and Blueberry Month 3Health News:Coco Libre Brings Eco-conscious Hydration to Vans US Open of Surfing 2Health News:Article on Recent Pasadena Courtroom Fire Highlights the Effectiveness of Fire Alarm Systems, Says Fire Protection Group Inc 2Health News:Article on Recent Pasadena Courtroom Fire Highlights the Effectiveness of Fire Alarm Systems, Says Fire Protection Group Inc 3Health News:Re-Broadcast of Nationally Renowned Trial Attorney Jason T. Brown's Lecture on Pharmaceutical Negligence Now Available 2
... Reporter , WEDNESDAY, Oct. 5 (HealthDay News) -- Scientists ... in humans. Though this isn,t the first "mouse ... closer to mirroring all of the core symptoms of ... Matthew Anderson, an assistant professor of neurology and pathology ...
... , WEDNESDAY, Oct. 5 (HealthDay News) -- ... during pregnancy are at increased risk for fertility problems ... This study from the U.S. National Cancer Institute "illustrates ... agents may take many decades to be fully appreciated ...
... of Health Fogarty International Center has awarded $1.1 million to ... program that for the last 10 years has been training ... suicide. "Across China, a cadre of people has developed ... chair of the Medical Center,s Department of Psychiatry and principal ...
... Reporter , WEDNESDAY, Oct. 5 (HealthDay News) -- The death ... cantaloupes has risen to 18, and a total of 100 ... for Disease Control and Prevention reported late Tuesday. The ... recalled Sept. 14, more cases might still emerge since ...
... young people with melanoma, a deadly form of skin cancer, ... invasive disease than adults. The study, published online Oct. ... be the first to compare disease spread in children and ... childhood and adult melanoma, the researchers say. The ...
... possible new target for breast cancer therapy comes from ... growth and metastasis of breast tumors, as reported in ... peer-reviewed journal published by Mary Ann Liebert, Inc. The ... at http://www.liebertpub.com/jir . Qifang Zhang and Andrew ...
Cached Medicine News:Health News:Scientists Engineer Mice That Have Autism 2Health News:Scientists Engineer Mice That Have Autism 3Health News:Health Woes Still Strike Women Exposed to Banned Pregnancy Drug 2Health News:NIH funds continued research in suicide prevention in China 2Health News:NIH funds continued research in suicide prevention in China 3Health News:NIH funds continued research in suicide prevention in China 4Health News:18 Deaths From Cantaloupe-Linked Listeria Outbreak: CDC 2Health News:18 Deaths From Cantaloupe-Linked Listeria Outbreak: CDC 3Health News:Invasive melanoma may be more likely in children than adults 2
(Date:7/31/2015)... 2015  In today,s ever-changing marketplace, call centers must ... increasingly connected, and increasingly impatient with slow service. The ... channels and tools is driving call centers to explore ... According to research by benchmarking firm, Best Practices, ... in a call center study realize the impact of ...
(Date:7/31/2015)... , July 31, 2015 Today, the ... (NABP ® ) issued a report urging greater ... action is taken against websites illegally selling medications ... Drug Outlet Identification Program Progress Report for State ... thousands of websites illegally distribute medications and ...
(Date:7/31/2015)... July 31, 2015  Boston Children,s Hospital physicians ... 3D printing of their anatomy before undergoing high-risk ... malformations (abnormalities in the brain,s blood vessels) that ... today in the Journal of Neurosurgery: Pediatrics ... printing and synthetic resins to create custom, high-fidelity ...
Breaking Medicine Technology:Best Practices in Building World-Class Consumer & Over-the-Counter Call Centers 2NABP Stresses Need for Accountability in Enforcing Internet Policies to Protect the Public From Illegal Online Drug Sellers 2NABP Stresses Need for Accountability in Enforcing Internet Policies to Protect the Public From Illegal Online Drug Sellers 33D Printing Helps Doctors Rehearse Complex Brain Procedures 23D Printing Helps Doctors Rehearse Complex Brain Procedures 33D Printing Helps Doctors Rehearse Complex Brain Procedures 4
Bone cement with Gentamicin 2.5%....
... Techno-Aide provides the highest level of ... quality lead protective eyewear. Consistent ... tolerance allowed. Mfg supervised by Licensed ... lens meet or exceed standards for ...
... large designer goggle includes a ... providing a more comfortable, even ... The head strap design is ... The acrylic side shields provide ...
... base metal with gold electro-plate, the flex-temple ... adjustable non-slip silicon nose pads for maximum ... fitted lead sheet side shields that create ... increased scatter radiation protection. (Temples on this ...
Medicine Products: