Navigation Links
Metabolic biomarkers for preventive molecular medicine
Date:12/4/2012

One of the big challenges of biomedicine is understanding the origin of illnesses in order to improve early detection and significantly increase recovery rates, as well as being able to do what CNIO researchers call preventive molecular medicine, which consists of identifying those individuals who have a greater molecular risk of suffering certain pathologies in order to prevent them. The ageing of the organism, and therefore of the cells and tissues it is made of, represents the greatest risk factor for the majority of developed-world illnesses, including cancer.

A team of scientists from the Spanish National Cancer Research Centre (CNIO), led by its director, Mara Blasco, together with Jose M. Mato, the director of the Center for Cooperative Research in Biosciences (CIC bioGUNE), has shown that the metabolic profile of an organism indicates its level of cellular ageing and the general state of health in mice. These results could be of great use for preventive molecular medicine, given that they would indicate the state of health quickly and in a non-invasive manner, and that they would help to prevent illnesses or to diagnose them at the earliest stages.

The metabolism is one of the processes which best defines the general state of organisms. With the aim of studying a possible relationship between the metabolism and ageing, the authors of this study have used a new methodology that, based on liquid chromatography techniques and nuclear magnetic resonance, has made it possible to study up to 1.500 metabolitesintermediate products of the metabolismin 130 mice using very small samples just 5-10 l of blood serum.

"Using this new technique, we have seen that the metabolic profile of mice depends on their age; specifically, we have found 48 metabolites that vary very significantly with age", says CNIO researcher Bruno Bernardes de Jess, one of the study's authors.

When researchers carried out the same analysis in mice that had increased levels of telomerase those that age more slowly, according to a study published recently by the Blasco laboratory in the journal EMBO Molecular Medicine, they observed that the metabolic footprint was very similar to that of the youngest mice. When they studied mice with telomerase deficiencies those that aged more quickly, they observed a metabolic profile very similar to that of older animals.

Recent studies in humans indicate a possible relationship between the metabolism and life expectancy. "Our large-scale analysis, that analyses a larger amount of metabolites than has ever been studied before, validates the theory that the metabolome faithfully shows cells' biological clocks", says Mato.

NEW BIOMARKERS TO EVALUATE THE STATE OF HEALTH

Ageing is characterised in large part by metabolic decline that implies loss of hepatic, renal, coronary or cardiac function, as well as an increased risk of suffering cancer. In fact, some of the 48 metabolites identified in the study have previously been related to illnesses associated with age, such as Alzheimer's or cardiovascular diseases.

The results of this research may be useful for predicting the overall state of health in humans, via the extraction of a small blood sample. They might also be useful for preventing illnesses related to the passage of time, which make up the majority of deadly diseases in developed countries.

From these results, the researchers are also looking into searching for diagnostic biomarkers that are associated to high-impact socioeconomic illnesses such as diabetes, obesity or cardiovascular diseases.


'/>"/>
Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

Related medicine news :

1. Metabolic protein launches sugar feast that nurtures brain tumors
2. New technology for a more efficient treatment of Pompe disease and other metabolic disorders
3. Moffitt Cancer Center researchers identify novel metabolic programs driving aggressive brain tumors
4. Metabolic syndrome makes a difference in hormone therapy risk
5. In obesity, a micro-RNA causes metabolic problems
6. Obese people can be metabolically healthy and in good shape
7. Study links breast cancer risk to early-life diet and metabolic syndrome
8. Metabolic engineer synthesizes key breast milk ingredient, makes research possible
9. Obesity and metabolic syndrome associated with impaired brain function in adolescents
10. New research uncovers diverse metabolic roles for PML tumor suppressor gene
11. Ancestral link places Mexican-Americans at greater risk for metabolic disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery ... of Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , ... for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey ...
(Date:6/25/2016)... Oklahoma (PRWEB) , ... June 25, 2016 , ... ... both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures ... Oklahoma City area —Johnson is one of the first doctors to perform the ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort ... holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain ... Disease (SCD) is a disorder of the red blood cells, which can cause episodes ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Comfort Keepers® ... American Cancer Society and the Road To Recovery® program to drive cancer patients to ... and other adults to ensure the highest quality of life and ongoing independence. ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... client, The Grove Investment Group (TGIG), has initiated cultivation and processing operations at ... Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a complete ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... SAN FRANCISCO, Calif. , June 24, 2016 ... GBT ), a biopharmaceutical company developing novel therapeutics ... significant unmet needs, today announced the closing of ... shares of common stock, at the public offering ... shares in the offering were offered by GBT. ...
(Date:6/24/2016)... BEIJING , June 24, 2016 Dehaier ... or the "Company"), which develops, markets and sells medical ... China , signed a strategic cooperation agreement with ... as "Hongyuan Supply Chain") on June 20, 2016, to ... Under the strategic cooperation agreement, Dehaier will leverage Hongyuan ...
(Date:6/24/2016)... Belgium , June 24, 2016 /PRNewswire/ ... announced the appointment of Dr. Edward Futcher ... a Non-Executive Director, effective June 23, 2016.Dr. Futcher ... and Nominations and Governance Committees.  As a non-executive ... provide independent expertise and strategic counsel to VolitionRx ...
Breaking Medicine Technology: