Navigation Links
Metabolic Syndrome Triggered by Overeating, Not Obesity

Mouse study concludes weight gain is an early symptom, not a direct cause

FRIDAY, April 18 (HealthDay News) -- Overeating, not the obesity it causes, is the actual cause of metabolic syndrome, suggests a study with mice by researchers at the University of Texas Southwestern Medical Center at Dallas.

Metabolic syndrome is a collection of health factors that increase the risk of developing insulin resistance, fatty liver, heart disease and type 2 diabetes.

This study was among the first to propose that weight gain is an early symptom, not a direct cause, of metabolic syndrome, the researchers said.

"Most people today think that obesity itself causes metabolic syndrome," senior author Dr. Roger Unger, professor of internal medicine, said in a prepared statement. "We're ingrained to think obesity is the cause of all health problems, when, in fact, it is the spillover of fat into organs other than fat cells that damages these organs, such as the heart and the liver. Depositing fatty molecules in fat cells where they belong actually delays that harmful spillover."

In this study, Under and his colleagues compared normal mice to mice that were genetically altered to prevent their fat cells from expanding. Both groups of mice were overfed.

The normal mice got fat but didn't develop signs of metabolic syndrome until after about seven weeks of overeating. The genetically altered mice stayed slim but became seriously ill within a few weeks and displayed evidence of severe heart problems and major increases in blood sugar levels eight weeks before minimal heart problems developed in the normal mice, the researchers said.

The genetically altered mice showed significant damage to heart cells and to the insulin-secreting cells in the pancreas. They also got sick quicker, because the extra calories they consumed weren't stored in fat cells, but rather in other tissues, the researchers said.

The study was published online in the journal Proceedings of the National Academy of Sciences.

The exact cause of metabolic syndrome, which affects about 50 million Americans, is unknown, but lack of exercise and obesity have been tagged as the primary underlying contributors to the development of the condition, according to background information in the study.

More information

The U.S. National Heart, Lung, and Blood Institute has more about metabolic syndrome.

-- Robert Preidt

SOURCE: University of Texas Southwestern Medical Center at Dallas, news release, April 16, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. AUDIO from Medialink and Apple Products Research and Education Council: New Research -- Adults Who Eat Apples, Apple Juice Have Healthier Diets and Lower Risk for Metabolic Syndrome
2. Adults who eat apples, drink apple juice have lower risk for metabolic syndrome
3. Vaccine Induced Inflammation Linked to Epidemic of Type 2 Diabetes and Metabolic Syndrome
4. Normal weight obesity: An emerging risk factor for heart and metabolic problems
5. Metabolic Cardiologist Offers New Hope for Women With Heart Disease
6. University of Pittsburgh researchers crack code of 3-D structure in key metabolic protein
7. Exercise and caloric restriction may be treatment method for metabolic syndrome
8. Diuretics excel in drug comparison trial involving hypertension/metabolic syndrome
9. Diuretics Best for Hypertension and Metabolic Syndrome
10. Metabolic syndrome affects nearly 1 in 10 US teens
11. Burgers, fries, diet soda: Metabolic syndrome blue-plate special
Post Your Comments:
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... ... solution provider of IBM software products, introduced a new company, RightSensor™ LLC, an ... and data communications capability. RightSensor™ provides a fully-managed approach for customers requiring ...
(Date:10/13/2015)... ... 13, 2015 , ... Dr. Poneh Ghasri, dentist in West Hollywood , ... The research, which was conducted at the Dental Institute at King's College London in ... stress during pregnancy and future dental health in the child. For years, researchers have ...
(Date:10/13/2015)... ... October 13, 2015 , ... A child without a healthy mouth is ... the leading remote invisible aligner system, has joined with Global Dental Relief ... For each aligner treatment plan purchased, SmileCareClub will donate one clinic visit to a ...
(Date:10/13/2015)... Hills, CA (PRWEB) , ... October 13, 2015 ... ... management and workflow solutions, announced today their Title Sponsorship of Synergy 2015. The ... in Henderson, NV at Green Valley Ranch and will unite customers, partners, WennSoft ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... Illinois with more than 59,000 emergency department visits per year, today announced the ... T-System, to help improve clinical, operational and financial outcomes. , In ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... 2015  Kay Elledge, M.D., an established South ... of Obstetrics and Gynecology (FACOG) for the past ... Genuine Self Medical Laser Center where she provides ... of Breast Cancer Awareness Month , the ... MonaLisa Touch treatments initiated in the month ...
(Date:10/13/2015)... 13, 2015  Human Longevity, Inc. (HLI), the genomics-based, ... announced today the launch of the company,s first Health ... the potential to transform healthcare. The inaugural Health Nucleus ... , at HLI,s headquarters facility. More Health Nucleus facilities ... and International cities. --> ...
(Date:10/13/2015)... SAN DIEGO , Oct. 13, 2015 /PRNewswire/ ... bioelectronics for use in research and diagnostics, announces ... of $1.6 million led by Serra Ventures. ... Nanomed,s mission is providing low-cost, easy-to-use monitoring and ... personal health decisions. The funding round will enable ...
Breaking Medicine Technology: