Navigation Links
Metabolic Syndrome Triggered by Overeating, Not Obesity
Date:4/18/2008

Mouse study concludes weight gain is an early symptom, not a direct cause

FRIDAY, April 18 (HealthDay News) -- Overeating, not the obesity it causes, is the actual cause of metabolic syndrome, suggests a study with mice by researchers at the University of Texas Southwestern Medical Center at Dallas.

Metabolic syndrome is a collection of health factors that increase the risk of developing insulin resistance, fatty liver, heart disease and type 2 diabetes.

This study was among the first to propose that weight gain is an early symptom, not a direct cause, of metabolic syndrome, the researchers said.

"Most people today think that obesity itself causes metabolic syndrome," senior author Dr. Roger Unger, professor of internal medicine, said in a prepared statement. "We're ingrained to think obesity is the cause of all health problems, when, in fact, it is the spillover of fat into organs other than fat cells that damages these organs, such as the heart and the liver. Depositing fatty molecules in fat cells where they belong actually delays that harmful spillover."

In this study, Under and his colleagues compared normal mice to mice that were genetically altered to prevent their fat cells from expanding. Both groups of mice were overfed.

The normal mice got fat but didn't develop signs of metabolic syndrome until after about seven weeks of overeating. The genetically altered mice stayed slim but became seriously ill within a few weeks and displayed evidence of severe heart problems and major increases in blood sugar levels eight weeks before minimal heart problems developed in the normal mice, the researchers said.

The genetically altered mice showed significant damage to heart cells and to the insulin-secreting cells in the pancreas. They also got sick quicker, because the extra calories they consumed weren't stored in fat cells, but rather in other tissues, the researchers said.

The study was published online in the journal Proceedings of the National Academy of Sciences.

The exact cause of metabolic syndrome, which affects about 50 million Americans, is unknown, but lack of exercise and obesity have been tagged as the primary underlying contributors to the development of the condition, according to background information in the study.

More information

The U.S. National Heart, Lung, and Blood Institute has more about metabolic syndrome.



-- Robert Preidt



SOURCE: University of Texas Southwestern Medical Center at Dallas, news release, April 16, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. AUDIO from Medialink and Apple Products Research and Education Council: New Research -- Adults Who Eat Apples, Apple Juice Have Healthier Diets and Lower Risk for Metabolic Syndrome
2. Adults who eat apples, drink apple juice have lower risk for metabolic syndrome
3. Vaccine Induced Inflammation Linked to Epidemic of Type 2 Diabetes and Metabolic Syndrome
4. Normal weight obesity: An emerging risk factor for heart and metabolic problems
5. Metabolic Cardiologist Offers New Hope for Women With Heart Disease
6. University of Pittsburgh researchers crack code of 3-D structure in key metabolic protein
7. Exercise and caloric restriction may be treatment method for metabolic syndrome
8. Diuretics excel in drug comparison trial involving hypertension/metabolic syndrome
9. Diuretics Best for Hypertension and Metabolic Syndrome
10. Metabolic syndrome affects nearly 1 in 10 US teens
11. Burgers, fries, diet soda: Metabolic syndrome blue-plate special
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Many families ... However, many long-term care insurance companies have a waiver for care if the client ... elimination period, when the family pays for care, is often waived, so the benefits ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network for ... for action towards gender equality at their inaugural Summit in New York City in ... reached a social audience of over 3 million. To watch the Mobilize Women video, ...
(Date:10/13/2017)... Texas (PRWEB) , ... October 13, 2017 , ... Yisrayl ... this week that explains one of the most popular and least understood books in ... like cryptic and puzzling descriptions that have baffled scholars for centuries. Many have tossed ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a ... has been awarded a contract by the Center for Medicare and Medicaid Services ... accelerate the enterprise use of Agile methodologies in a consistent and high value ...
(Date:10/13/2017)... ... 2017 , ... “America On The Brink”: the Christian history of the United ... the creation of published author, William Nowers. Captain Nowers and his wife, Millie, ... spent thirty years in the Navy. Following his career as a naval aviator ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... , Oct. 10, 2017  NDS received FDA 510(k) clearance in ... medical-grade battery-powered display stand specifically designed for endoscopy environments. An innovative ... into a clinical solution to support the improvement of patient outcomes, ... Design ... Solution ...
(Date:10/4/2017)... Korea , Oct. 4, 2017  South Korean-based ... next-generation CPR training aide "cprCUBE" on Kickstarter. The device ... compression during cardiac arrests with better efficiency compared to ... also offers real-time feedback on efficacy of the compression ... crowdfunding campaign has a goal to raise $5,000. ...
(Date:10/2/2017)... , Oct. 2, 2017  Eli Lilly and ... financial results for the third quarter of 2017 on ... conference call on that day with the investment community ... The conference call will begin at 9 ... can access a live webcast of the conference call ...
Breaking Medicine Technology: