Navigation Links
Metabolic Syndrome Triggered by Overeating, Not Obesity
Date:4/18/2008

Mouse study concludes weight gain is an early symptom, not a direct cause

FRIDAY, April 18 (HealthDay News) -- Overeating, not the obesity it causes, is the actual cause of metabolic syndrome, suggests a study with mice by researchers at the University of Texas Southwestern Medical Center at Dallas.

Metabolic syndrome is a collection of health factors that increase the risk of developing insulin resistance, fatty liver, heart disease and type 2 diabetes.

This study was among the first to propose that weight gain is an early symptom, not a direct cause, of metabolic syndrome, the researchers said.

"Most people today think that obesity itself causes metabolic syndrome," senior author Dr. Roger Unger, professor of internal medicine, said in a prepared statement. "We're ingrained to think obesity is the cause of all health problems, when, in fact, it is the spillover of fat into organs other than fat cells that damages these organs, such as the heart and the liver. Depositing fatty molecules in fat cells where they belong actually delays that harmful spillover."

In this study, Under and his colleagues compared normal mice to mice that were genetically altered to prevent their fat cells from expanding. Both groups of mice were overfed.

The normal mice got fat but didn't develop signs of metabolic syndrome until after about seven weeks of overeating. The genetically altered mice stayed slim but became seriously ill within a few weeks and displayed evidence of severe heart problems and major increases in blood sugar levels eight weeks before minimal heart problems developed in the normal mice, the researchers said.

The genetically altered mice showed significant damage to heart cells and to the insulin-secreting cells in the pancreas. They also got sick quicker, because the extra calories they consumed weren't stored in fat cells, but rather in other tissues, the researchers said.

The study was published online in the journal Proceedings of the National Academy of Sciences.

The exact cause of metabolic syndrome, which affects about 50 million Americans, is unknown, but lack of exercise and obesity have been tagged as the primary underlying contributors to the development of the condition, according to background information in the study.

More information

The U.S. National Heart, Lung, and Blood Institute has more about metabolic syndrome.



-- Robert Preidt



SOURCE: University of Texas Southwestern Medical Center at Dallas, news release, April 16, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. AUDIO from Medialink and Apple Products Research and Education Council: New Research -- Adults Who Eat Apples, Apple Juice Have Healthier Diets and Lower Risk for Metabolic Syndrome
2. Adults who eat apples, drink apple juice have lower risk for metabolic syndrome
3. Vaccine Induced Inflammation Linked to Epidemic of Type 2 Diabetes and Metabolic Syndrome
4. Normal weight obesity: An emerging risk factor for heart and metabolic problems
5. Metabolic Cardiologist Offers New Hope for Women With Heart Disease
6. University of Pittsburgh researchers crack code of 3-D structure in key metabolic protein
7. Exercise and caloric restriction may be treatment method for metabolic syndrome
8. Diuretics excel in drug comparison trial involving hypertension/metabolic syndrome
9. Diuretics Best for Hypertension and Metabolic Syndrome
10. Metabolic syndrome affects nearly 1 in 10 US teens
11. Burgers, fries, diet soda: Metabolic syndrome blue-plate special
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... , ... February 10, 2016 ... ... – 1 UNF Drive, Jacksonville, FL 32224, February 26th: Amateur & Professional ... Elite Division - Time: 7:00pm – 10:00pm | Ticket Prices $30, Social ...
(Date:2/10/2016)... ... February 09, 2016 , ... A new leadership team ... 2016. FHU President Joe Wiley made the announcement Monday night, Feb. 8, prior to ... 2003 graduate of FHU and the creator of GO! Camp, has been named director. ...
(Date:2/10/2016)... ... February 10, 2016 , ... It’s that time of ... the new president of the Interscholastic Athletic Association of Maryland (IAAM), Hall of Fame ... quickly fitness goals are cast aside. , That’s why one of her first decisions ...
(Date:2/9/2016)... ... February 09, 2016 , ... URise Products announces today an ... the StandUp Walker. Made entirely in the USA, the StandUp Walker is one ... StandUp Walker’s novel patent-pending design offers 2-in-1 benefits of a stand-assist device ...
(Date:2/9/2016)... ... February 09, 2016 , ... Establishment Labs, a global breast implant ... to the company´s Board of Directors. , “We are honored to welcome ... exceptional entrepreneur.” said Juan Jose Chacon Quiros, CEO of Establishment Labs. "David’s knowledge and ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... February 9, 2016 QGEN ... collaboration with 10x Genomics to develop and promote ... and bioinformatics. --> QGEN ; Frankfurt ... 10x Genomics to develop and promote comprehensive solutions ... --> QIAGEN N.V. (NASDAQ: QGEN ...
(Date:2/9/2016)... LONDON , Feb. 9, 2016 The new report ... Acuity Business Research & Consulting group reveals that global diagnostic ultrasound ... expected to grow to US$ 7,466.3 million by 2019 at a ... market analysis of global ultrasound market has been analyzed for six ... , Asia-Pacific , Latin America ...
(Date:2/9/2016)... LONDON , Feb. 9, 2016 This ... surgical interventions, reported by the ICD-9 coding system in ... to the surgical procedure volumes, the report provides written ... and dynamics of the local markets. In addition, the latest ... --> --> The ...
Breaking Medicine Technology: