Navigation Links
Mesothelioma drug slows disease progression in patients with an inactive NF2 gene
Date:11/8/2012

Preliminary findings from the first trial of a new drug for patients with mesothelioma show that it has some success in preventing the spread of the deadly disease in patients lacking an active tumour suppressor gene called NF2. The study is presented at the 24th EORTC-NCI-AACR [1] Symposium on Molecular Targets and Cancer Therapeutics in Dublin, Ireland, today (Friday) [2].

Mesothelioma, which is usually caused by exposure to asbestos, has few treatment options and patients usually die within 9-17 months of diagnosis. Previous research has shown that the gene NF2, which produces a protein called merlin, is frequently inactivated in approximately 50% of mesotheliomas. Merlin negatively regulates another protein called focal adhesion kinase (FAK) in mesothelioma, and so when NF2 and merlin are inactivated, the activity of FAK is increased and mesothelioma cells become invasive and start to spread. When NF2 and merlin activity is restored, FAK activity and cell invasion are decreased.

Professor Jean-Charles Soria, Professor of Medicine and Medical Oncology at South Paris University and head of early drug development at the Institut Gustave Roussy in Paris (France), said: "This suggested that if we could inhibit FAK in mesothelioma patients, it might slow or stop the spread of the disease. Pre-clinical work has shown that an agent, currently known as GSK2256098, is a potent and specific inhibitor of FAK. Early in the clinical study presented today, a patient with mesothelioma, who had progressed quickly on prior therapies, had prolonged stable disease while on GSK2256098, which is suggestive of clinical activity."

Prof Soria and colleagues at nine centres in France, Australia and the United Kingdom recruited 29 mesothelioma patients to the phase I study of GSK2256098, starting in July 2010. The study is continuing.

The mesothelioma patients took the drug orally in capsule form twice a day at doses ranging from 300 - 1500 mg, wi
'/>"/>

Contact: Emma Mason
wordmason@mac.com
ECCO-the European CanCer Organisation
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study pinpoints malignant mesothelioma patients likely to benefit from drug pemetrexed
2. Mesothelioma Victims Center Now Urges US Navy Veterans Or Individuals With Mesothelioma To Call Them For The Names Of The Best Mesothelioma Attorneys & Treatment Options
3. The Mesothelioma Victims Center Now Offers The Names Of the Best Mesothelioma Attorneys To Senior Citizens Diagnosed With Mesothelioma Because They Have Rights Too
4. Mesothelioma Victims Center Urges US Navy Veterans or Anyone with Mesothelioma to Call Them for the Names of the Best Mesothelioma Attorneys in the US-Quality Matters
5. Mesothelioma Victims Center Now Offers Its Services to Chemical Plant or Power Plant Workers Living with Mesothelioma Including Naming the Best Mesothelioma Attorneys
6. Mesothelioma Victims Center Now Offers All Families Dealing With A Mesothelioma Diagnosis The Names Of The Best Mesothelioma Attorneys-No Other Group Offers this Service
7. Mesothelioma Victims Center Now Offers A US Navy Veteran Individual Or Family Dealing With Mesothelioma The Names Of The Best Mesothelioma Attorneys--Quality Matters
8. The Mesothelioma Victims Center's Unsurpassed Mesothelioma Victim's Initiative Now Includes Naming The Best Mesothelioma Attorneys Or Mesothelioma Law Firms In The US
9. Mild HIV type slows development of AIDS and makes new preventive treatments possible
10. Infection With 2 HIV Strains Slows Disease Progression
11. Oxygen Therapy Slows Type 1 Diabetes in Mice, Study Says
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... 2014 Sometimes you have to lose the life ... book “From Zero to a Hundred: Finding My Purpose through My ... of surviving a broken family, a childhood of gang violence and ... you were created to be,” Roy said. “I didn’t give up ... know my purpose today of helping others overcome their trials.” , ...
(Date:8/21/2014)... Michael E. Steuer , local doctor in Memphis, TN, ... City with recent philanthropy at local synagogue. “The state of ... says friend and Rabbi David Julian of Or Chadash in ... in-house for the needy and teaching Hebrew to students, Steuer ... synagogue. And to remain close with the development of Israel, ...
(Date:8/21/2014)... Phoenix, AZ (PRWEB) August 21, 2014 ... Foundation have donated $10,000 to support ovarian cancer research, ... , Cundiff, who is also the kicker for the ... Kicking Cancer Event was matched by Colleen’s Dream Foundation ... Goodheart, MD, an Assistant Professor in the Division of ...
(Date:8/21/2014)... 2014 Recently, BambooIndustry.com, one of the ... added a new range of hand scraped bamboo ... has launched an Autumn special offer for these elegant ... can get a discounted price, up to 25% off; ... 05. , Providing natural looks and available in ...
(Date:8/20/2014)... 2014 Most people think of donating ... often get overlooked for a variety of reasons—thus making ... pantries. Understanding this need, Dr. Bryne Willey of ... health care center, wanted to heighten awareness of the ... first annual Thanksgiving in July food drive to collect ...
Breaking Medicine News(10 mins):Health News:Zero to a Hundred: True Story of Escaping Death to Meet Life 2Health News:Drake University’s Phi Gamma Delta (FIJI) and Colleen’s Dream Foundation Donate $10,000 to the University of Iowa’s Holden Cancer Center to Fight Ovarian Cancer 2Health News:Drake University’s Phi Gamma Delta (FIJI) and Colleen’s Dream Foundation Donate $10,000 to the University of Iowa’s Holden Cancer Center to Fight Ovarian Cancer 3Health News:Cheap Hand Scraped Bamboo Floorings Recently Unveiled by BambooIndustry.com 2Health News:AlignLife Springfield Office Donates 565 Canned Goods to Springfield Food Pantry 2
... , , ARLINGTON, Va., Jan. 8 Health ... virtually the entire field of health care law. That is ... Health Law Reporter advisory board, in a survey conducted ... , The majority of survey respondents applauded reform,s major ...
... booth sensors, researchers say , FRIDAY, Jan. 8 (HealthDay ... and Drug Administration and pacemaker manufacturers confirms that emissions ... can interfere with pacemakers, although that risk is small. ... in store security tags, hotel room keycards, automated toll ...
... , , SAN FRANCISCO, Jan. 8 Gloria ... announced that she will retire near the end of ... Directors of her decision in September 2009 to allow ... next CEO. , (Photo: http://www.newscom.com/cgi-bin/prnh/20100108/SF34303 ...
... HILLS, Calif., Jan. 8 Providence Holy Cross Medical ... a $500,000 grant from Verizon, that will improve the ... health care outreach for uninsured Californians. , The two-year ... arm of Verizon Communications -- was announced Friday (Jan. ...
... , , , , MINNEAPOLIS, Jan. 8 ... Courage Award . Since 1980, Minnesota-based Courage Center ... contributions to the health, welfare and rehabilitation of people with ... Max Cleland, Justin Dart Jr., Sen. Bob Dole, Rep. Jim ...
... Jan. 8 Cephalon, Inc. (Nasdaq: CEPH ) has scheduled its regular quarterly ... EST on Thursday, February 11, 2010. , February 11, 2010 Schedule ... 2009 results will be distributed by PRNewswire, 4:50 p.m. EST ... and refer ...
Cached Medicine News:Health News:Restructuring, Consolidation in Health Care Make Reform Top Health Law Issue for 2010 2Health News:Common Radio Frequency Tag Readers Might Trouble Pacemakers 2Health News:Gloria Austin, Brown & Toland's Chief Executive Officer, Announces Retirement 2Health News:Gloria Austin, Brown & Toland's Chief Executive Officer, Announces Retirement 3Health News:Providence Holy Cross Medical Center Upgrades Technology to Increase Health Care Efficiency, Thanks to $500,000 Verizon Grant 2Health News:Providence Holy Cross Medical Center Upgrades Technology to Increase Health Care Efficiency, Thanks to $500,000 Verizon Grant 3Health News:Courage Center Seeks Nominations for 2010 National Courage Award 2Health News:Cephalon Fourth Quarter & Full Year 2009 Earnings Conference Call Thursday, February 11, 2010 at 5:00 p.m. EST 2
(Date:8/20/2014)... YORK , Aug. 20, 2014 /PRNewswire/ ... research report is available in its catalogue: ... Market for Bluetooth, RFID, Zigbee, UWB WWAN, ... http://www.reportlinker.com/p0652514/Wireless-Opportunities-in-Healthcare-The-Market-for-Bluetooth-RFID-Zigbee-UWB-WWAN-WMAN-WLAN-and-other-technologies.html Kalorama ... for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, ...
(Date:8/20/2014)... and PHOENIX , Aug. ... to bring cutting-edge next-generation sequencing and proteomic diagnostics ... today announced a collaboration with TESARO, Inc.  Paradigm ... patient tissue samples from clinical trials to better ... to TESARO,s TSR-011.  This may lead to more successful ...
(Date:8/20/2014)... , Aug. 20, 2014 Reportlinker.com announces ... in its catalogue: The Market for ... The European, Middle Eastern and African ... devices. As part of its coverage, this study: ... on the EMEA medical device markets and estimates ...
Breaking Medicine Technology:Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 2Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 3Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 4Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 5Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 6Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 7Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 8Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 9Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 10Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 11Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 12Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 13Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 14Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 15Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 16Paradigm Announces Molecular Profiling Collaboration with TESARO, Inc. 2The Market for Medical Devices in EMEA 2The Market for Medical Devices in EMEA 3The Market for Medical Devices in EMEA 4The Market for Medical Devices in EMEA 5
... Oct. 12 Today at the annual AdvaMed ... provider of Good Promotional Practices software, announced a ... hotline and case management solutions. Together, the companies ... to help Life Sciences companies cope with the ...
... Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX ) today announced that ... general business update on Monday, October 12, 2009, at 8:00 ... parties may access a live webcast of the presentation on ... or by dialing 847-413-3362 and using the passcode 25577870#. ...
Cached Medicine Technology:Prolifiq and EthicsPoint Announce Partnership: 'Automatic Alerts' Help Life Sciences Engage in Good Promotional Practices 2Prolifiq and EthicsPoint Announce Partnership: 'Automatic Alerts' Help Life Sciences Engage in Good Promotional Practices 3
... pessary is designed for third ... well as a cystocele and ... available both with and without ... silicone tie to aid in ...
The Incontinence Dish is used to relieve stress incontinence and minor degrees of prolapse. The Incontinence Dish comes with and without support. It is available in eight different sizes....
The Shaatz pessary, available in nine sizes, is used for a first to second degree prolapse and an accompanying cystocele....
... are among the smallest and ... with advanced reporting software that ... information. Extensive testing by independent ... accuracy, making it widely recognized ...
Medicine Products: