Navigation Links
Mersana's Second Development Candidate, XMT-1107, Shows Superior Pharmacokinetics and Anti-Tumor Activity in Studies Presented at American Association of Cancer Research Meeting
Date:4/19/2009

- Data Show Fleximer(R) Extends Exposure to Conjugated Drug -

CAMBRIDGE, Mass., April 19 /PRNewswire/ -- Mersana, a platform-based cancer therapeutics company, today announced positive results of preclinical studies for its second development candidate, XMT-1107, in two posters at the 2009 Annual Meeting of the American Association of Cancer Research (AACR) in Denver.

The studies showed that XMT-1107, a novel anti-angiogenic fumagillin analog conjugated to Mersana's proprietary Fleximer(R), demonstrated superior anti-tumor activity in tumor xenograft models in comparison to other anti-angiogenic agents and extended exposure to the conjugated drug, supporting the potential clinical utility of XMT-1107 as an anti-cancer agent. Full text of the abstracts can be viewed online at the AACR website at www.AACR.org.

"We're encouraged by the ongoing progress we're seeing with XMT-1107, which targets a novel mechanism to inhibit endothelial cell proliferation and has the potential to target a wide variety of angiogenic tumors," said Julie Olson, Mersana CEO. "Earlier drugs in this class showed promising activity in the clinic but were discontinued due to reversible neurological toxicity. Conjugation of our novel fumagillin 'warhead' to Fleximer using a specific linker technology reduces CNS exposure in animal models to below detection limits. We look forward to advancing XMT-1107 into clinical studies by early 2010."

"Anti-angiogenic and anti-tumor activity of XMT-1107, a fumagillin-derived polymer conjugate, and its in vivo release product XMT-1191"

By Laura C. Akullian, Cheri A. Stevenson, John Benson, Robert J. Fram, Timothy B. Lowinger

This study showed that XMT-1107 has enhanced anti-angiogenic and anti-tumor activity compared to small molecule analogs delivered without the benefit of Fleximer.
'/>"/>

SOURCE Mersana Therapeutics, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Secondhand Smoke Quickly Affects Blood Vessels
2. Every 30 Seconds an African Child Dies from Malaria; Education Key to Prevention
3. Rochester Medical Announces Second Quarter 2009 Earnings Conference Call April 30, 2009
4. Valensa Completes Second Expansion of Astaxanthin Capacity
5. Success of Colorful School Supply Collection Inspired by Leukemia Patient Kicks off Second Year
6. Metro Parents Second Annual Living With Autism Workshop Features Local Experts Who Are Intimately Involved in Improving the Lives of These Special Children
7. Equinox Fitness Clubs Continues National Expansion with the Opening of its Second Boston Location
8. Second European Radiosurgery Workshop Yields Record Attendance
9. Secondhand Smoke Affecting Millions of New Yorkers
10. Hillenbrand Expects to Report Second-Quarter Net Revenue of $170.8 Million and Revises 2009 Guidance
11. MoleSafe USA Opens Second Location in Albuquerque, New Mexico
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2014)... treat children with uncomplicated acute appendicitis is a reasonable ... fewer missed school days, according to a pilot study. ... Hospital and published online April 12 in the ... the first prospective study on nonoperative management of acute ... , Researchers enrolled 77 patients age 7 to 17 ...
(Date:4/14/2014)... 2014, Perth, Australia. Drug discovery company Proteomics International ... of a companion diagnostic (CDx) test with the ... The research team authenticated the panel of biomarkers ... samples. Seven biomarkers were validated at high stringency ... The mass spectrometry data was then cross-validated using ...
(Date:4/14/2014)... 2014) When it comes to the cost and ... Patients get the best care when they are treated ... extensive experience in their current job, according to a ... and Columbia Business School. The study was published in ... Applied Economics . , The review of more ...
(Date:4/13/2014)... STANFORD, Calif. A low-cost empowerment program for ... and sexual harassment of these girls, who live ... and are frequently attacked, a large new study ... Stanford University School of Medicine, Lucile Packard Children,s ... No Worldwide, validated the program,s effectiveness in combating ...
(Date:4/11/2014)... the processes that control brain cell production could pave ... brain-related disorders. , Scientists have gained new understanding of ... how and when nerve and brain cells are formed ... and keeps it healthy. Their findings could help explain ... which is a fundamental characteristic of many diseases including ...
Breaking Medicine News(10 mins):Health News:Antibiotics alone are a successful treatment for uncomplicated acute appendicitis in kids 2Health News:Antibiotics alone are a successful treatment for uncomplicated acute appendicitis in kids 3Health News:Longer nurse tenure on hospital units leads to higher quality care 2Health News:Empowerment program greatly decreases incidence of rape, Stanford/Packard-led study finds 2Health News:Empowerment program greatly decreases incidence of rape, Stanford/Packard-led study finds 3Health News:Empowerment program greatly decreases incidence of rape, Stanford/Packard-led study finds 4
... WASHINGTON, May 12 A new report from ... medications for a variety of diseases often are ... and Asian Americans. This comprehensive review of studies ... Origins and Strategies for Addressing Ethnic and ...
... the personal injury attorney firm in Manhattan, is standing up against insurance ... ... 2009 -- New York personal injury lawyers can have a ... business. When it comes to frivolous lawsuits, these monsters want the public ...
... President of CanReg Inc., is pleased to announce that ... Executive Advisory Strategist to assist client firms with their ... with small to medium sized public and private biotechnology ... been on directing and managing regulatory affairs, most recently ...
... other strains of influenza, CDC says , , TUESDAY, May 12 ... seeing some complications among pregnant women as the swine flu ... at higher risk of complications of influenza, whether it,s the ... seeing some severe complications in women with this year,s novel ...
... The Pennsylvania Department of Aging and the Office of ... Council that will advise on new policies and procedures to ... citizens and those with disabilities prefer to live independently and ... so we want to make sure that the services we ...
... (Nasdaq: VOLC ), a leader in the ... and treatment of coronary and peripheral artery disease, said ... Annual JMP Securities Research Conference on Monday, May 18.The ... at 3:00 p.m., Pacific Daylight Time (6:00 p.m., Eastern ...
Cached Medicine News:Health News:Report Reveals Disparities in Pharmaceutical Treatment for Minority Patients 2Health News:Report Reveals Disparities in Pharmaceutical Treatment for Minority Patients 3Health News:Report Reveals Disparities in Pharmaceutical Treatment for Minority Patients 4Health News:Manhattan Personal Injury Attorney Blames Insurance Industry For Negative Perception Of Civil Justice System 2Health News:Swine Flu May Pose Problems for Pregnant Women 2Health News:Swine Flu May Pose Problems for Pregnant Women 3Health News:Swine Flu May Pose Problems for Pregnant Women 4Health News:Swine Flu May Pose Problems for Pregnant Women 5Health News:Swine Flu May Pose Problems for Pregnant Women 6Health News:Swine Flu May Pose Problems for Pregnant Women 7Health News:Swine Flu May Pose Problems for Pregnant Women 8Health News:Swine Flu May Pose Problems for Pregnant Women 9Health News:Pennsylvania Council Formed to Advise on Improving Services to Older Adults, People with Disabilities 2Health News:Volcano Corporation Presentation at JMP Conference to be Webcast 2
(Date:1/14/2014)... Mass. , Jan. 14, 2014 ... HTWR ), a leading innovator of less invasive, ... treatment of advanced heart failure, today announced that ... 2013 will be approximately $53 million, bringing expected ... "Our full-year revenue growth of 87% for ...
(Date:1/14/2014)... Jan. 14, 2014 InformEx, North ... and sellers of high-value chemistry, will hold the 30 ... Miami Beach Convention Center from ... More than 3,500 attendees from top pharmaceutical, ... in the conference, which includes on-site education sessions, daily ...
(Date:1/14/2014)... Pa. , Jan. 14, 2014 Dynamic Healthcare ... ("GMH"), announced today that it acquired Progressive Home Medical Equipment, ... January 7, 2014. The terms of the acquisition were not ... medical equipment ("DME") company providing a wide range of sleep, ... Pennsylvania and Pittsburgh ...
Breaking Medicine Technology:HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 2HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 3HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 4Media Advisory: InformEx 2014 Events & Speaker Lineup for 30th Edition Conference in Miami Beach 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 3
... Inc. is pleased to introduce the GlideScope(®) Cobalt AVL, ... DVD clarity, enabling quick intubation. The new single ... camera, offers integrated real-time recording as well as advanced ... addition to the GlideScope(®) brand also provides a unique ...
... , STAMFORD, Conn., Oct. 15 AmeriCares has awarded ... one of the largest health care products and services ... Welling presented the award today at the Healthcare Distribution ... , The Power of Partnership Award was created by ...
Cached Medicine Technology:Verathon Introduces the GlideScope(R) Cobalt Advanced Video Laryngoscope (AVL); New Digital Technology Facilitates Quick Intubations 2AmeriCares Honors Cardinal Health with Power of Partnership Award 2AmeriCares Honors Cardinal Health with Power of Partnership Award 3
Empore Sealing Tape Pads are ideal for covering a 96 well plate during storage or transfer to another work station. Not intended for use with auto-injectors....
Mylar Plate Sealers 100/Box...
TD silicone foam compression pad. Use with plates sealed with TDX or OptiTape....
For use with 96-well plates, catalog # 410150...
Medicine Products: