Navigation Links
Mersana's Second Development Candidate, XMT-1107, Shows Superior Pharmacokinetics and Anti-Tumor Activity in Studies Presented at American Association of Cancer Research Meeting
Date:4/19/2009

- Data Show Fleximer(R) Extends Exposure to Conjugated Drug -

CAMBRIDGE, Mass., April 19 /PRNewswire/ -- Mersana, a platform-based cancer therapeutics company, today announced positive results of preclinical studies for its second development candidate, XMT-1107, in two posters at the 2009 Annual Meeting of the American Association of Cancer Research (AACR) in Denver.

The studies showed that XMT-1107, a novel anti-angiogenic fumagillin analog conjugated to Mersana's proprietary Fleximer(R), demonstrated superior anti-tumor activity in tumor xenograft models in comparison to other anti-angiogenic agents and extended exposure to the conjugated drug, supporting the potential clinical utility of XMT-1107 as an anti-cancer agent. Full text of the abstracts can be viewed online at the AACR website at www.AACR.org.

"We're encouraged by the ongoing progress we're seeing with XMT-1107, which targets a novel mechanism to inhibit endothelial cell proliferation and has the potential to target a wide variety of angiogenic tumors," said Julie Olson, Mersana CEO. "Earlier drugs in this class showed promising activity in the clinic but were discontinued due to reversible neurological toxicity. Conjugation of our novel fumagillin 'warhead' to Fleximer using a specific linker technology reduces CNS exposure in animal models to below detection limits. We look forward to advancing XMT-1107 into clinical studies by early 2010."

"Anti-angiogenic and anti-tumor activity of XMT-1107, a fumagillin-derived polymer conjugate, and its in vivo release product XMT-1191"

By Laura C. Akullian, Cheri A. Stevenson, John Benson, Robert J. Fram, Timothy B. Lowinger

This study showed that XMT-1107 has enhanced anti-angiogenic and anti-tumor activity compared to small molecule analogs delivered without the benefit of Fleximer.
'/>"/>

SOURCE Mersana Therapeutics, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Secondhand Smoke Quickly Affects Blood Vessels
2. Every 30 Seconds an African Child Dies from Malaria; Education Key to Prevention
3. Rochester Medical Announces Second Quarter 2009 Earnings Conference Call April 30, 2009
4. Valensa Completes Second Expansion of Astaxanthin Capacity
5. Success of Colorful School Supply Collection Inspired by Leukemia Patient Kicks off Second Year
6. Metro Parents Second Annual Living With Autism Workshop Features Local Experts Who Are Intimately Involved in Improving the Lives of These Special Children
7. Equinox Fitness Clubs Continues National Expansion with the Opening of its Second Boston Location
8. Second European Radiosurgery Workshop Yields Record Attendance
9. Secondhand Smoke Affecting Millions of New Yorkers
10. Hillenbrand Expects to Report Second-Quarter Net Revenue of $170.8 Million and Revises 2009 Guidance
11. MoleSafe USA Opens Second Location in Albuquerque, New Mexico
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/21/2014)... (PRWEB) December 21, 2014 Over the ... performance issues in hundreds of emergency departments across the ... Its findings have been translated into an innovative suite ... to correct deficiencies and enhance the patient experience. ... emergency physician staffing and management services for hospitals, announced ...
(Date:12/21/2014)... Theme and plugin developers ... plugin for Final Cut Pro X entitled ProMotion. , ... more with absolute ease.” Said Christiana Austin, CEO of ... needed to easily animate their media inside FCPX.” , ... users to animate pictures, videos, logos, and more with ...
(Date:12/21/2014)... CannabisClassifieds.com celebrates marijuana’s new legal place at the table ... kind, the site has provided its faithful users with everything ... It uniquely combines the benefits of platforms like Craigslist, ... the masses. Assuring the potent herb’s followers it’s well ... approval. , Shane Chattin, Owner of Cannabis Classifieds ...
(Date:12/21/2014)... Concept Plus, LLC. a SDB and 8(a) certified ... today announced it has been recognized by Washington Technology ... the fastest growing government contracting small businesses by calculating their ... is the first year that Concept Plus, LLC., participated in ... 95.92% compound annual growth rate. “For Concept Plus to be ...
(Date:12/20/2014)... 21, 2014 BambooIndustry.com is ... the business has announced its bamboo flooring promotion ... best material from certified suppliers, and offers the ... worldwide. In the current promotion, all customers can ... when they say they know BambooIndustry.com from press ...
Breaking Medicine News(10 mins):Health News:NES Health Launches Stipend Program for Emergency Physicians in Training to Financially Assist Emergency Department Doctors While They Learn 2Health News:Announcing a new plugin for Final Cut Pro X ProMotion from Pixel Film Studios. 2Health News:CannabisClassifieds.com Maintains its “Craigslist for Cannabis” Standing with Website Re-launch 2Health News:Concept Plus, LLC. Named One of Washington Technology’s Fast 50 2Health News:Eco-friendy Bamboo Flooring Manufacturer BambooIndustry.com Introduces Its Bamboo Flooring Promotion for 2015 2
... study from the University of Michigan Comprehensive Cancer Center ... prognosis and are 35 percent more likely to doe ... cancer and found that blacks with advanced cancer had ... it. ,Results of the study appear in the ...
... Heart, Lung and Blood Institute (NHLBI) Working Group finds ... treating depression// in their patients, they are more likely ... The report is published in "Annals of Behavioral Medicine" ... to 20 percent of patients with heart disease meet ...
... this week’s British Medical Journal, the doctors must contemplate ... Richard Lehman writes that this matter in spite of ... national level in the profession. ,Over the ... centralising services, and many local campaigns over individual threatened ...
... protein molecules called enzymes catalyze specific biochemical reactions in ... or structure play a major role in enzyme catalysis. ... energy landscape" of the enzyme that directs it to ... of the energetic barriers to these catalytic changes. The ...
... the August issue of the American Journal of Roentgenology ... tomography (MDCT) in diagnosing// the spread of breast cancer. ... 69 patients to examine the efficiency of both tests. ... 44 cases, while MDCT correctly diagnosed 27. "MRI revealed ...
... issued a warning that drugs used to treat attention ... psychiatric side-effects that could manifest as agitation and even ... rare incidences of side-effects, that all drugs used to ... warnings, by the beginning of December. , ,Canadian ...
Cached Medicine News:Health News:Bladder Cancer Has Worse Outcomes In Blacks 2Health News:Cardiologists Ignoring Treatment Of Depression 2Health News:Deliberation on hospital closures 2Health News:"Dynamic Energy Landscape" of enzyme in Catalysis 2
(Date:12/19/2014)... BOCA RATON, Fla. , Dec. 19, 2014 /PRNewswire/ ... entered into a multi-product agreement with MSN Laboratories Pvt. ... Breckenridge and MSN expect to commercialize several new ANDAs. ... manufacture, and supply the products exclusively to Breckenridge for ... the products under its label.  Breckenridge and MSN have ...
(Date:12/19/2014)... HILL, N.C. , Dec. 19, 2014 /PRNewswire/ ... to optimize a product,s web presence to reflect ... Brand websites, in particular, must meet the needs ... regulations and culture. According to ... more than half of the participating companies averaged ...
(Date:12/19/2014)... 2014  Monarch America Inc. (OTCQB: CANK) ("Monarch America" ... to provide this review of the Company,s recent achievements ... "Over this past year, we achieved many of ... proud to say that Monarch America is in a ... ever been," stated Eric Hagen , CEO of ...
Breaking Medicine Technology:Breckenridge Pharmaceutical signs Multi-Product Generic Agreement with MSN Laboratories Pvt. Ltd. 2Building a Best-in-Class Pharma Global Brand Website 2Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 2Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 3
... 14, 2011  Heska Corporation (NASDAQ: HSKA ; ... and specialty products to veterinarians, announced today the intent ... expertise in blood-related disorders.  The parties are to explore ... cell-based therapeutics, for use in the veterinary market.      ...
... Group, Inc. (OTCMARKETS: UYMG) "UNITY" (or the "Company"), and its ... it has sold its initial PZ Uno Tablet press to ... the company is not able to disclose the name of ... tablet press would be used for a research and development ...
Cached Medicine Technology:Heska Announces Exploration of New Technologies Through Strategic Collaboration with Entegrion, Inc. 2Heska Announces Exploration of New Technologies Through Strategic Collaboration with Entegrion, Inc. 3Unity Management Group, Inc. Announces Its Initial Sale of the PZ UNO Tablet Press to a Major Pharmaceutical Company for $500,000 2
Inquire...
... Subcutaneous Lead System Model 6996 ... the use of the Medtronic ... SQ design and implant technique ... and easy procedure, and high ...
... Spiral HP catheters feature 20 bipolar-spaced ... the highest degree of mapping resolution ... mapping via a 20-pole catheter enables ... potentials than with 10-pole catheter systems. ...
The Verity ADx pacemaker family, which includes the world's longest lasting single- and dual-chamber pacemakers, provides clinicians with a variety of feature options and header configurations to mee...
Medicine Products: