Navigation Links
Merlin protein found to control liver stem cells, prevent tumor development
Date:8/12/2010

ceptors. One of these is the epidermal growth factor receptor (EGFR), and oversignaling by that protein is known to lead to several types of cancer. The current study was designed to investigate the role of NF2 and merlin in the fetal and adult mouse liver, including possible involvement with tumor development.

The researchers found that infant mice lacking functioning NF2 in their livers developed dramatic overgrowth of liver stem cells, to the point of crowding out hepatocytes. Mice that did not die from a lack of functioning liver cells soon developed the two major types of liver cancer, and the fact that stem cell overgrowth preceded tumor development strongly suggested that the undifferentiated progenitors were the source of the tumors. Blocking the expression of NF2 in the livers of adult mice had minimal effect on the animals unless a portion of the liver was surgically removed, setting off the regeneration process and leading to the same stem cell overproliferation and tumor development.

McClatchey explains that the study's findings provide new information about liver stem cells and how their proliferation is controlled; identifies a new animal model for liver cancer, the lack of which has seriously impeded understanding the disease; and suggests that liver tumors may originate from liver stem cells and that excess EGFR signaling leads to liver tumor development. "These results are consistent with our previous studies showing that merlin helps to regulate EGFR activity at the cell membrance," she says. "We also showed that merlin's role in cell-to-cell communication is essential for cells to stop growing when they fill the appropriate space. Since liver progenitors need to be poised to regenerate in case of injury, they may be particularly sensitive to the loss of merlin's regulatory function." McClatchey is an associate professor of Pathology at Harvard Medical School.


'/>"/>

Contact: Katie Marquedant
kmarquedant@partners.org
617-726-0337
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New and Delicious, Almond Butter Filled, Cookie Bites With 35.7% Protein to Help Manage Weight and Build Muscle
2. Research highlights role of protein pair in obesity regulation
3. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
4. Smithfield, United Food and Commercial Workers Union, and Food Networks Paula Deen to Deliver 150,000 Servings of Protein to San Francisco Food Bank
5. Protein Sciences Corporation Announces Profitable and Cash Flow Positive Results for 2009 and Management Realignment
6. Protein Appears Key to Intestinal Balance
7. SIBLING proteins may predict oral cancer
8. Damaged protein identified as early diagnostic biomarker for Alzheimers disease in healthy adults
9. Cells of aggressive leukemia hijack normal protein to grow
10. Omega Protein Comments on California Lawsuit Alleging Fish Oil Contaminants
11. Proteins May Predict Spread of Colon Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... October 22, 2014 Hay House is pleased ... Addiction and Upgrade Your Life (Paperback; $10.82) written by the ... & Recovery. This book is meant to help readers ... life of recovery. , Recovery 2.0 is not the ... Recovery 2.0 is a guide for what comes next. ...
(Date:10/22/2014)... 22, 2014 Healthcare professionals who ... continuing education at home or on-the-go via laptops, ... 20 brand new, premium Seminar-on-Demand CE courses. The ... over 2,000 hours of CE course ... educational experience. With such a diverse library, there’s ...
(Date:10/22/2014)... 2014 Richard Carlson, Managing Partner of ... with over 25 years experience. Mr. Carlson is ... areas related to EDI, B2B Commerce, RFID and Internet/Intranet ... Advisory Board member for Pharmaceutical Commerce Magazine and a ... Group is a management and technology consulting firm focused ...
(Date:10/22/2014)... sisters in high school have developed ways to measure ... use electronic stethoscopes, which electronically amplify body sounds, to ... heartbeats. Ilina, a senior at Port Huron Northern ... to detect early lung damage in people exposed to ... one breath cycle each from 16 smokers, 25 nonsmokers ...
(Date:10/22/2014)... HealthDay Reporter , MONDAY, Oct. 20, 2014 (HealthDay ... for health workers treating Ebola patients, now requiring full body ... at all times. The U.S. Centers for Disease Control ... Dallas nurses contracted Ebola while caring for the first ... Duncan. Nina Pham is currently being treated for her infection ...
Breaking Medicine News(10 mins):Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 2Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 3Health News:Top Provider of Continuing Education at Home Releases 20 New Online Courses 2Health News:Rich Carlson and Marc Duey to Hold Workshop at CBI’s Specialty Pharmacy and Distribution Networks Conference 2Health News:Teen Sisters Develop Ways to Measure Lung, Heart Damage 2Health News:CDC Tightens Rules on Caring for Ebola Patients 2Health News:CDC Tightens Rules on Caring for Ebola Patients 3
... by the Food & Drug Administration for the treatment of prostate ... A new study shows abiraterone acetate extends the lives of ... four months. The study in the May 26, 2011 issue of ... Thomas W. Flaig, MD, medical oncologist at the University of Colorado ...
... Calif. A woman,s risk of developing diabetes during pregnancy ... pregnant based on routinely assessed measures of blood sugar and ... the online issue of the American Journal of Obstetrics ... Kaiser Permanente Division of Research in Oakland, Calif., studied 580 ...
... traumatic stress with war-afflicted populations (veterans and civilians) and ... research professor in the department of psychology and the ... the University of Houston (UH), decided to study another ... eighth grade. "Teaching is a highly stressful ...
... , WEDNESDAY, May 25 (HealthDay News) -- Taken in ... the cholesterol-lowering medication Pravachol, appear to significantly raise blood ... is most apparent -- and concerning -- among diabetics, ... noted. "This interaction may affect as many as ...
... field, poised to take a crucial penalty kick, "I always had a ... do" says sports psychologist Antonis Hatzigeorgiadis. "I was setting the ball and ... of shots; then I had that thought striking me that it was ... he recalls, "and I did miss." Even then, he could see that ...
... Medications are the mainstay of treatment for epilepsy, but for ... many as 1 million in the U.S. drugs don,t ... as refractory or drug-resistant epilepsy, in which drugs can,t control ... last month, Dr. Christopher DeGiorgio, a UCLA professor of neurology, ...
Cached Medicine News:Health News:New drug treatment extends lives of men with prostate cancer 2Health News:Diabetes can be predicted 7 years before pregnancy with blood sugar and body weight 2Health News:New University of Houston research study links job stress in teachers to student achievement 2Health News:New University of Houston research study links job stress in teachers to student achievement 3Health News:Combo of Paxil, Pravachol May Raise Blood Sugar 2Health News:Combo of Paxil, Pravachol May Raise Blood Sugar 3Health News:Thoughts that win 2Health News:Unique nerve-stimulation treatment proves effective against drug-resistant epilepsy 2
(Date:10/22/2014)...  Cephasonics, a technology-innovation leader with a game-changing embedded-ultrasound ... Ultrasound Box™-1), the first product in a new family ... Cephasonics for purchase by companies to rebrand with their ... showcasing the cQUB-1 for the first time at CMEF ... Chongqing, China from October 23 to 26. ...
(Date:10/22/2014)... , Oct. 22, 2014  Charlene Vernak, RPh, of Vernak ... , recently was awarded the George Roentsch Scholarship by ... the award in Houston during ... is awarded annually to an independent pharmacist and PCCA ... George Roentsch , a well-known pharmacist in the ...
(Date:10/22/2014)... October 22, 2014 A new ... Market (Product type, Form, End user, Application and Geography) ... Analysis, Research, Report, Opportunities, Segmentation and Forecast, 2013 - ... market. Based on key trends tracked, it is anticipated ... $7.9 billion by 2020, registering a CAGR of 6.2% ...
Breaking Medicine Technology:Cephasonics Launches the cQUB-1, First Product in New Family of cQUB White-Label Ultrasound Systems Targeted at Medical Applications 2Cephasonics Launches the cQUB-1, First Product in New Family of cQUB White-Label Ultrasound Systems Targeted at Medical Applications 3PCCA Awards Charlene Vernak, RPh, the George Roentsch Scholarship 2Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 2Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 3Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 4
... Manzanita Senior Center today aims to inform older adults about ... plays in helping to improve the body,s immune response against ... typically the hardest hit by influenza, according to the U.S. ... launching in the Phoenix area today, called Influenza Immunization ...
... In today,s quality-driven healthcare environment, oncologists balance a ... the ongoing business success of their practice. Today, ... McKesson Corporation , announced that through its ... offering Innovative Practice Services to help oncology practices ...
Cached Medicine Technology:Influenza Awareness Initiative for Phoenix Seniors Highlights Need for Influenza Vaccination for Adults Age 65 and Older 2New McKesson Specialty Health Program Helps Providers Thrive In Today's Quality-Driven Healthcare Environment 2New McKesson Specialty Health Program Helps Providers Thrive In Today's Quality-Driven Healthcare Environment 3
The Optima III line of laparoscopic hand instruments provides a well-crafted set of instruments designed for strength and durability....
The Optima III line of laparoscopic hand instruments provides a well-crafted set of instruments designed for strength and durability....
The Optima III line of laparoscopic hand instruments provides a well-crafted set of instruments designed for strength and durability....
Inquire...
Medicine Products: