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Merck's odanacatib increased BMD over 2 years at key fracture sites in Phase IIB study
Date:9/16/2008

ne by 13.26 percent (p=0.002) and sP1NP was reduced by 20.20 percent from baseline (p=0.011). s-BSAP and sP1NP changes for placebo were increases of 3.38 percent and 1.29 percent respectively.

Safety results with odanacatib

The number of patients experiencing a drug-related adverse experience was similar between the 50 mg odanacatib group and placebo (34.6 percent and 39.8 percent respectively). Likewise, the discontinuation rates due to drug-related adverse experiences were similar between the 50 mg odanacatib group and placebo (7.7 percent and 4.8 percent respectively). For the 50 mg odanacatib group, the most common drug-related adverse experiences, as assessed by investigators, were nausea, headache, rash and muscle spasms. There was no dose-dependent increase in the incidence of skin adverse experiences or upper respiratory tract infections observed through 24 months.

Phase III study underway

The effect of odanacatib 50 mg on vertebral, hip and non-vertebral fractures is currently being evaluated in a large, global Phase III study.


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Contact: Ron Rogers
908-423-6449
Merck & Co., Inc.
Source:Eurekalert

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