Navigation Links
Merck's odanacatib increased BMD over 2 years at key fracture sites in Phase IIB study
Date:9/16/2008

umbar spine. Secondary endpoints included the LS mean change from baseline in BMD at the total hip, femoral neck, hip trochanter, and distal forearm, and changes in bone turnover based on biochemical markers.

"Bone mineral density" or BMD is the amount of mineralized bone tissue in a certain volume of bone and is one non-invasive measure used to help determine a patient's fracture risk. Odanacatib increased BMD

In the study, once-weekly treatment with 10, 25 and 50 mg of odanacatib significantly increased BMD at the lumbar spine, total hip and femoral neck at 24 months compared to baseline values. The 50 mg dose (n=58) resulted in LS mean percent increases in BMD of

5.48 percent at the lumbar spine compared to baseline values while treatment with placebo (n=61) resulted in a decrease of 0.19 percent compared to baseline (p=0.001). Similarly, the 50 mg dose resulted in LS mean percent increases in BMD of 3.16 percent at the total hip and 3.84 percent at the femoral neck compared to baseline values while treatment with placebo resulted in decreases of 0.93 percent and 0.85 percent respectively compared to baseline (p=0.001). Treatment with 3 mg odanacatib resulted in decreases in BMD at the lumbar spine, total hip and femoral neck. Changes in bone resorption and bone formation

The study also assessed biochemical markers of bone resorption including sCTx (serum C-terminal telopeptides of Type 1 collagen) and uNTx (urinary N-telopeptides/creatinine ratio). Treatment with 50 mg of odanacatib resulted in decreases from baseline of 51.83 percent in uNTx and 30.57 percent in sCTx (p=0.001). sCTx and uNTx changes for placebo were an increase of 32.77 percent and a decrease of 4.62 percent respectively.

Treatment with the 50 mg dose reduced biochemical markers of new bone formation including s-BSAP (bone specific alkaline phosphatase) and sP1NP (serum N-terminal propeptides of type 1 collagen). s-BSAP was reduced from baseli
'/>"/>

Contact: Ron Rogers
908-423-6449
Merck & Co., Inc.
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Cord Blood America CEO Announces Aggressive Acquisition Strategy, Increased Investor Relations Efforts, New Stem Cell Storage Models
2. Army personnel show increased risk for migraine
3. Physician Recruiting Standard Reveals Larger Populations Experiencing Increased Doctor Shortage
4. Celsius Holdings Reports Increased Revenue 2nd Quarter Revenue Increased 166%
5. Average Annual Medical Premium Costs Increased 6%, Says 2008 Benefit Plan Report from C&B Consulting
6. Social Security Attorneys Prepare for Increased Baby Boomer SSI Claims
7. Sleep apnea linked to increased risk of death
8. Drinking in excess associated with increased risk for metabolic syndrome
9. New study finds smoking predicts increased stroke risk for your spouse
10. Grupo Casa Saba Announces Sales and Operating Income Increased 14.05% and 13.45%, Respectively
11. Responding to Increased Incidence of Obesity and Associated Health Issues, The HealthCentral Network Launches Site to Support those Struggling with Weight
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... ... July 31, 2015 , ... Recently ... know in predictive health analytics , Jvion continues to disrupt the predictive ... predictive software that targets patient and population level illness to drive prevention and ...
(Date:7/31/2015)... GA (PRWEB) , ... July 31, 2015 , ... Sculpted ... , the CoolSmooth PRO this week. Zeltiq Aesthetics released this new applicator in ... in January 2014 for treating the outer thighs. The original applicator required a ...
(Date:7/31/2015)... Meadows, IL (PRWEB) , ... July 31, 2015 ... ... ways to communicate. Rally Insurance Group, Inc. has re-branded their social media profiles ... provides a personal way for consumers to communicate, find information, share insights and ...
(Date:7/31/2015)... ... July 31, 2015 , ... Ticket Down is a reliable source of ... catch a new and refreshing show on Broadway, look no further than Hamilton. This ... Obie Award, Outer Critics Circle Award, Drama Desk Award, Lucille Lortel Award, and New ...
(Date:7/31/2015)... ... July 31, 2015 , ... Well-known for its unique pastries and ... cakes with custom designs, making life just a little bit sweeter for newlyweds. ... for each customer who orders one. , The bakery provides a full line of ...
Breaking Medicine News(10 mins):Health News:Jvion Showcased as Leader in the Predictive Analytic Market 2Health News:Cooler Coolsculpting in Atlanta: Treatments Now Twice As Fast 2Health News:Cooler Coolsculpting in Atlanta: Treatments Now Twice As Fast 3Health News:Rally Insurance Group, Inc. Connects to Customers Through Re-branded Social Media Profiles 2Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 2Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 3Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 4Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 5Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 6Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 7Health News:Pastry Palace of Las Vegas Announces It Is Now Offering Custom Wedding Cakes in Las Vegas 2
... Dairy Daily, SACRAMENTO, Calif., March 11 Reducing ... as drinking low-fat milk with meals,according to new research., ... or more daily servings,of low-fat dairy products were 11 ... the Brigham and Women,s Hospital in Boston,attributed the benefit ...
... AARP Services Inc. and,Genworth Financial, Inc. (NYSE: ... a,new long term care insurance plan for AARP,s ... affordable alternative to traditional,long term care insurance and ... with more states anticipated., (Logo: http://www.newscom.com/cgi-bin/prnh/20070209/NYF043LOGO ...
... Emory University School of Medicine and Children,s Healthcare of ... California to find new ways to make kidney transplants ... will partner with UCLA,s Mattel Childrens Hospital in Los ... Palo Alto for a study of kidney transplants in ...
... release is available in German . , ... themselves by programmed cell death, or apoptosis. Therefore, tumors ... effect is based on forcing tumor cells to commit ... by defects in one of the numerous molecular switches ...
... Down Boundaries That Can Limit Treatment Options ... for Older Colorectal Cancer Patients, ... announce today the 2008 award recipients of the,Breaking Boundaries program, ... down the boundaries that can limit appropriate treatment,of older colorectal ...
... a healthier start to life through ... running and physical fitness, ATLANTA, March 11 ... of running shoes and orange,shoelaces on Sunday, March 30 as he partners ... during the 2008 ING,Georgia Marathon and Half Marathon., Brooking, who plays ...
Cached Medicine News:Health News:Low-Fat Dairy Reduces High Blood Pressure Risk 2Health News:AARP Services Inc. and Genworth Financial Introduce New Innovative and Affordable Long Term Care Insurance Option to AARP Members 2Health News:AARP Services Inc. and Genworth Financial Introduce New Innovative and Affordable Long Term Care Insurance Option to AARP Members 3Health News:AARP Services Inc. and Genworth Financial Introduce New Innovative and Affordable Long Term Care Insurance Option to AARP Members 4Health News:NIH grant to Emory and pediatric partners aims to improve kidney transplants for children 2Health News:Paradigm shift: Switch for programmed cell death promotes spread of glioblastoma 2Health News:Breaking Boundaries Program Honors Colorectal Cancer Survivors for Outstanding Leadership Achievements 2Health News:Breaking Boundaries Program Honors Colorectal Cancer Survivors for Outstanding Leadership Achievements 3Health News:Breaking Boundaries Program Honors Colorectal Cancer Survivors for Outstanding Leadership Achievements 4Health News:Atlanta Falcons Linebacker Keith Brooking Prepares to 'Run for Something Better' at ING Georgia Marathon 2Health News:Atlanta Falcons Linebacker Keith Brooking Prepares to 'Run for Something Better' at ING Georgia Marathon 3Health News:Atlanta Falcons Linebacker Keith Brooking Prepares to 'Run for Something Better' at ING Georgia Marathon 4Health News:Atlanta Falcons Linebacker Keith Brooking Prepares to 'Run for Something Better' at ING Georgia Marathon 5
(Date:7/31/2015)... WOODCLIFF LAKE, N.J. and SAN ... announced today that its parent company Eisai Co., Ltd. ... Haruo Naito , "Eisai") and Halozyme Therapeutics, Inc. ... and CEO: Dr. Helen Torley , "NASDAQ: HALO") ... eribulin mesylate (brand name: Halaven ® , "eribulin") in ...
(Date:7/30/2015)... 30, 2015 Mettler-Toledo International Inc. (NYSE: ... Provided below are the highlights: , Sales ... with the prior year. Reported sales decreased 4% as ... , Net earnings per diluted share as reported ... period. Adjusted EPS was $2.80 , an increase ...
(Date:7/30/2015)... IRVINE, Calif. , July 30, 2015 /PRNewswire/ ... Novartis /Alcon executives have recently contacted the Company ... will begin as early as Monday, August 3, ... been quoted as saying that the coming electronic ... billions of dollars over the next several years.  ...
Breaking Medicine Technology:Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 2Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 3Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 4Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 5Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 6Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 2Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 3Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 4Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 5Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 6Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 7Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 8Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 9Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 10Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 11Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 12Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 13Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 14
... in lupus research was met this weekend!  On Saturday, October 22 ... annual New York City Walk with Us to Cure Lupus ... enthusiasm of the nearly 3000 walkers in attendance to walk for ... My9 news anchor Brenda Blackmon, ALR Chairman Robert Wood Johnson IV, ...
... 2011 Connectyx (Other OTC:  CTYX) - Connectyx ... that the Company will be hosting a nationwide ... EST, to discuss the company,s third quarter financials, ... advertising campaigns encompassing their health and wellness program ...
Cached Medicine Technology:Alliance for Lupus NYC Walk With Us to Cure Lupus First Lupus Walk In History To Raise $1-Million 2Connectyx Technologies to Host Teleconference on Third Quarter Financial Results on Tuesday November 15, 2011 2Connectyx Technologies to Host Teleconference on Third Quarter Financial Results on Tuesday November 15, 2011 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: