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Mental vulnerability associated with increased risk of cardiovascular disease
Date:4/17/2013

, smoking, systolic blood pressure and total cholesterol).

During the follow-up period there were 3045 fatal and non-fatal cardiovascular events recorded in the study population of 10,943 subjects. When the statistical analysis was performed, results showed that mental vulnerability was significantly associated with fatal and non-fatal cardiovascular events independently of the classical risk factors; the risk of events in the mentally vulnerable was 36% higher than in the non-vulnerable (hazard ratio 1.366; 1.208 - 1.545).

Are the findings sufficiently robust to suggest that mental vulnerability is considered an independent marker of cardiovascular disease - and as such able to improve the precision of risk prediction? "Several studies have found risk factors for cardiovascular disease which are clearly independent but within a broader context contribute little if anything to actual risk prediction," explains Dr Borglykke. "One of the reasons for this is that the impact of the well established risk factors - age, sex, smoking, blood pressure and total cholesterol - tend to dominate the risk stratification models. This means that a risk factor such as our scale of mental vulnerability clearly increases the risk significantly - by 36% - but still does not improve risk prediction in the general population."

Statistical analysis in this study showed that adding mental vulnerability to a risk stratification model which included the principal risk factors resulted in only very small changes in discriminative ability.

"However," added Dr Borglykke, "these results do not necessarily mean that we should ignore mental vulnerability in our assessment of individual risk. It is still possible that it might improve risk prediction - or even emerge as a new marker to explain or reclassify some cardiovascular cases which cannot be attributed to classical risk factors.

"So mental vulnerability might describe a 'new dimension' when compa
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Contact: Jacqueline Partarrieu
press@escardio.org
33-492-947-756
European Society of Cardiology
Source:Eurekalert

Page: 1 2 3

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