Navigation Links
Mental and physical exercise delays dementia in fatal genetic disease
Date:1/24/2008

Scientists at Melbournes Howard Florey Institute have discovered that mental and physical stimulation delays the onset of dementia in the fatal genetic disease, Huntington's disease.

This Australian research opens up new therapeutic possibilities for other devastating and difficult to treat brain diseases, including Alzheimers disease where dementia is a key component.

The Floreys Dr Jess Nithianantharajah and Dr Anthony Hannan showed mice with the Huntingtons disease gene displayed impairments on learning and memory tests at an early stage of the disease, prior to the obvious signs of movement problems. This closely correlates with observations in Huntingtons disease patients.

However, Dr Jess Nithianantharajah said by providing the mice with an enriched environment that enhanced their mental and physical stimulation, the mice performed better on these memory tests.

This discovery is quite remarkable because we have shown that an enriched environment not only delayed the onset of dementia, but it also slowed the progression of memory loss in these mice, Dr Jess Nithianantharajah said.

We also showed that in the Huntingtons disease mice, specific molecular changes occur that relate to communication between brain cells (synapses) in a region of the brain called the hippocampus, which plays a significant role in the formation of memories.

The Huntingtons disease mice without increased mental and physical activity showed decreased levels of specific proteins that are expressed at the synapse, which are essential for normal brain function.

But the Huntingtons disease mice exposed to increased mental and physical activity did not show this decrease, she said.

Huntingtons is a very powerful model for nature-versus-nurture investigations. This discovery implies that gene-environment interactions and how they affect changes in the brains pathways is important for all brain diseases.

Treatments for complex psychiatric disorders, like depression and schizophrenia, may also benefit from these research efforts.


'/>"/>

Contact: Merrin Rafferty
merrin.rafferty@florey.edu.au
038-344-1658
Research Australia
Source:Eurekalert

Related medicine news :

1. The Willie Gary Law Firm Files $1 Billion Lawsuit Against Durham County LME, Wake County LME, Five County LME, Mecklenberg County LME and Value Options, Inc. for Negligent and Intentional Misconduct Against Mental Health Agency
2. Investigating causes of asthma attacks: New sensor system monitors environmental exposure
3. Rich nations environmental footprints tread heavily on poor countries
4. Columbia Center for Childrens Environmental Health receives NIEHS grant to study asthma
5. Treatment Advocacy Centers Top 10 Mental Illness Stories You Didnt Read in 2007
6. Mental Decline Faster in Brain-Injured Vietnam Vets
7. Mental health linked to amputation risk in diabetic veterans
8. Pittsburgh Ringing in New Year with Environmentally Friendly Ball
9. Treatment Advocacy Center Honors Three Grassroots Mental Illness Advocates
10. Is there a developmental component to the risk for depression?
11. Environmental Toxin Collects in Breast Milk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... ... 2017 , ... Bacteria and fungi are probably not the first ingredients that come to mind ... right microorganisms in your diet can actually improve health outcomes. And the good news is ... topic of a new peer-reviewed paper led by Maria Marco, Ph.D. , ...
(Date:3/27/2017)... ... March 27, 2017 , ... The respected dental ... want straight teeth without the extensive time commitment and aesthetic disadvantages of traditional ... a referral. A custom-designed series of virtually invisible aligners are created for each ...
(Date:3/27/2017)... Ohio (PRWEB) , ... March 27, 2017 , ... New ... OH to replace their missing teeth can now have them placed by Dr. Manju ... the latest i-CAT® Cone Beam technology to increase the accuracy of each dental implant ...
(Date:3/27/2017)... ... March 27, 2017 , ... ... gain site attention and engagement over the household brands of Top-20 pharma by ... will discuss how partnering with the right outsourcing payments provider can provide the ...
(Date:3/27/2017)... ... March 27, 2017 , ... A study by the founder of the ... Sudeep Roy, MD, was recently published in the American Journal of Cosmetic Surgery. ... Drs. Buckingham and Roy’s study on the use of Electro Lube during the facelift ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... 2017 To mark the end of Save Your ... leader in digital imaging solutions, will showcase Canon eye care ... New York,s Jacob Javits Center from ... sponsored by the American Optometric Association, is observed annually in ... comprehensive eye exams. In recognition of this observance, Canon ...
(Date:3/27/2017)... -- A new survey from the American Association ... Program (CBP) significantly reduced beneficiary choice and access to ... forces beneficiaries to switch to unfamiliar or unsuitable testing ... AADE,s survey is the latest in a continuous ... the inherent problems with the CBP. Last year, a ...
(Date:3/27/2017)... YORK , March 27, 2017 FinancialBuzz.com ... Based ... adult use in states where cannabis is legal will generate $655 ... million will be from cannabis specific taxes, such as ... $96 million will be earned from state sales taxes that are ...
Breaking Medicine Technology: