Navigation Links
Mental and physical exercise delays dementia in fatal genetic disease
Date:1/24/2008

Scientists at Melbournes Howard Florey Institute have discovered that mental and physical stimulation delays the onset of dementia in the fatal genetic disease, Huntington's disease.

This Australian research opens up new therapeutic possibilities for other devastating and difficult to treat brain diseases, including Alzheimers disease where dementia is a key component.

The Floreys Dr Jess Nithianantharajah and Dr Anthony Hannan showed mice with the Huntingtons disease gene displayed impairments on learning and memory tests at an early stage of the disease, prior to the obvious signs of movement problems. This closely correlates with observations in Huntingtons disease patients.

However, Dr Jess Nithianantharajah said by providing the mice with an enriched environment that enhanced their mental and physical stimulation, the mice performed better on these memory tests.

This discovery is quite remarkable because we have shown that an enriched environment not only delayed the onset of dementia, but it also slowed the progression of memory loss in these mice, Dr Jess Nithianantharajah said.

We also showed that in the Huntingtons disease mice, specific molecular changes occur that relate to communication between brain cells (synapses) in a region of the brain called the hippocampus, which plays a significant role in the formation of memories.

The Huntingtons disease mice without increased mental and physical activity showed decreased levels of specific proteins that are expressed at the synapse, which are essential for normal brain function.

But the Huntingtons disease mice exposed to increased mental and physical activity did not show this decrease, she said.

Huntingtons is a very powerful model for nature-versus-nurture investigations. This discovery implies that gene-environment interactions and how they affect changes in the brains pathways is important for all brain diseases.

Treatments for complex psychiatric disorders, like depression and schizophrenia, may also benefit from these research efforts.


'/>"/>

Contact: Merrin Rafferty
merrin.rafferty@florey.edu.au
038-344-1658
Research Australia
Source:Eurekalert

Related medicine news :

1. The Willie Gary Law Firm Files $1 Billion Lawsuit Against Durham County LME, Wake County LME, Five County LME, Mecklenberg County LME and Value Options, Inc. for Negligent and Intentional Misconduct Against Mental Health Agency
2. Investigating causes of asthma attacks: New sensor system monitors environmental exposure
3. Rich nations environmental footprints tread heavily on poor countries
4. Columbia Center for Childrens Environmental Health receives NIEHS grant to study asthma
5. Treatment Advocacy Centers Top 10 Mental Illness Stories You Didnt Read in 2007
6. Mental Decline Faster in Brain-Injured Vietnam Vets
7. Mental health linked to amputation risk in diabetic veterans
8. Pittsburgh Ringing in New Year with Environmentally Friendly Ball
9. Treatment Advocacy Center Honors Three Grassroots Mental Illness Advocates
10. Is there a developmental component to the risk for depression?
11. Environmental Toxin Collects in Breast Milk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2016)... ... 06, 2016 , ... From May 4 to 6, EarQ and ... opportunity to learn more about Signia’s technology and the successful business and marketing techniques ... priority to see practices succeed in this highly competitive industry,” said Ed Keller, president ...
(Date:5/6/2016)... Arizona (PRWEB) , ... May 06, 2016 , ... ... moved domains to Sleepopolis.com . , Since launching in September, 2014 Sleepopolis ... research and testing areas, which now include pillows, sheets, mattress toppers, bed frames, ...
(Date:5/6/2016)... , ... May 06, 2016 , ... ... online provider of career-focused education and corporate training, and the National Military Family ... to announce Maritza Aquino as the second full-tuition scholarship recipient of 2016. ...
(Date:5/6/2016)... ... May 06, 2016 , ... RowdMap, Inc. ... Cross BlueShield and Former Principal Deputy Administrator at Centers for Medicare and Medicaid ... Steve Ondra, MD, Chief Medical Officer at Health Care Service Corporation (Blue Cross ...
(Date:5/5/2016)... ... May 05, 2016 , ... Qrono Inc. , ... a development collaboration with the Australian critical medicine company, Phebra Pty Ltd. ... , LAI medicines can offer improved therapeutic benefits over oral formulations, including better ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... 2016 Research and Markets has announced ... in the USA"  report to their offering.  ,     (Logo: ... the current Positron Emission Tomography (PET) scanner and cyclotron ... market. Along with the current known number of PET ... , the report also contains a detailed breakdown of ...
(Date:5/5/2016)... 5, 2016 ... of the  "Europe Thrombocytopenia Market and ... to their offering.       ... ,The latest research Europe Thrombocytopenia Market ... provides comprehensive insights into Thrombocytopenia pipeline ...
(Date:5/4/2016)... Conn., May 4, 2016  Compass Diversified Holdings (NYSE: ... "Company"), an owner of leading middle market businesses, announced ... ended March 31, 2016. First Quarter 2016 ... and Reinvestment ("CAD" or "Cash Flow") of $13.6 million ... net loss of $15.0 million for the first quarter ...
Breaking Medicine Technology: