Navigation Links
Meningitis vaccine study gets £200,000 boost
Date:2/7/2008

It can kill in four hours and more than 300 people in the UK die from it every year and hundreds more are left with permanent disabilities. Now researchers will work on a potential vaccine for meningitis B, thanks to a 200,000 grant from the medical charity Meningitis UK.

Although vaccines exist to protect against some strains of meningitis, there is still no vaccine to protect against all strains, including the most common in the UK Group B meningococci. This is responsible for almost 90 per cent of all cases and is most common in children under the age of five.

The team, led by Dr Karl Wooldridge, a lecturer in the Centre for Biomolecular Sciences, aim to develop a vaccine against this strain of the bacterium. Group B meningococci mimic molecules in the human body, which makes developing an effective vaccine against this strain very difficult.

Researchers worldwide are searching for alternative antigens molecules that can stimulate an immune response on the surface of the bacteria, which could be used as a basis for a vaccine against meningitis B.

The team has identified a series of autotransporter proteins proteins which are secreted from the surface of Group B meningococci which could be used to create antibodies that will then kill the bacteria.

The grant will be used to fund a two-year research post, examining each of the proteins produced by the bacteria for the potential to create effective antibodies. The genetic code for each protein will be cloned and tagged, allowing the protein to be produced in large amounts and purified for further study.

If we identify one or more of these proteins that give a good protective response we would ultimately move to human trials, said Dr Wooldridge. This would hopefully demonstrate a positive immune response to the vaccine. By identifying a range of active proteins, rather than just one, we could develop a vaccine that targeted all strains of the Group B meningococci.

Meningitis UK launched its Search 4 a Vaccine Campaign in 2007 to help raise 7million over the next seven years to fund vital work into developing a vaccine against Group B. This innovative project is just one of the studies the charity is funding.

Meningitis UKs Chief Executive Steve Dayman said: We are extremely pleased to be funding Dr Karl Wooldridge and his team in their work to discover more about the proteins secreted by the Meningitis B bacteria. If this research can go forward to help develop a vaccine, thousands of lives could be saved.

Meningitis can be incredibly hard to detect as many of its symptoms are often similar to more minor ailments such as the common cold or flu, plus there are occasions when people show no, or very few, symptoms. For these reasons, we believe the only way to eradicate meningitis completely is through the development of a preventative vaccine.


'/>"/>

Contact: Karl Wooldridge
karl.wooldridge@nottingham.ac.uk
University of Nottingham
Source:Eurekalert

Related medicine news :

1. Schedules Revised for Flu, Meningitis Vaccines
2. New Meningitis Vaccine Works in Infants
3. Steroid Fails to Ease Meningitis in Trials
4. Meningitis Shot Available, Effective Year-Round
5. Tattooing Best Way to Deliver DNA Vaccines
6. Novel molecules developed at UB can boost vaccine potency
7. USDA Agrees to Grant Conditional License to Bioniche for its E. coli O157:H7 Cattle Vaccine
8. Another Study Finds No Link Between MMR Vaccine and Autism
9. New hospital standards needed for pediatric flu vaccines
10. Experimental Vaccine Halts Prostate Cancer in Mice
11. Novel vaccine concept developed by scientists at the Wistar Institute
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... Caloifornia (PRWEB) , ... December 07, 2016 , ... ... present the fifth annual Business Architecture Innovation Summit in Reston, VA on March ... world who will share a range of experiences from a cross-section of industries ...
(Date:12/6/2016)... ... December 06, 2016 , ... People ... can be seen on a type of MRI, according to a study appearing ... of the central nervous system characterized by tremors or trembling and stiffness in ...
(Date:12/6/2016)... ... December 06, 2016 , ... According to a November 1 ... consuming too many mints or not drinking enough water, which can cause bad breath ... Care notes that good oral hygiene not only helps reduce the possibility of bad ...
(Date:12/6/2016)... , ... December 06, 2016 , ... Mount Sinai Health ... the Department of Neurosurgery, where clinicians can confer and order 3D models for their ... low-cost fee-for-service basis with quick turnaround times. This resource will be the first ...
(Date:12/6/2016)... , ... December 06, 2016 , ... CarriersEdge, providers of ... a new suite of Driver Wellness courses. Offered in three modules, the courses can ... point so fleets can educate drivers about how to stay healthy on the road. ...
Breaking Medicine News(10 mins):
(Date:12/6/2016)... 2016  "Blood Tests replace Surgical Biopsies. Single ... The Diagnostic, Monitoring and Screening Test opportunities are ... occurring using in vitro blood testing to identify ... backing, has announced a single blood test to ... than the market. New technology that definitively identifies ...
(Date:12/6/2016)... -- The pen needles market is projected to reach ... in 2016, growing at a CAGR of 11.2% during ... the years, the pen needles market has witnessed various ... demand for safety injections in the healthcare industry. These ... needles with an aim to reduce pain, increase comfort, ...
(Date:12/6/2016)... -- BTL Aesthetics today announced the release of a ... device was effectively redesigned for more efficient, predictable ... The result: Significantly better outcomes in abdominal fat ... versus BTL Vanquish. "We are committed ... with the most highly-advanced devices on the market," ...
Breaking Medicine Technology: