Navigation Links
Meningitis vaccine study gets £200,000 boost
Date:2/7/2008

It can kill in four hours and more than 300 people in the UK die from it every year and hundreds more are left with permanent disabilities. Now researchers will work on a potential vaccine for meningitis B, thanks to a 200,000 grant from the medical charity Meningitis UK.

Although vaccines exist to protect against some strains of meningitis, there is still no vaccine to protect against all strains, including the most common in the UK Group B meningococci. This is responsible for almost 90 per cent of all cases and is most common in children under the age of five.

The team, led by Dr Karl Wooldridge, a lecturer in the Centre for Biomolecular Sciences, aim to develop a vaccine against this strain of the bacterium. Group B meningococci mimic molecules in the human body, which makes developing an effective vaccine against this strain very difficult.

Researchers worldwide are searching for alternative antigens molecules that can stimulate an immune response on the surface of the bacteria, which could be used as a basis for a vaccine against meningitis B.

The team has identified a series of autotransporter proteins proteins which are secreted from the surface of Group B meningococci which could be used to create antibodies that will then kill the bacteria.

The grant will be used to fund a two-year research post, examining each of the proteins produced by the bacteria for the potential to create effective antibodies. The genetic code for each protein will be cloned and tagged, allowing the protein to be produced in large amounts and purified for further study.

If we identify one or more of these proteins that give a good protective response we would ultimately move to human trials, said Dr Wooldridge. This would hopefully demonstrate a positive immune response to the vaccine. By identifying a range of active proteins, rather than just one, we could develop a vaccine that targeted all strains of the Group B meningococci.

Meningitis UK launched its Search 4 a Vaccine Campaign in 2007 to help raise 7million over the next seven years to fund vital work into developing a vaccine against Group B. This innovative project is just one of the studies the charity is funding.

Meningitis UKs Chief Executive Steve Dayman said: We are extremely pleased to be funding Dr Karl Wooldridge and his team in their work to discover more about the proteins secreted by the Meningitis B bacteria. If this research can go forward to help develop a vaccine, thousands of lives could be saved.

Meningitis can be incredibly hard to detect as many of its symptoms are often similar to more minor ailments such as the common cold or flu, plus there are occasions when people show no, or very few, symptoms. For these reasons, we believe the only way to eradicate meningitis completely is through the development of a preventative vaccine.


'/>"/>

Contact: Karl Wooldridge
karl.wooldridge@nottingham.ac.uk
University of Nottingham
Source:Eurekalert

Related medicine news :

1. Schedules Revised for Flu, Meningitis Vaccines
2. New Meningitis Vaccine Works in Infants
3. Steroid Fails to Ease Meningitis in Trials
4. Meningitis Shot Available, Effective Year-Round
5. Tattooing Best Way to Deliver DNA Vaccines
6. Novel molecules developed at UB can boost vaccine potency
7. USDA Agrees to Grant Conditional License to Bioniche for its E. coli O157:H7 Cattle Vaccine
8. Another Study Finds No Link Between MMR Vaccine and Autism
9. New hospital standards needed for pediatric flu vaccines
10. Experimental Vaccine Halts Prostate Cancer in Mice
11. Novel vaccine concept developed by scientists at the Wistar Institute
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... ... January 17, 2017 , ... ... and eliminate cyber threats in real-time, today announced a strategic partnership with ... Selangor, Malaysia. Joining other Seceon partners, TechLab Security has become a strategic partner ...
(Date:1/17/2017)... ... 2017 , ... Today, FloSports , a global leader in live digital ... part of a long-term extension of their media partnership. The partnership, which began in ... the sport’s premier events exclusively on FloWrestling.com as well as usage of the FloArena ...
(Date:1/16/2017)... ... 2017 , ... Gym Source, America’s leading retailer of premium residential and commercial ... Jersey. , “We are elated to be opening this new showroom,” explains Tom Richard, ... give clients a seamless and motivating shopping experience.” , Every fitness journey is unique, ...
(Date:1/16/2017)... (PRWEB) , ... January 16, 2017 , ... ... today announced the addition of Victor Giamos, MD to their medical staff, ... and Managing Partner at North Shore Eye Care, a division of SightMD. Dr. ...
(Date:1/16/2017)... ... January 16, 2017 , ... Date aired: January 9, 2017 ... Sharon Kleyne, America’s leading water educator, researcher and advocate welcomed health activist, author, ... Sharon Kleyne Hour Power of Water, Global Climate Change and Your Health on ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... Interpace Diagnostics Group, Inc., (NASDAQ: IDXG ... tests and pathology services for evaluating risks of cancer, ... January 13, 2017 from the NASDAQ Listing Qualifications notifying ... requirement of the NASDAQ Stock Market to maintain a ... The letter noted that for the last 10 ...
(Date:1/17/2017)... Jan. 17, 2017 Tempus, a technology ... and University Hospitals Seidman Cancer Center have joined ... genomic data, advanced molecular analysis and clinical decision ... and healthcare providers. As part ... and transcriptomic sequencing and analysis for ovarian and ...
(Date:1/17/2017)... , Jan. 17, 2017  CSSi, the global ... the clinical research industry, will exhibit at the 8 ... Executives (SCOPE 2017), taking place from Tuesday, January 24 ... Miami in Miami, FL. ... proprietary technology platform, SmartStudy™ EMR, which provides a revolutionary ...
Breaking Medicine Technology: