Men who take aspirin have significantly lower ...( WASHINGTON D.C. - The use of aspirin...),Health
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Men who take aspirin have significantly lower PSA levels
Date:11/16/2008
WASHINGTON, D.C. - The use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) is significantly associated with lower PSA levels, especially among men with prostate cancer, say researchers at Vanderbilt University.
This large analysis known as the Nashville Men's Health Study included 1,277 participants referred to a urologist for a biopsy of their prostate. Approximately 46 percent of the men reported taking an NSAID, mostly aspirin (37 percent of all men). After adjusting for age, race, family prostate cancer history, obesity, and other variables that have independent effects on the size of the prostate organ, cancer risk, and PSA levels, the researchers found that aspirin use was significantly associated with lower PSA levels. PSA levels were 9 percent lower in men taking aspirin (the NSAID most commonly used) compared with men who did not use aspirin, say the researchers, who will present their findings at the American Association for Cancer Research's Seventh Annual International Conference on Frontiers in Cancer Prevention Research.
A PSA test is used widely as a method to screen men for the possibility of prostate cancer, with higher blood PSA levels suggesting a greater chance of having prostate cancer. High PSA levels can also signify benign prostatic hyperplasia (BPH), a non-cancerous enlargement of the prostate organ.
"To begin to understand how aspirin may lower PSA, we also looked at the association between NSAID use and prostate volume," said the study's lead investigator Jay H. Fowke, Ph.D., an assistant professor in medicine at Vanderbilt. "Aspirin users and men who didn't use aspirin had the same prostate volume, so I don't think aspirin was changing PSA by changing the prostate volume. It was doing something different, and that suggests a beneficial effect on cancer development."
Furthermore, "the effect of aspirin on PSA was only somewhat evident among men without prostate cancer but was
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| Contact: Jeremy Moore Jeremy.moore@aacr.org 267-646-0557 American Association for Cancer Research Source:Eurekalert |
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