Navigation Links
Men May Benefit From Osteoporosis Drug, Too: Study
Date:11/1/2012

By Steven Reinberg
HealthDay Reporter

WEDNESDAY, Oct. 31 (HealthDay News) -- Older men at risk for fractures from osteoporosis may reap the same benefit as women from bone-strengthening drugs called bisphosphonates, a new study suggests.

In this case, one such drug called zoledronic acid (Reclast) significantly reduced backbone breaks in men suffering from osteoporosis. Bisphosphonates work by building bone mass, the researchers explained.

Age-linked fracture risk doesn't disappear "just because you're a man," said Dr. Robert Recker, president of the National Osteoporosis Foundation, who had no part in the study.

"We have ignored the problem in men," he believes. "Half of women over 40 will have an osteoporotic fracture before they die and about 25 percent of men will, too, so it's a substantial problem."

However, there are ways to reduce the risk in men, just as there are in women, Recker said. "This study documents this for one of the bisphosphonates, and it's likely that all bisphosphonates are also effective in men."

The new study, which was funded by Reclast's maker, Novartis Pharma, was published in the Nov. 1 issue of the New England Journal of Medicine.

The study was led by Dr. Steven Boonen, a professor of medicine at Leuven University in Belgium. His team randomly assigned nearly 1,200 men at risk for osteoporosis to intravenous infusions of Reclast or an inactive placebo. The men ranged from 50 to 85 years of age.

Both groups also took vitamin D supplements (the vitamin is thought to be key to bone health).

Reclast was given at the start of the study and again a year later. Over two years, Boonen's group looked for fractures of the vertebrae -- the small bones that make up the backbone.

The investigators found the rate of fractures was close to 2 percent among men receiving Reclast, compared with almost 5 percent of men who were given the placebo. According to the researchers, that's a 67 percent reduction in the risk of fractures for men receiving Reclast.

In addition, compared with placebo, men receiving Reclast had fewer moderate-to-severe vertebral fractures, or other forms of fractures. These men also had higher bone mineral density -- a key measure of fracture risk.

There are some risks associated with these drugs, Recker stressed. "In rare cases there are atypical fractures of the femur," he said. "But for every one of these fractures that occurs, there are between 50 and 100 fractures prevented."

Reclast has been approved for use in cancer patients when cancer has spread to the patient's bones. The doses used in cancer patients, however, are far greater than used for patients in this study, Recker noted.

The research team wrote that, "although our findings with zoledronic acid [Reclast] do not imply that all data on drugs for osteoporosis in women can be extrapolated to men, our study should provide the confidence to proceed."

Other bisphosphonates include Actonel, Boniva, Zometa and Fosamax.

Dr. Joseph Lane is chief of the metabolic bone disease service at the Hospital for Special Surgery and a professor of orthopedic surgery at Weill Cornell Medical College in New York City. He said that, "up to this point, bisphosphonates have been approved for use in men, but they have not demonstrated fracture protection, because the numbers were too small and the fracture rates were too small."

"What's exciting about this study is it demonstrates, essentially, the same fracture protection that is seen in women," he said.

If this finding is true for Reclast, it's likely true for all bisphosphonates, Lane added. "We can now feel more comfortable because we now have very strong proof that fracture protection is provided by Reclast," he said.

According to Novartis, costs for Reclast are covered by Medicare Part B. For those not on Medicare, the cost depends on individual insurance coverage, deductibles and co-pays.

More information

There's more on osteoporosis in men at the National Osteoporosis Foundation.

SOURCES: Robert Recker, M.D., president, National Osteoporosis Foundation; Joseph Lane, M.D., chief, metabolic bone disease service, Hospital for Special Surgery, and professor, orthopedic surgery, Weill Cornell Medical College, New York City; Nov. 1, 2012, New England Journal of Medicine


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Resveratrol falls short in health benefits
2. Researchers ID potential patient population who may benefit from novel anti-platelet treatment
3. Considerably more patients may benefit from effective antidiabetic drug
4. Added benefit of Cannabis sativa for spasticity due to multiple sclerosis is not proven
5. Tafamidis: Approval denotes proven added benefit
6. Mammographys Benefits Outweigh Harms for Older Women: Study
7. First comprehensive review of European breast cancer screening programs finds benefits outweigh harm
8. With food insecurity rising in US, SNAP benefits should be left alone
9. Vanderbilt study looks at benefits of progestogens to prevent early childbirth
10. Even the very elderly and frail can benefit from exercise
11. Telaprevir: Added benefit in certain patients with hepatitis C
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Men May Benefit From Osteoporosis Drug, Too: Study
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating ... many ways they remain in the eye of the beholder, according to experts who ... of The American Journal of Managed Care. For the full issue, click here ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... was developed to enhance the health of felines. The formula is all-natural and is ... herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus ...
(Date:6/25/2016)... D.C. (PRWEB) , ... June 25, 2016 , ... ... discuss health policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, ... their work on several important health care topics including advance care planning, healthcare ...
(Date:6/25/2016)... ... 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily ... of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures ... . Simply select a ProHand generator and drag it above media or text in ...
(Date:6/25/2016)... Oklahoma City, Oklahoma (PRWEB) , ... June 25, ... ... to helping both athletes and non-athletes recover from injury. Recently, he has implemented ... for the Oklahoma City area —Johnson is one of the first doctors to ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016   Bay ... Rehabilitation Network,s Dean Center for Tick Borne ... Medicine and Rehabilitation, MIT Hacking Medicine, University of ... Innovation, today announced the five finalists of ... Lyme disease.  More than 100 scientists, clinicians, researchers, ...
(Date:6/24/2016)... , June 24, 2016 ... the "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural ... Structural electronics involves electronic and/or ... protective structures, replacing dumb structures such as vehicle ...
(Date:6/24/2016)... , June 24, 2016 Dehaier Medical Systems ... "Company"), which develops, markets and sells medical devices and ... , signed a strategic cooperation agreement with Hongyuan Supply ... Supply Chain") on June 20, 2016, to develop Dehaier,s ... strategic cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s ...
Breaking Medicine Technology: