Berkeley -- A large study of patients with mild cognitive impairment revealed that results from cognitive tests and brain scans can work as an early warning system for the subsequent development of Alzheimer's disease.
The research found that among 85 participants in the study with mild cognitive impairment, those with low scores on a memory recall test and low glucose metabolism in particular brain regions, as detected through positron emission tomography (PET), had a 15-fold greater risk of developing Alzheimer's disease within two years, compared with the others in the study.
The results, reported by researchers at the University of California, Berkeley, on Tuesday, July 14, at the Alzheimer's Association 2009 International Conference on Alzheimer's Disease in Vienna, Austria, are a major step forward in the march toward earlier diagnoses of the debilitating disease.
"Not all people with mild cognitive impairment go on to develop Alzheimer's, so it would be extremely useful to be able to identify those who are at greater risk of converting using a clinical test or biological measurement," said the study's lead author, Susan Landau, a post-doctoral fellow at UC Berkeley's Helen Wills Neuroscience Institute and the Lawrence Berkeley National Laboratory.
"The field, in general, is moving toward ways to select people during earlier stages of Alzheimer's disease, including those who show no outward signs of cognitive impairment," said Dr. William Jagust, a faculty member of UC Berkeley's Helen Wills Neuroscience Institute and principal investigator of the study. "By the time a patient is diagnosed with Alzheimer's disease, there is usually little one can do to stop or reverse the decline. Researchers are trying to determine whether treating patients before severe symptoms appear will be more effective, and that requires better diagnostic tools than what is currently available."
In the latest study, researchers compared
|Contact: Sarah Yang|
University of California - Berkeley