Navigation Links
Melanomas may appear noticeably different than other moles
Date:1/21/2008

A preliminary study suggests that melanomas have a different appearance than other irregular skin moles (i.e., are ugly ducklings), according to a report in the January issue of Archives of Dermatology, one of the JAMA/Archives journals.

Rates of malignant melanoma continue to increase, and early identification allows surgeons to treat the disease by removing the tumor, according to background information in the article. The disease is more common in individuals with many moles or other skin marks, especially if the marks are atypical in color, shape or size. The challenge for clinicians who diagnose and treat pigmented skin lesions is to distinguish between malignant melanoma and benign simulants, the authors write.

Alon Scope, M.D., of the Memorial Sloan-Kettering Cancer Center, New York, and colleagues obtained images of the backs of 12 patients from a database of standardized patient images. All of the patients had at least eight atypical moles, and five patients had one lesion that had been confirmed as a melanoma. Thirty-four study participantsincluding eight pigmented lesion experts, 13 general dermatologists, five dermatology nurses and eight non-clinical medical staffwere asked to evaluate the images and identify lesions that looked different from all other atypical moles.

All five melanomas and only three of 140 benign lesions (2.1 percent) were generally apparent as different, meaning that two-thirds of the participants identified them as ugly ducklings. The malignant melanomas were apparent as being different to at least 85 percent of participants, whereas the agreement rate on the benign lesions perceived as being different was 76 percent at most, the authors write. Four lesions were generally apparent as completely different, all four being malignant melanomas.

For all participants, the test had a sensitivity of 90 percent, meaning 90 percent of the melanomas were identified as different. Sensitivity was 100 percent for the pigmented lesion experts, 89 percent for general dermatologists, 88 percent for nurses and 85 percent for non-clinicians.

Although the sensitivity and specificity and diagnostic accuracy of the ugly duckling sign depended on clinical expertise, the values for these parameters were good in all subgroups of participants, the authors write. These preliminary findings suggest that the ugly duckling sign may prove to be a useful screening strategy for primary health care providers and even for skin self-examination.


'/>"/>

Contact: Jeanne D'Agostino
646-227-3573
JAMA and Archives Journals
Source:Eurekalert

Related medicine news :

1. Oral osteoporosis meds appear to reduce the risk of jaw degradation
2. Testosterone supplementation for older men appears to have limited benefit
3. Receptor protein appears to be key in breakdown of kidney filtration
4. Robotic device appears useful for surgical removal of cancer involving the tonsils
5. Molecular pathway appears crucial in development of pulmonary fibrosis
6. Amsterdam Native and St. Jude Patient Christian Gizara to Appear With Marlo Thomas on Dec. 8 Larry King Live to Educate Viewers About Life-Saving Work of St. Jude Childrens Research Hospital(R)
7. Follow-up imaging of benign-appearing incidental adrenal masses is unnecessary
8. Amsterdam Native and St. Jude Patient Christian Gizara to Appear With Marlo Thomas on Nov. 30 Larry King Live to Educate Viewers About Life-Saving Work of St. Jude Childrens Research Hospital(R)
9. Huge numbers willing to go under knife to alter their appearance, study finds
10. MS that runs in families appears more severe than non-familial MS
11. Nourishment Is Essential to a Youthful Appearance. Time to Feed Your Face with Serum_G
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... VA (PRWEB) , ... February 12, 2016 , ... ... Feb. 29, 2016 — 1:30 p.m. – 3:00 p.m. EST, http://www.fdanews.com/fixeddosecombination ... in the life cycle of pharmaceutical products, garnering increased attention from all stakeholders ...
(Date:2/12/2016)... ... ... Coco Libre, the maker of coconut water beverages with a purpose, is ... Coco Libre will offer musicians and celebrities the company’s signature Organic Coconut Water, a ... suite, held this year at the W Hollywood Hotel, has become a pre-show “must” ...
(Date:2/12/2016)... ... February 12, 2016 , ... ... (WaaS), today announced the integration of Clarity Intelligence Platform (CIP) into Cielo®, a ... offer real-time business intelligence (BI) to their small and medium business (SMB) clients. ...
(Date:2/12/2016)... ... 2016 , ... AssureVest Insurance Group, a locally owned insurance firm with offices ... raise funds earmarked to purchase computers and software for Mrs. Harrison’s 2nd and 3rd ... in a low-income area and has more than 60 2nd and 3rd graders with ...
(Date:2/12/2016)... , ... February 12, 2016 , ... Erlanger Agency has ... greater Columbus, OH area. The latest campaign focuses on the fight against breast cancer, ... are now being accepted here . , Carmen is a loving single mother ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... -- Eli Lilly and Company (NYSE: LLY ) today announced ... vitamin regimen patent would not presently be infringed by Actavis ... , Italy and Spain ... dextrose solution.  --> --> ... held that Lilly,s patent would be indirectly infringed by Actavis ...
(Date:2/12/2016)... , 12 februari 2016 ... een toonaangevende leverancier van productie en ontwikkeling ... industrieën, kondigt vandaag een uitbreiding aan van ... haar locatie in Charleston, SC ... geleid tot meerdere recente investeringen. ...
(Date:2/12/2016)... Maharashtra, February 12, 2016 ... report titled Chronic Inflammation Global Clinical Trials Review, ... of the global clinical trials landscape along with ... by Region, Country (G7 & E7), Trial Status, ... and reviews top companies involved and enlists all ...
Breaking Medicine Technology: