Navigation Links
Melanoma uses body's immune system to spread to lungs
Date:10/7/2010

The way melanoma cells use the immune system to spread and develop into lung tumors may lead to a therapy to decrease development of these tumors, according to Penn State researchers.

"Melanoma is the most aggressive and metastatic form of skin cancer," said Gavin Robertson, professor of pharmacology, pathology, dermatology and surgery in the Penn State College of Medicine. "Therefore, identifying proteins and molecular mechanisms that regulate metastasis is important for developing drugs to treat this disease."

Metastasis is a complex process in which cancer cells detach from the primary tumor and migrate to other sites in the body by traveling through the lymphatic or blood circulatory systems. Researchers in the Foreman Foundation Melanoma Research Laboratory at Penn State developed a model to determine why the roughly one million tumor cells shed daily from a 1-gram melanoma tumor do not form more metastases in the lungs.

After intravenously injecting 1 million human melanoma cells in a mouse, Robertson and colleagues observed entrapment of many of these cells in the lung vessels. Within 24 hours, however, few cells were still present in the lungs.

"In this study, we show that entrapped, circulating melanoma cells can use a person's own immune cells -- specifically a type of white blood cell called neutrophils -- to control lung metastasis development," Robertson said. After injecting the mice with neutrophils an hour following the melanoma cell injection, cancer cell retention was increased in the lung by about three times.

Melanoma cells produce and secrete high levels of a protein called IL-8, which is used to attract neutrophils.

"For patients, this is important because a therapy preventing circulating melanoma cells from secreting IL-8 would have the potential to decrease lung metastasis development by about 50 percent by disrupting interaction of the cancer cells with neutrophils," Robertson said. "Metastases form by proteins on the melanoma and neutrophils interacting and forming physical connections. These connections promote anchoring of the melanoma cells to the lung vessel walls, enabling the cancer cells to migrate through the wall to form lung metastases."

Decreasing the secretion of IL-8 limits the interaction of melanoma cells with neutrophils, dropping the number of melanoma cells retained in the lungs by about half.


'/>"/>

Contact: Matt Solovey
msolovey@hmc.psu.edu
717-531-8606
Penn State
Source:Eurekalert

Related medicine news :

1. Scanning for skin cancer: Infrared system looks for deadly melanoma
2. Non-Melanoma Skin Cancers in the Millions and Rising
3. Late-stage melanoma results in economic burden
4. Clinical trial to test whether vaccine can effectively treat melanoma
5. Wistar scientists explain the persistence of melanoma through dynamic stemness
6. Tanning Beds Can Greatly Boost Melanoma Risk
7. U of M study definitively links indoor tanning to melanoma
8. Indoor Tanning Beds Increase Risk of Melanoma
9. Novel Drug Combats Advanced Melanoma
10. Combination treatment regimen not effective against advanced melanoma
11. New treatment method safe, effective for advanced melanoma patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... ... March 28, 2017 , ... ... Advanced Surgical, Inc. is thrilled to offer the recently FDA-approved Obalon Balloon System ... procedure adds to SkyLex Advanced Surgical’s already comprehensive list of weight-loss services. ...
(Date:3/28/2017)... ... , ... Oily skin is a common and unwelcomed occurrence in people of all ages, genders ... offer to the discussion of dealing with excess skin oil. “Oily skin is a challenge ... that can help remove the oily shine while keeping the skin fresh and clean,” says ...
(Date:3/27/2017)... ... March 27, 2017 , ... New patients who have ... sleep apnea treatment, with or without a referral. Sleep apnea is often left untreated ... daytime sleepiness, morning headaches and chronic snoring. , Dr. Braasch seeks to raise ...
(Date:3/27/2017)... ... March 27, 2017 , ... ... gain site attention and engagement over the household brands of Top-20 pharma by ... will discuss how partnering with the right outsourcing payments provider can provide the ...
(Date:3/27/2017)... ... 27, 2017 , ... Adding to its expanding portfolio of ... and NEJM Journal Watch, announces the release of NEJM Knowledge+ Pediatrics Board ... of pediatricians from leading medical centers. The content was then reviewed and approved ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... Elysium Health joins major pharmaceutical ... Cambridge academic scientists through ... Milner Therapeutics Institute today announces Elysium Health as a partner ... investment for collaborative projects with academic researchers in ... the first major research investment outside the U.S. for the ...
(Date:3/27/2017)... 2017 Therapix Biosciences Ltd. ... in the development of cannabinoid-based drugs, today announced ... the United States of 2,000,000 ... ordinary shares of the Company, at a price ... granted the underwriters a 45-day over-allotment option to ...
(Date:3/27/2017)... VANCOUVER, British Columbia , March 27, 2017 /PRNewswire/ ... of Directors has appointed William "Bill" Dubiel as President ... Dubiel was also elected to the Board of Directors ... serve as the Executive Chairman of LightIntegra. ... become LightIntegra,s next President and Chief Executive Officer. We,ve ...
Breaking Medicine Technology: