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Melanoma drug revs immune cells but cancer cells ignore it
Date:9/2/2007

work, says first author Gregory B. Lesinski, a research assistant professor in the department of molecular virology, immunology and medical genetics. The new findings are significant because they confirm that the immune system, and not the tumor cell, is the primary target of IFNa.

We show for the first time that even normal melanocytes are inherently less responsive to IFNa compared to immune cells. Melanocytes are the normal cells that, when cancerous, cause melanoma.

Some unknown factor in melanoma cells seems to turn down their response to IFNa, Lesinski explains. We are now trying to understand what that factor might be.


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Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University
Source:Eurekalert

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