Navigation Links
Melanoma drug revs immune cells but cancer cells ignore it
Date:9/2/2007

COLUMBUS , Ohio A new study shows that an important drug used in the treatment of malignant melanoma has little effect on the melanoma cells themselves. Instead, it activates immune-system cells to fight the disease.

The drug, called interferon alpha (IFNa), is used to clean up microscopic tumor cells that may remain in the body following surgery for the disease. It is the only drug approved for this purpose.

Researchers say that these findings underscore the need to develop ways to make melanoma cells more vulnerable to the drug, or to overcome the block within the cells that prevents them from responding to it.

The study showed that melanoma cells taken directly from patients, as well as those grown in the laboratory, respond poorly to IFNa, even when the drug is given at very high doses, while immune cells respond well to the same substance.

The study, led by researchers with the Ohio State University Comprehensive Cancer Center, is published in the journal Clinical Cancer Research.

IFNa is effective in only 10 to 20 percent of patients, but it's the best therapy available for these patients, and no therapies on the horizon have been proven any more effective, says principal investigator William E. Carson, III, professor of surgery and a melanoma specialist at Ohio State's James Cancer Hospital and Solove Research Institute.

It is critical that we understand exactly how this drug works and learn how to improve its effectiveness.

IFNa is an immune-system hormone made by the body to help other immune cells recognize and destroy developing tumors. As a drug, the substance is used to treat melanoma and other cancers.

Formerly, it was thought that IFNa acted directly on melanoma-tumor cells to stop their growth. But earlier research by Carson's laboratory and others suggested that the drug has a greater effect on the immune system.

The present study confirms that earlier work, says first author Gregory B. Lesinski, a research assistant professor in the department of molecular virology, immunology and medical genetics. The new findings are significant because they confirm that the immune system, and not the tumor cell, is the primary target of IFNa.

We show for the first time that even normal melanocytes are inherently less responsive to IFNa compared to immune cells. Melanocytes are the normal cells that, when cancerous, cause melanoma.

Some unknown factor in melanoma cells seems to turn down their response to IFNa, Lesinski explains. We are now trying to understand what that factor might be.


'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University
Source:Eurekalert

Related medicine news :

1. UV Radiation induces Melanoma
2. Reduction in melanoma death rate
3. Latest device for identifying Melanomas
4. Specialist surgeon not imperative in melanoma
5. Tumour marker for melanoma found
6. Melanoma caused by low DNA repair capacity
7. Hope for First New Melanoma Treatment in Decades
8. Turmeric Found To Slow Down Melanoma Growth
9. Gene in Melanomas
10. Antigenics Pharmaceuticals plans for Phase III trial of its Melanoma vaccine
11. Skin Cancer History Puts Post-menopausal White Women At Risk For Melanoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... A ... revolutionize the emergency ambulance transport experience for the millions of people who require ... has disrupted the taxi industry through the use of technology. Now, SmartEMS has ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... that was developed to enhance the health of felines. The formula is all-natural and ... main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are ...
(Date:6/25/2016)... Miami, FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton ... Plant City Observer , brings up a new, often overlooked aspect of head lice: ... The closing for fumigation is not a common occurrence, but a necessary one in the ...
(Date:6/25/2016)... , ... June 25, 2016 , ... On Friday, June ... a Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments ... of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott ...
(Date:6/24/2016)... ... 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out of ... verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. ... throw rocks at my other children and say he was going to kill them. ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Colombia , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new ... affiliate in Latin America . ... ... ... ...
(Date:6/23/2016)... , June 23, 2016 The vast majority ... outpatient dialysis facility.  Treatments are usually 3 times a ... per visit, including travel time, equipment preparation and wait ... but especially grueling for patients who are elderly and ... skilled nursing and rehabilitation centers for some duration of ...
(Date:6/23/2016)... June 23, 2016 The Biotechnology ... continues to present great opportunities to investors. Stock-Callers.com assesses ... Intrexon Corp. (NYSE: XON ), Vertex Pharmaceuticals ... (NASDAQ: ARNA ), and Regeneron Pharmaceuticals Inc. ... stocks and receive your complimentary trade alerts at: ...
Breaking Medicine Technology: