Navigation Links
Melanoma drug revs immune cells but cancer cells ignore it
Date:9/2/2007

COLUMBUS , Ohio A new study shows that an important drug used in the treatment of malignant melanoma has little effect on the melanoma cells themselves. Instead, it activates immune-system cells to fight the disease.

The drug, called interferon alpha (IFNa), is used to clean up microscopic tumor cells that may remain in the body following surgery for the disease. It is the only drug approved for this purpose.

Researchers say that these findings underscore the need to develop ways to make melanoma cells more vulnerable to the drug, or to overcome the block within the cells that prevents them from responding to it.

The study showed that melanoma cells taken directly from patients, as well as those grown in the laboratory, respond poorly to IFNa, even when the drug is given at very high doses, while immune cells respond well to the same substance.

The study, led by researchers with the Ohio State University Comprehensive Cancer Center, is published in the journal Clinical Cancer Research.

IFNa is effective in only 10 to 20 percent of patients, but it's the best therapy available for these patients, and no therapies on the horizon have been proven any more effective, says principal investigator William E. Carson, III, professor of surgery and a melanoma specialist at Ohio State's James Cancer Hospital and Solove Research Institute.

It is critical that we understand exactly how this drug works and learn how to improve its effectiveness.

IFNa is an immune-system hormone made by the body to help other immune cells recognize and destroy developing tumors. As a drug, the substance is used to treat melanoma and other cancers.

Formerly, it was thought that IFNa acted directly on melanoma-tumor cells to stop their growth. But earlier research by Carson's laboratory and others suggested that the drug has a greater effect on the immune system.

The present study confirms that earlier
'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UV Radiation induces Melanoma
2. Reduction in melanoma death rate
3. Latest device for identifying Melanomas
4. Specialist surgeon not imperative in melanoma
5. Tumour marker for melanoma found
6. Melanoma caused by low DNA repair capacity
7. Hope for First New Melanoma Treatment in Decades
8. Turmeric Found To Slow Down Melanoma Growth
9. Gene in Melanomas
10. Antigenics Pharmaceuticals plans for Phase III trial of its Melanoma vaccine
11. Skin Cancer History Puts Post-menopausal White Women At Risk For Melanoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... Parker & Sons, Inc. a ... heating, cooling and plumbing contractor services throughout Arizona ... in 2014 with regard to air-conditioning systems. Residential ... known for its incredibly hot summers. Working with ... and details of a wide variety of systems ...
(Date:12/25/2014)... 26, 2014 The click ... beauty, strength and durability. Today, the business announces ... is valid until Jan. 30, 2015. , Click ... traditional hardwood. BambooFlooringChina.com is a well-known brand in ... worldwide to find a reliable bamboo flooring supplier. ...
(Date:12/25/2014)... York, New York (PRWEB) December 25, 2014 ... the 2010 DePuy ASR hip recall ( http://www.consumerinjurylawyers.com/DePuy/ ) ... LLP reports. According to an Order issued in the ... 20th, the Court will convene an open conference on ... Building and United States Courthouse in West Palm Beach, ...
(Date:12/25/2014)... (PRWEB) December 26, 2014 Recently, Dylan ... dresses, has excitedly released its collection of discounted prom ... to Percy, a senior spokesman of the company, the ... of this promotion is to expand the UK market. ... in several different colors, lengths, and styles: A-line strapless, ...
(Date:12/25/2014)... BambooFlooringChina.com sells many bamboo products and the ... the company announces big discounts on its bamboo ... , BambooFlooringChina.com is the world’s leader in bamboo flooring. ... until Jan. 20, 2015. , The bamboo mats are ... natural thread. All the bamboo strips for the mats ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... ... ... they now offer pet insurance to the state of Hawaii. Beginning immediately, residents of ... and cat owners of Hawaii have more options when it comes to pet insurance. , , ...
... ... leader in biofeedback and Mediwatch plc team up to offer a range of pelvic ... ... diagnostic manufacturing company, and Thought Technology Ltd., the worldwide leading expert in biofeedback, have ...
... ... a nightmare for pets and their owners, without a safety system in place.,Pets Guardian ... an accident or other unforeseen event., , ... (PRWEB) July 2, 2010 -- With vacation time here and ...
... First ... multi -million dollar contract for Exclusive Distributorship rights this week with the U.A.E Embassy ... new revolutionary product First Defense Nasal Screens to the entire Arab World. , ... Washington D. C. (PRWEB) -- First ...
... A time of ... according to Washington, D.C., personal injury attorney Mike Abelson. , ... Washington, D.C. (PRWEB) July 4, 2010 -- There is no ... Abelson says. But on the holiday day designated to celebrate the freedoms we all ...
... Neuxpower, A ... 2010 Emerging Technology Vendor By CRN Magazine. , ... Philadelphia, PA (PRWEB) July 4, 2010 -- Neuxpower ( www.neuxpower.com ), a ... 2010 Emerging Technology Vendor by CRN Magazine. Neuxpower was one of a select group of ...
Cached Medicine News:Health News:Pet Insurance from Trupanion Becomes Available in Hawaii 2Health News:OEM Partnership Between Thought Technology Ltd. and Mediwatch plc 2Health News:OEM Partnership Between Thought Technology Ltd. and Mediwatch plc 3Health News:Pets Guardian Provides A Pet Safety System, Ensuring Pets Will Be Cared For In Case of a Personal Emergency 2Health News:Pets Guardian Provides A Pet Safety System, Ensuring Pets Will Be Cared For In Case of a Personal Emergency 3Health News:United Staes Company, First Defense Nasal Screens Signs Multi-Million Dollar Exclusive Distributorship Contract with U.A.E Company. 2Health News:Don't Drink and Drive on Fourth of July Weekend, Washington, D.C., Attorney Warns 2Health News:Neuxpower Selected as 2010 Emerging Technology Vendor by CRN Magazine 2
(Date:12/24/2014)... , Dec. 23, 2014 Tianyin ... company that specializes in patented biopharmaceutical, modernized traditional ... ingredients (API) today announced that the Company achieved ... Good Manufacturing Practice (GMP) certificate of TPI,s Qionglai ... Administration,s (CFDA). The public notice period is a ...
(Date:12/24/2014)... RALEIGH, N.C. , Dec. 23, 2014 /PRNewswire/ ... (NASDAQ: ENDP ) (TSX: ENL), and BioDelivery ... today that they have submitted a New Drug Application ... Food and Drug Administration (FDA).  Buprenorphine HCl Buccal Film ... enough to require daily, around-the-clock, long-term opioid treatment and ...
(Date:12/22/2014)... 2014  CytoSorbents Corporation (OTCQB:CTSOD), a critical care ... technology to help fight deadly inflammation in critically-ill ... today announced the appointment of Dr. Gregory ... Senior Vice President of Clinical Development, effective January ... Russo is an accomplished pediatric cardiothoracic surgeon ...
Breaking Medicine Technology:TPI QLF Achieved Public Notice Status of GMP Certification 2TPI QLF Achieved Public Notice Status of GMP Certification 3Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 2Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 3Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 4Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 5CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 3CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 4CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 5
... U.S. Food and Drug Administration today announced that it ... rejection in kidney transplant patients. The test, called QMS ... drug that helps prevent rejection in kidney transplants. ... Everolimus, marketed under the trade name Zortress, was approved ...
... Nephros, Inc. (OTC Bulletin Board: NEPH ), ... for therapeutic applications, infection control, and water purification, today ... offering to its existing stockholders have been distributed. ... in the prospectus related to the rights offering, Nephros ...
Cached Medicine Technology:FDA Clears Test to Help Patients With Kidney Transplants 2Nephros Has Commenced Rights Offering 2Nephros Has Commenced Rights Offering 3Nephros Has Commenced Rights Offering 4Nephros Has Commenced Rights Offering 5
Determination of Activated Partial Thromboplastin Time (APTT) by STA Analyzers. Cephalin reagent with kaolin activator....
Determination of Prothrombin Time (PT) by STA Analyzers (ISI~1.3).Freeze-dried rabbit brain thromboplastin with heparin inhibitor....
Determination of Prothrombin Time (PT)by STA Analyzers (ISI~1.8).Freeze-dried rabbit brain thromboplastin with heparin inhibitor....
The ALB method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of albumin in serum...
Medicine Products: