Navigation Links
Medinox Announces Clinical Results of Naproxen Prodrug
Date:5/26/2009

SAN DIEGO, May 26 /PRNewswire/ -- Medinox, Inc. (Carlsbad, CA) and its development partner, Logical Therapeutics, Inc. (Waltham, MA) announced the results of a double-blind, randomized, active comparator study of LT-NS001 (formerly MX-1094) vs naproxen, in subjects 45 to 70 years of age. LT-NS001 is a novel, patented NCE prodrug of the popular non-steroidal anti-inflammatory drug (NSAID) naproxen, which is being developed to significantly reduce the GI safety risks, including the formation of ulcers, associated with naproxen. Naproxen is widely regarded as the NSAID with the most favorable cardiovascular safety profile among all of the drugs in this class.

In this study, subjects underwent upper endoscopies at baseline and on day seven. Subjects receiving LT-NS001 experienced statistically significantly fewer endoscopically confirmed gastric ulcers compared to subjects receiving naproxen.

LT-NS001 is pharmacologically inactive as an NSAID in the GI tract, but once absorbed into the blood stream, it is converted rapidly and quantitatively to naproxen. It is being developed to provide therapeutic levels of naproxen while avoiding high local concentrations of naproxen in the GI tract, thereby reducing the local GI toxicity associated with conventional naproxen.

LT-NS001 has been studied in various randomized controlled single-dose and multiple-dose clinical studies. In all cases, there were no serious adverse events and LT-NS001 was well tolerated. Moreover, when the subjects were dosed twice daily with LT-NS001, plasma concentrations of naproxen were within the therapeutic range.

NSAIDs are the most common medications taken worldwide for the treatment of pain, inflammation, fever and arthritics, including both rheumatoid arthritis (RA) and osteoarthritis (OA). The use of NSAIDs is associated with serious side effects, the most frequent being an increased rate of gastric and duodenal ulcer
'/>"/>

SOURCE Medinox, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2

Related medicine news :

1. Healthy Rebates, Inc. Announces the Launch of My HSA Rewards
2. Pro-cell Announces a Knock at the Door of Emerging Markets
3. March of Dimes Announces Nursing Scholarship Recipients
4. The Gout & Uric Acid Education Society (GUAES) Announces New Survey Results Highlighting Major Gaps in Public Awareness of Gout
5. AIM Health Group Inc. reports largest quarterly profit since going public and announces filing of financial results for the three months ended March 31, 2009 on SEDAR
6. Cephalon Announces Exercise of $65 Million Over-allotment Option on 2.50% Convertible Senior Subordinated Notes
7. QLT Announces Court Response to Motion to Dismiss and Removal of Case to Federal Court
8. Authentidate Holding Corp. Announces Results From Annual Meeting of Stockholders
9. Secretary Shinseki Announces $215 Million in Projects for Rural Veterans
10. Perot Systems Announces Special Financing Options for Stimulus Plan Healthcare Technology Upgrades
11. Medstrat Announces Integration of Echoes With MacPractices EMR
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... 28, 2014 Spine Guide has built ... of information on spinal health. Now, the e-health site ... people suffering from back pain symptoms. Spine Guide specializes ... surgery, and lumbar spine surgery. , Some of the ... or stabbing pain, pain radiating down the leg, inability ...
(Date:8/27/2014)... The National League for Nursing is pleased to ... became the inaugural director of the NLN/Chamberlain College ... of Nursing Education , effective August 11. The center ... for Transformative Excellence, established with the League’s historic move ... Under Dr. Dennis’s leadership, the NLN/Chamberlain Center will expand ...
(Date:8/27/2014)... Recently, Skmen.com, a renowned garment manufacturer ... celebrity bodycon dresses . The company has rich experience ... trendy items in stock and ready to ship: celebrity ... sleeve sweater dresses and so forth. All of them ... , “We are proud to announce the new collection ...
(Date:8/27/2014)... Philadelphia, PA. Inc. magazine ranked ... 500 list, an exclusive ranking of the nation’s fastest-growing ... look at the most important segment of the economy ... early exposure as members of the Inc. 500 list ... , “Some of world’s greatest companies have had their ...
(Date:8/27/2014)... 2014 All Canada Goose Parkas ... go from classic to modern. With unique detailing such as ... them is a step up in opulence. Recently, the company ... Parkas for 2014. , True enough, the new ... great discounts (up to 28% off) on all these brand ...
Breaking Medicine News(10 mins):Health News:Spine Guide Offering New Overview of Surgical Options For Back Pain 2Health News:Betty Pierce Dennis to Lead NLN/Chamberlain College of Nursing Center for the Advancement of the Science of Nursing Education 2Health News:Betty Pierce Dennis to Lead NLN/Chamberlain College of Nursing Center for the Advancement of the Science of Nursing Education 3Health News:Betty Pierce Dennis to Lead NLN/Chamberlain College of Nursing Center for the Advancement of the Science of Nursing Education 4Health News:Skmen.com Unveils Its New Celebrity Bodycon Dresses for Its Loyal Customers 2Health News:Inc Magazine Unveils 33rd Annual List of America's Fastest-Growing Private Companies - the Inc. 500 2Health News:CanadaGooseJackor.nu: 2014 Canada Goose Banff Parkas At Discounted Prices 2
... Anti-fungal and anti-bacterial additives in house paint are present ... the city of Lausanne, says a study to be ... Union (AGU) conference in San Francisco. Chemicals engineered to ... in order to prevent molding and plant growth. Washed ...
... By Alan Mozes HealthDay Reporter , FRIDAY, Dec. ... is just one more form of entertainment. But for Katie ... true cause for celebration. "It was absolute redemption," said ... Michael, 16-year-old son Dylan, and 14-year-old son Dusty -- who ...
... GREENVILLE, S.C. From their fourth-floor state-of-the-art laboratory in ... University bioengineering scientists and students help keep the feet ... new facility, which opens this week, houses one of ... hip, knee and other artificial joints that were removed ...
... certain form of inherited hearing loss have increased ... study by Professor Thomas Jentsch of the Leibniz-Institut ... Medicine (MDC) Berlin-Buch and Professor Gary Lewin (MDC), ... and Nijmegen, the Netherlands. The research findings, which ...
... , FRIDAY, Dec. 9 (HealthDay News) -- Premature infants ... than full-term babies, new research shows. However, the ... Candida fungus, are also more dangerous, researchers from Duke University ... [full-term] infants, whereas in premature infants, they seem to be ...
... were common and long-lasting during the first two ... a new study from Johns Hopkins University School ... factor for impaired physical function. "Early identification ... as a potential,intervention to improve long-term outcomes in ...
Cached Medicine News:Health News:Model shows how façade pollutants make it into the environment 2Health News:Broadway Strikes an Autism-Friendly Chord 2Health News:Broadway Strikes an Autism-Friendly Chord 3Health News:Broadway Strikes an Autism-Friendly Chord 4Health News:Clemson University opens bioengineering research lab at Greenville hospital campus 2Health News:Clemson University opens bioengineering research lab at Greenville hospital campus 3Health News:People with DFNA2 hearing loss show increased touch sensitivity 2Health News:People with DFNA2 hearing loss show increased touch sensitivity 3Health News:Preemies Infected With More Dangerous Types of Bacteria: Study 2Health News:Depressive symptoms and impaired physical function are frequent and long-lasting after ALI 2
(Date:8/27/2014)... , Aug. 27, 2014 Reportbuyer.com ... Collaborative R&D Terms & Agreements ... https://www.reportbuyer.com/product/2276220/Collaborative-RD-Terms--Agreements-in-Pharma-Biotech-and-Diagnostics.html The Collaborative R&D ... Diagnostics report provides comprehensive understanding and unprecedented ... agreements entered into by the worlds leading ...
(Date:8/27/2014)... FAIRFAX, Va. , Aug. 27, 2014 ... in the legs due to buildup of fatty plaque ... expected in the aging patient population and in incidences ... Radiology offers its Lower Extremity Arterial RevascularizatioN ... Ariz. Endovascular specialists and interested residents and ...
(Date:8/27/2014)...  Decision Resources Group finds that physicians surveyed ... gastroenterology, endocrinology and nephrology) expect the robustness and ... been assessed in to be the strongest influencers ... Other key findings from the ... of Biosimilars Across Physician Specialties : ...
Breaking Medicine Technology:Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 2Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 3Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 4Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 5Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 6Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 7Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 8Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 9LEARN to Treat Peripheral Arterial Disease Patients 2LEARN to Treat Peripheral Arterial Disease Patients 3Surveyed Physicians Expect to Choose Between Future Biosimilars Based on Robustness and Number of Clinical Trials 2
... CT Colonography Trial Raise Questions for,Patients, OAK ... CT Colonography Trial, published in the September 18 ... improvements in the technology,s,ability to diagnose intermediate- to ... testing is not as effective in diagnosing small ...
... September 18th New England Journal of,Medicine, Each year ... these deaths could be prevented by regular screening. Yet, ... be screened for the disease are,not being tested - ... with current screening exams., However, results of an ...
Cached Medicine Technology:ASGE Encourages Patients to Speak to Their Doctor About Colorectal Cancer Screening Options 2ASGE Encourages Patients to Speak to Their Doctor About Colorectal Cancer Screening Options 3ASGE Encourages Patients to Speak to Their Doctor About Colorectal Cancer Screening Options 4ASGE Encourages Patients to Speak to Their Doctor About Colorectal Cancer Screening Options 5MultiVu Video Feed: Major Trial Demonstrates Comparable Accuracy of Virtual Colonoscopy and Standard Colonoscopy 2
Inquire...
Inquire...
Inquire...
One Piece: Premier Pouches - Premier pouches provide the ultimate in skin protection with our long wearing Flextend skin barriers and superior comfort with our soft and silky ComfortWear panels....
Medicine Products: