Navigation Links
Medications used to treat rheumatoid arthritis may affect abortion rate in women
Date:4/15/2013

A new study published in the American College of Rheumatology (ACR) journal, Arthritis Care & Research, reveals that women with rheumatoid arthritis (RA) who were on methotrexate (MTX), a drug commonly used to reduce inflammation caused by RA, had lower rates of induced abortions compared to women with RA who were not exposed to the medication. Findings indicate that women with RA exposed to anti-tumor necrosis factor (anti-TNF) drugs may have increased abortion rates compared to unexposed women.

Experts estimate that 1.3 million U.S. adults have RAan inflammatory disease where the immune system attacks the lining of the joints causing pain, swelling, stiffness, and ultimately may lead to loss of joint function. RA can affect women during their reproductive years, placing them at risk for unplanned pregnancies. In fact, one study has shown that up to half of pregnancies in North America are unplanned, and nearly half of these unintended pregnancies are terminated.

A 2003 study by Chakravarty et al. found that while 96% of rheumatologists in the U.S. had recommended birth control to female RA patients of childbearing age who were starting MTX, only 55% followed-up with patients regarding their use of contraceptives. "Women with RA who become pregnant may have disease-specific reasons which might influence their decision to end a pregnancy. Exposure to teratogenic drugs, such as MTX, which can affect the development of the fetus, is one such reason women with RA may choose an induced abortion," explains lead author, Dr. velyne Vinet, from the Montreal General Hospital of the McGill University Health Centre (MUHC) in Canada.

To expand evidence of induced abortion rates in women with RA exposed to MTX, the team performed a nested case-control study using Quebec's physician billing and hospitalization databases from 1996 to 2008. Women with RA who were between the ages of 15 and 45 were identified, with cases classified as women who had an induced abortion. MTX exposure was defined as filling a prescription for the drug less than 16 weeks prior to the date of abortion.

The team identified 112 women with RA who had an induced abortion (cases) and 5855 RA controls. Close to 11% of cases and 22% of controls were exposed to MTX. Compared to the unexposed controls, women with RA who were exposed to MTX had a lower rate of induced abortions. Further analysis found a potential increase in the rate of induced abortions among women exposed to anti-TNF drugs, such as Enbrel, Humira, and Remicade.

"Our study shows that women with RA who were on MTX had lower rates of induced abortions, while those exposed to anti-TNF medications had potentially higher abortion rates" concludes Dr. Vinet. "These findings highlight the importance of research on reducing the number of unplanned pregnancies in women with RA taking MTX or TNF inhibitors. Further examination of counseling practices and contraceptive use is warranted to further reduce the need for abortions in women with RA."


'/>"/>

Contact: Dawn Peters
sciencenewsroom@wiley.com
781-388-8408
Wiley
Source:Eurekalert

Related medicine news :

1. Midtown Dentistry Combats Mouth Wounds During Radiation Treatment with New Medications
2. UCLA study finds heart failure medications highly cost-effective
3. Know Whats in Your Childs Medications, FDA Warns
4. Certain Diabetes Medications May Lower Heart Failure Risk
5. Tomorrows life-saving medications may currently be living at the bottom of the sea
6. Common anti-fever medications pose kidney injury risk for children
7. New UAlberta research shows commonly prescribed medications could have adverse effects
8. Study provides guidance for use of acid-suppressive medications in hospital patients
9. Fake Drugs Entering the U.S.: Lawyers at Console & Hollawell Highlight Federal Warnings About Counterfeit Medications
10. New delivery method improves efficacy of 2 common Parkinsons disease medications
11. Reducing off-label use of antipsychotic medications may save money
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/16/2017)... GA (PRWEB) , ... January 16, 2017 , ... ... to announce their recent partnership with an innovator in the wheelchair accessibility industry, ... to motivate their dealer salespeople to sell wheelchair accessible vehicles. With this new ...
(Date:1/16/2017)... ... ... One thing common to all types of cancer is that it’s a ... money spent screening for and treating cancer in the United States is estimated to ... than in any other country that has an advanced healthcare system, sometimes spending as ...
(Date:1/15/2017)... ... January 15, 2017 , ... Going above and ... that strives to better communities around the world by offering the Gensuite team ... the opportunity for team members to become involved in a cause that is ...
(Date:1/15/2017)... ... 14, 2017 , ... Wondering where to go this Valentine's Day? Well, there ... for a romantic, lobster feast in the comfort of your own home. Lobster Gram ... dinners will be featured until February 15th, 2017. , Romantic Dinner one is ...
(Date:1/14/2017)... ... January 14, 2017 , ... AgileMinder develops innovative products and services ... Scale is now available on Apple as a fun, free emoji sticker pack for ... one of the ten color coded values on The Emoji Scale. , On ...
Breaking Medicine News(10 mins):
(Date:1/16/2017)... and PUNE, India , January ... by Allied Market Research, titled, "Vital Signs Monitoring Devices Market ... Forecast, 2014-2022", projects that the global vital signs monitoring devices ... expected to reach $5,491 million by 2022, growing at a ... America was the leading regional market in global ...
(Date:1/16/2017)... Oregon and PUNE, India , January 16, 2017 ... Research, titled, "Antioxidants Market by Type - Global Opportunity Analysis and Industry Forecast, ... is expected to reach $4,531 million by 2022, registering a CAGR of 6.42% ... for more than one-third share of the global volume in 2015. ... ...
(Date:1/16/2017)... 16, 2017  Dovetail Genomics today announced the commercial ... service, which yields chromosome-scale genome assemblies. The service is ... workshop on Jan. 17 at the Plant & Animal ... . "We are thrilled to be ... our Dovetail Hi-C offering," said Todd Dickinson , ...
Breaking Medicine Technology: