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Medications found to cause long term cognitive impairment of aging brain
Date:7/13/2010

tive impairment which involves gradual memory loss. As a geriatrician I tell my Wishard Healthy Aging Brain Center patients not to take these drugs and I encourage all older adults to talk with their physicians about each and every one of the medications they take," said Malaz Boustani, M.D., IU School of Medicine associate professor of medicine, Regenstrief Institute investigator and IU Center for Aging Research center scientist.

"The fact that we found that taking anticholinergics is linked with mild cognitive impairment, involving memory loss without functional disability, but not with Alzheimer Disease, gives me hope. Our research efforts will now focus on whether anticholinergic-induced cognitive impairment may be reversible," said Dr. Boustani, who added that "this study offers a new window to change the burden of dementia" for the individual, the caregiver and the healthcare system."

"This finding of a link between anticholinergics and long term mild cognitive impairment complements our previous work which confirmed a link between anticholinergics and delirium, which is a sudden onset cognitive impairment," said Dr. Campbell.

Although this study, which was funded by the National Institute on Aging, looked at only African-Americans, both Dr. Campbell and Dr. Boustani believe future studies will find that the results are generalizable to other races.


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Contact: Cindy Fox Aisen
caisen@iupui.edu
317-274-7722
Indiana University School of Medicine
Source:Eurekalert  

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