Navigation Links
Medication may prevent depression in patients with head and neck cancer
Date:5/19/2008

Taking the antidepressant citalopram before beginning treatment for head and neck cancer may help prevent depression during therapy, according to results of a pilot study published in the May issue of Archives of OtolaryngologyHead & Neck Surgery, one of the JAMA/Archives journals.

Treatment for head and neck cancer can be arduous and debilitating, the authors write as background information in the article. Psychiatric morbidity in these patients is frequent and underdiagnosed. Major depressive disorder has been reported in up to 40 percent of patients with head and neck cancer, typically within the first three months of diagnosis.

William M. Lydiatt, M.D., of the University of Nebraska Medical Center and Nebraska Methodist Hospital, Omaha, and colleagues conducted a randomized clinical trial involving patients with head and neck cancer. Before beginning treatment, 15 participants were randomly assigned to receive 40 milligrams of the antidepressant citalopram daily and 13 were randomly assigned to take placebo. The patients took the medications for 12 weeks, during which time they underwent cancer treatment and were screened for depression every four weeks. Twenty-two patients were assessed at week 12, and 23 patients completed a final study visit four weeks after stopping the medication.

The numbers of subjects who met predefined cutoff criteria for depression during the 12 weeks of active study were five of 10 (50 percent) taking placebo and two of 12 (17 percent) taking citalopram, the authors write. No patients in the citalopram group became suicidal, compared with two in the placebo group. Quality of life, as measured by a self-administered questionnaire, deteriorated in both groups during treatment but less so in the group taking citalopram.

The data from this pilot trial suggest that prevention of major depressive disorder in patients undergoing treatment for head and neck cancer may be an attainable goal. The data show trends toward major depressive disorder prevention in this small sample. All measures of psychiatric well-being favored the group taking citalopram, the authors conclude. This study suggests a tangible means to improve outcome in patients with head and neck cancer and supports additional research toward this aim.


'/>"/>

Contact: Vicky Cerino
402-559-5190
JAMA and Archives Journals
Source:Eurekalert

Related medicine news :

1. American Academy of Pediatrics/American Heart Association Clarification of Statement on Cardiovascular Evaluation and Monitoring of Children and Adolescents With Heart Disease Receiving Medications for ADHD
2. Migraine Medications May Cause Serotonin Syndrome
3. Chronic Medication Nation: Research Finds Chronic Health Problems Now Afflict More Than Half of All Americans
4. Nations First of its Kind Consumer Medication Return Initiative Creates Momentum for Safe Drug Disposal in the U.S.
5. Study affirms effectiveness of medication for juvenile rheumatoid arthritis
6. Self-Medication One of Many Factors Driving OTC Drug Market Past $80 Billion by 2012
7. Quarter of Disabled Seniors Use Risky Medications
8. CNS Response, Inc.: Poster Session on Referenced-EEG Guided Medication to Be Presented at the American Psychiatric Association 161st Annual Meeting
9. Common Medications Could Cause Physical Impairment in the Elderly
10. Commonly used medications associated with impaired physical function in older adults
11. 1 in 10 children using cough, cold medications
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/16/2017)... ... August 16, 2017 , ... A global leader in the treatment ... clinics in all 29 Indian states—bringing the country one step closer to eliminating clubfoot ... the nonprofit organization is on track to enroll 10,000 children in the clubfoot treatment ...
(Date:8/16/2017)... Atlanta, Georgia (PRWEB) , ... August 16, 2017 , ... ... to distribute premium original programming over four countries and millions of viewers in a ... available to rent or buy On-Demand and fully available on Blu Ray disc in ...
(Date:8/16/2017)... ... August 16, 2017 , ... TopConsumerReviews.com recently gave a best-in-class 5 ... , The healthcare industry in the United States has undergone major changes over the ... needing to have a doctor’s order to get a blood test or other lab ...
(Date:8/16/2017)... , ... August 16, 2017 , ... First Choice ... States, named Dr. Douglas J. Harrison, as the new Medical Director of its Sienna ... new facility Medical Director of our Sienna Plantation location,” said Dr. Michael (Derek) Caraway, ...
(Date:8/16/2017)... ... August 16, 2017 , ... With low back pain afflicting 8 of 10 Americans at some ... cousin – upper back pain. But this equally vexing condition stems from a variety of ... Kaixuan Liu, MD, PhD , founder and president of Atlantic Spine Center. , Nestled ...
Breaking Medicine News(10 mins):
(Date:7/31/2017)...  Diplomat Pharmacy, Inc. (NYSE: DPLO), has been named one ... by Crain,s Detroit Business . The annual ... three-year revenue growth. This year,s edition measures growth from 2013 ... the complete list, visit crainsdetroit.com/awards/fast_50/2017 .  ... said Phil Hagerman , CEO and chairman of Diplomat. ...
(Date:7/27/2017)... Holdings, Inc. (NYSE and SIX: ZBH) today reported financial results ... reported second quarter net sales of $1.954 billion, an ... an increase of 2.1% on a constant currency basis.  ... LDR Holding Corporation acquisition, second quarter 2017 revenues decreased ... on a constant currency basis. ...
(Date:7/26/2017)... The Galien Foundation announced today the 2017 11 ... Award Nominees. Counted among the global health innovation industry,s most ... technology product achievement that improves the human condition. ... be U.S. Food and Drug Administration (FDA) approved for market ... impact human health. Sales data are not considered by the ...
Breaking Medicine Technology: