Navigation Links
Medical researchers ID potential new drug target that could stop debilitating effects of MS
Date:10/26/2011

Medical researchers at the University of Alberta have discovered a potential new drug target for Multiple Sclerosis that could prevent physical disability associated with the disease, once a new drug is developed.

In the first phase of MS, those with the condition have lots of inflammation of their brain cells, resulting in continuous cycles of inflammation attacks followed by recovery periods. In the second phase of the disease, the inflammation isn't as severe, but this is the stage where physical disability sets in due to the effects from substantial numbers of brain cells being killed in the first phase of the disease.

When immune cells become active due to inflammation, they can pass through the blood-brain barrier and enter the central nervous system. Some of these activated immune cells secrete a molecule, known as granzyme B, that can get inside neurons and wreak havoc ultimately causing brain cell death. Granzyme B is found in MS brain lesions especially in the early stages of inflammation. This molecule can get into brain cells through a "gatekeeper," known as receptor M6PR.

Researchers with the Faculty of Medicine & Dentistry discovered in lab experiments that if they prevent this granzyme B from entering neurons, "we can also prevent the killing of neurons," says principal investigator Fabrizio Giuliani, whose work was recently published in the peer-reviewed publication, The Journal of Immunology.

"It is this loss of brain cells, in the long-term, which induces disability in those with MS," he says. "This is a new drug target for MS that is specific for the neurodegenerative processes following inflammation."

Giuliani, a researcher in the Division of Neurology and a practising neurologist, noted this latest research builds on previous findings by his colleagues within the faculty. Medical researcher and co-author Chris Bleackley made an earlier discovery about how granzyme B enters target cell
'/>"/>

Contact: Raquel Maurier
raquel.maurier@ualberta.ca
780-492-5986
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Page: 1 2

Related medicine news :

1. TheReliefPlace.com Launches Online Store “The Relief Shop” - What Does this Medical Supply Store Carry and How Can They Help You?
2. Medical Transcription Services and EHR Provider MxSecure Launches New Enhanced Website with Goal of Improved Physician Productivity
3. Medical Training School, Pima Medical Institute Offering First Bachelor's Degree Program
4. FDA Seeks Reduction in Radiation From Medical Scans
5. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
6. University of Virginia Health System Medical Laboratories Selects Sunquest's Specimen Collection Solution
7. Medical Imaging Northwest Completes Phase I of Its Healthcare IT Integration to Maintain Patient Care Improvements
8. Centene Corporation Hosts Medical Management Systems Update in New York City
9. CelebrityDiagnosis.com Nominated as Best New Medical Blog of 2009
10. Medical Malpractice Survivors Urge President Obama to Keep Tort Reform out of Health Insurance Bill
11. Tufts Medical Center and Boston Medical Center Nurses Hold a Joint Informational Picket to Protest Unsafe Staffing and Practice Conditions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 2015 The federal court overseeing thousands of ... Court, Southern District of West Virginia has upheld a $2 ... first bellwether trial. In an Order dated January 21st, the ... finding that C.R. Bard had not proven a miscarriage of ...
(Date:1/22/2015)... January 22, 2015 Thousand of GranuFlo ... Care recalled its GranuFlo and NaturaLyte dialysis concentrates continue ... in U.S. District Court, District of Massachusetts, Bernstein Liebhard ... the Court has remanded a case filed by the ...
(Date:1/22/2015)... 2015 Carinsurancesavings.biz has released a new blog ... dismemberment insurance . , Purchasing an accidental death and ... advantageous. This type of rider provides benefits if the insured ... considered a lesser form of life insurance. , AD&D ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Yesterday, ... Bonilla (D-Concord) and Kristin Olsen (R-Modesto) were honored ... leadership in advancing biotechnology, biomedical science, medical device ... Olsen each received the “2014 Life Sciences Champion” ...
(Date:1/22/2015)... 2015 Four years since the release of their ... with the marriage of Avasa & Matthew Love – the duo ... scheduled for release through White Swan Records on February 24, 2015. ... a sacred path available to all of us to walk out ...
Breaking Medicine News(10 mins):Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4
... , THURSDAY, Nov. 11 (HealthDay News) -- Many ... and dinner, meals that provide nutrients critical to youngsters, ... found. The American Dietetic Association Foundation poll of ... 17) found that breakfast is sometimes missed by 42 ...
... therapy (ADT) for prostate cancer may have an increased ... online November 10 in The Journal of the ... is a widely-prescribed treatment in men with prostate cancer, ... the adverse side effects, including osteoporosis, cardiovascular disease, diabetes ...
... 13% of the United States population, are living with ... grow. If current trends continue, there will not be ... To help address this crisis, the American Society of ... Workforce during its upcoming ASN Renal Week 2010 in ...
... and heavy drinking on college campuses continue to be ... the University of Missouri, have made strides in efforts ... trying to educate students about the risks of excessive ... who viewed images of beer cans packaged and displayed ...
... activity provides more than just pleasure, University of Cincinnati ... anxiety responses in the brain. The findings were ... PNAS , the official journal of the National ... PhD, research assistant professor, James Herman, PhD, director of ...
... By Amanda Gardner HealthDay Reporter , WEDNESDAY, Nov. ... emaciated lung cancer patients, a dead body in a morgue, ... secondhand smoke) and other consequences of smoking that will appear ... into quitting the habit or not starting in the first ...
Cached Medicine News:Health News:Many Kids Skipping Meals, Snacking Instead 2Health News:Colorectal cancer risk increases in prostate cancer patients on androgen deprivation therapy 2Health News:ASN leads efforts to address growing crisis in kidney care 2Health News:Team colors on cans change perceptions of alcohol risks, MU study finds 2Health News:Pleasurable behaviors reduce stress via brain pathways, research shows 2Health News:FDA Proposes Graphic Warnings on Cigarette Packs 2Health News:FDA Proposes Graphic Warnings on Cigarette Packs 3
(Date:1/22/2015)... , Jan. 22, 2015  Amgen (NASDAQ: AMGN ) today ... 2014 financial results on Tuesday, Jan. 27, 2015, after the close ... a conference call with the investment community at 2 p.m. PT. ... Bradway , chairman and chief executive officer, and other members of ...
(Date:1/22/2015)...  Profil Institute for Clinical Research, Inc., a clinical research ... a new textbook,  Translational Research Methods for Diabetes, Obesity ... global scientific publisher. The textbook is the ... in early phase clinical studies of new drugs for ...
(Date:1/22/2015)... Research and Markets ( http://www.researchandmarkets.com/research/3h534b/infectious ) has ... Market by Product, Application, Technology, End User - Global ... The infectious disease diagnostics market is expected ... million by 2019 from $12,422.8 million in 2014. Increase ...
Breaking Medicine Technology:Amgen Announces Webcast of 2014 Fourth Quarter and Full Year Financial Results 2New Textbook "Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development" Provides Critical Review Of Current And Emerging Clinical Investigation Methods 2New Textbook "Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development" Provides Critical Review Of Current And Emerging Clinical Investigation Methods 3Global Infectious Disease Diagnostics (Instruments, Reagents, Services, Software) Market - Forecast to 2019 2Global Infectious Disease Diagnostics (Instruments, Reagents, Services, Software) Market - Forecast to 2019 3
... 20 Pittsburgh -based Foundation Radiology Group ... proud to announce its strategic partnership with Acusis, a national provider ... , , , ... in Pittsburgh , Acusis delivers healthcare solutions that are designed ...
... 20 Medical Device Consultants, Inc. (MDCI), a ... the medical device and diagnostics industry, today announced a ... (CDSS), a clinical services and CRO based in ... to the best of both organizations, core strengths and ...
Cached Medicine Technology:Foundation Radiology Group Forms Strategic Partnership with Transcription Experts, Acusis 2Foundation Radiology Group Forms Strategic Partnership with Transcription Experts, Acusis 3Medical Device Consultants, Inc. and Clinical Development & Support Services Ltd Announce Strategic Partnership 2Medical Device Consultants, Inc. and Clinical Development & Support Services Ltd Announce Strategic Partnership 3
The ACCU-Beam® line of Surgical Microscope Accessories includes digital camera adaptors, beam splitters, objective lenses, fiber optic cables, and fiberoptic retrofits....
The ACCU-Beam® line of Surgical Microscope Accessories includes digital camera adaptors, beam splitters, objective lenses, fiber optic cables, and fiberoptic retrofits....
... of Surgical Microscope Accessories includes digital camera ... cables, and fiberoptic retrofits. TTI Medical's patented ... 5,264,928) is the only adaptor that will ... the same adaptor body. It is fully ...
... line of Surgical Microscope Accessories includes ... lenses, fiber optic cables, and fiberoptic ... Adaptor allows the surgeon to document ... either video or 35mm photography. Many ...
Medicine Products: