Navigation Links
Medical University of South Carolina Leads Multicenter Study Evaluating Biliary Sphincter Disorder
Date:9/26/2007

$6 Million Grant Funded by NIDDK

CHARLESTON, S.C., Sept. 26 /PRNewswire/ -- The Medical University of South Carolina (MUSC) will lead a $6 million study to determine the best techniques for diagnosing and treating sphincter of Oddi dysfunction (SOD), a painful condition that causes narrowing or spasm of the muscle that controls the flow of bile and pancreatic juice into the small intestine.

The national principal investigator for this five-year, multicenter, research project is Peter Cotton, MD, professor of medicine-gastroenterology and hepatology and founder of the Digestive Disease Center at MUSC.

The study, called Evaluating Predictors and Interventions in Sphincter of Oddi Dysfunction (EPISOD), is funded by a grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health and involves five other major research sites.

More than half a million patients undergo surgical removal of the gallbladder (cholecystectomy) annually in the United States, predominantly for gallbladder disease. Although most operations are successful, 10 to 20 percent of patients report persistent episodes of pain after surgery.

Some of these patients are found to have new gallstones, or other conditions such as pancreatitis. When these causes are excluded, SOD is suspected. Dysfunction of the sphincter (narrowing or spasm) can cause back pressure in the liver or pancreas, resulting in severe attacks of pain and significant interference with daily living.

The focus of this study is to clarify how best to detect and exclude SOD, and how best to treat it. Currently, patients with suspected SOD are usually referred to special centers, including those involved in the study, and undergo multiple tests.

The standard treatment is endoscopic retrograde cholangiopancreatography (ERCP), which allows complete documentation of the relevant anatomy, assessment of any sphincter spasm by measuring the pressure with manometry, and immediate treatment by cutting the sphincter (sphincterotomy).

This process has not been subjected to controlled scientific trial, which is deemed necessary for two reasons: Only about 60 percent of these patients experience lasting relief, and both ERCP and sphincterotomy carry significant risks.

EPISOD is aimed at determining the best candidates for treatment by analyzing the patients' characteristics (pain patterns, presence of other digestive function disorders and psychological factors), measuring the sphincter pressures at ERCP and allocating treatment to sphincterotomy or control. Study participants will be followed for at least one year to assess their outcomes and need for further treatment.

Results of the EPISOD trial should provide patients and practitioners with the scientific evidence to more effectively and safely treat patients with suspected SOD.

Dr. Cotton's colleagues on this study include researchers from MUSC; the University of North Carolina; the University of Michigan; Johns Hopkins University; Indiana University; the University of Alabama; Virginia Mason Medical Center, Seattle; and the University of Minnesota, Minneapolis.


'/>"/>
SOURCE Medical University of South Carolina
Copyright©2007 PR Newswire.
All rights reserved

Related medicine news :

1. Check if your “Favourite medical web-site” is indulging in Quackey
2. Teens turning to Internet for medical queries
3. Robots craft medical history
4. NBE to conduct test for medical students from abroad
5. Air pollution combined with greater medical needs
6. Indian Nationals with Foreign Medical Degrees can now practice in India
7. Children! Protecting them from medical mistakes
8. More information sought by patients on medical errors
9. SARS necessitates medical masks
10. Meditation Works Medically
11. Sleep Disorders Could Indicate Other Medical Problems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/4/2016)... (PRWEB) , ... December 04, 2016 , ... Are You ... of the most certified and experienced Indoor Air Quality Companies in VA, MD and ... Remediation Regulations. , The new mold law in the district of Columbia ...
(Date:12/2/2016)... ... , ... Two years ago, Arizona State University students produced ... 1 million viewers and won numerous honors, including the region’s top Emmy and ... Cronkite School of Journalism and Mass Communication are following up their award-winning investigation ...
(Date:12/2/2016)... ... , ... Advanced Inc., a leading provider of travel therapy and travel nursing ... as Advanced Inc.’s Chief Financial Officer, effective December 1, 2016. Jason previously served as ... operational leadership experience to Advanced Inc. He began his career in finance at Ernst ...
(Date:12/2/2016)... ... December 02, 2016 , ... U.S. Surgeon General, Dr. Vivek ... Dr. Murthy explains how he was inspired to practice medicine at an early age ... is about more than making diagnoses and prescribing medicine,” he states. “It is about ...
(Date:12/2/2016)... ... ... More than half of American teens report losing their virginity before they ... child about sex related topics, less than 60 percent spoke about deeper themes like ... launch of its second edition of the “Sexual Wellness” campaign, aiming to address the ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... -- Quantum Radiology,s Mobile Breast Center (QR MBC) brings ... women at the workplace, thereby maximizing convenience and compliance.  ... Lines and SunTrust Bank, and community health groups to ... initiatives. "I think it,s a great service ... have a mammogram without taking a large amount of ...
(Date:12/2/2016)... On Thursday, December 1st 2016, ... research, development and innovation in the biopharmaceutical industry at ... in the presence of Sergey Tsyb, Vice Minister of ... , Natalia Sanina, First Vice Chairman of the ... of Roszdravnadzor, National Service of Control in Healthcare, Sergey ...
(Date:12/2/2016)... 2, 2016  Maxor National Pharmacy Services, LLC ("Maxor"), today ... Inc. ("PSI").  The combination of Texas -based ... -based PSI bring together both company,s clinical expertise and high-touch ... an industry-leading specialty pharmacy. About Maxor ... , , ...
Breaking Medicine Technology: