Navigation Links
Medical University of South Carolina Leads Multicenter Study Evaluating Biliary Sphincter Disorder
Date:9/26/2007

$6 Million Grant Funded by NIDDK

CHARLESTON, S.C., Sept. 26 /PRNewswire/ -- The Medical University of South Carolina (MUSC) will lead a $6 million study to determine the best techniques for diagnosing and treating sphincter of Oddi dysfunction (SOD), a painful condition that causes narrowing or spasm of the muscle that controls the flow of bile and pancreatic juice into the small intestine.

The national principal investigator for this five-year, multicenter, research project is Peter Cotton, MD, professor of medicine-gastroenterology and hepatology and founder of the Digestive Disease Center at MUSC.

The study, called Evaluating Predictors and Interventions in Sphincter of Oddi Dysfunction (EPISOD), is funded by a grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health and involves five other major research sites.

More than half a million patients undergo surgical removal of the gallbladder (cholecystectomy) annually in the United States, predominantly for gallbladder disease. Although most operations are successful, 10 to 20 percent of patients report persistent episodes of pain after surgery.

Some of these patients are found to have new gallstones, or other conditions such as pancreatitis. When these causes are excluded, SOD is suspected. Dysfunction of the sphincter (narrowing or spasm) can cause back pressure in the liver or pancreas, resulting in severe attacks of pain and significant interference with daily living.

The focus of this study is to clarify how best to detect and exclude SOD, and how best to treat it. Currently, patients with suspected SOD are usually referred to special centers, including those involved in the study, and undergo multiple tests.

The standard treatment is endoscopic retrograde cholangiopancreatography (ERCP), which allows complete documentation of the relevant anatomy, assessment of any sphincter spasm by measuring the pressure with manometry, and immediate treatment by cutting the sphincter (sphincterotomy).

This process has not been subjected to controlled scientific trial, which is deemed necessary for two reasons: Only about 60 percent of these patients experience lasting relief, and both ERCP and sphincterotomy carry significant risks.

EPISOD is aimed at determining the best candidates for treatment by analyzing the patients' characteristics (pain patterns, presence of other digestive function disorders and psychological factors), measuring the sphincter pressures at ERCP and allocating treatment to sphincterotomy or control. Study participants will be followed for at least one year to assess their outcomes and need for further treatment.

Results of the EPISOD trial should provide patients and practitioners with the scientific evidence to more effectively and safely treat patients with suspected SOD.

Dr. Cotton's colleagues on this study include researchers from MUSC; the University of North Carolina; the University of Michigan; Johns Hopkins University; Indiana University; the University of Alabama; Virginia Mason Medical Center, Seattle; and the University of Minnesota, Minneapolis.


'/>"/>
SOURCE Medical University of South Carolina
Copyright©2007 PR Newswire.
All rights reserved

Related medicine news :

1. Check if your “Favourite medical web-site” is indulging in Quackey
2. Teens turning to Internet for medical queries
3. Robots craft medical history
4. NBE to conduct test for medical students from abroad
5. Air pollution combined with greater medical needs
6. Indian Nationals with Foreign Medical Degrees can now practice in India
7. Children! Protecting them from medical mistakes
8. More information sought by patients on medical errors
9. SARS necessitates medical masks
10. Meditation Works Medically
11. Sleep Disorders Could Indicate Other Medical Problems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... , ... While it’s often important to take certain medications during the night, ... has identified a solution. , She developed a prototype for MOTION LIGHT-UP PILL BOX ... eliminates the need to turn on a light when taking medication during the night, ...
(Date:10/13/2017)... QUEENS, N.Y (PRWEB) , ... October 13, 2017 , ... ... recently became a member of ElderCounsel, a national organization of elder law and special ... constantly changing laws and rules. It also provides a forum to network with elder ...
(Date:10/13/2017)... ... ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many kids this ... by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids excited about ... ages; it is a non-competitive, non-timed event, which is all about having fun and ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and ... of published author, William Nowers. Captain Nowers and his wife, Millie, have six ... years in the Navy. Following his career as a naval aviator and carrier ...
(Date:10/12/2017)... CITY, Fla. (PRWEB) , ... October 12, 2017 , ... ... cold therapy products, announced today the introduction of an innovative new design of the ... multipurpose pad so you get maximum comfort while controlling your pain while using cold ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... ORANGE COUNTY, Calif. , Oct. 10, 2017  NDS received ... Mobile  — a medical-grade battery-powered display stand specifically designed for ... aims to transform technology into a clinical solution to support the ... costs. Innovative Design ... NDS ZeroWire Mobile Wireless Solution ...
(Date:10/4/2017)... 4, 2017  According to the Centers for Disease Control and Prevention ... . PhysicianOne Urgent Care is helping communities across Massachusetts ... , by offering no-cost* flu shots through the end of the month. ... health insurance regulations. ... to get a flu shot is by the end of October, according ...
(Date:10/2/2017)... -- Halo Labs announces the European launch of their new low ... MIBio 2017 in Cambridge, U.K on October ... biopharmaceutical samples with unprecedented speed and sensitivity while using far less ... Imaging. ... analysis system ...
Breaking Medicine Technology: