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Medical College of Wisconsin study finds drug may limit radiation kidney damage in BMT patients
Date:11/14/2007

opril is an angiotensin-converting enzyme (ACE) inhibitor; a class of drugs that help relax blood vessels, and is currently approved by the U.S. Food and Drug Administration for treatment of hypertension, heart failure, and diabetic nephropathy. Because Captopril may cause leukopenia, the study drug was not started until the new marrow had engrafted in the participants. Leukopenia is a condition in which the white blood cells fall below normal.

The three-week delay in administration of the drug was justified by our animal studies in the late 1990s which showed that a delayed start of captopril could successfully prevent radiation injury to the kidney, Says Dr. Cohen.

In an earlier 1992 animal study, published in Radiation Research, we found that captopril was effective in treating chronic kidney damage and its progression after total body irradiation. That showed that normal tissue radiation injury can be treated, he says.


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Contact: Toranj Marphetia
toranj@mcw.edu
414-456-4744
Medical College of Wisconsin
Source:Eurekalert

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