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Medical College of Wisconsin researchers identify proteins that help develop mammalian hearts
Date:5/16/2008

in a redundant manner, Dr. Duncan said. However, when both GATA4 and GATA6 genes were mutated, the embryonic stem cells were unable to form heart cells in the lab.

The study observed how the absence or mutation of GATA4 and GATA6 proteins impacted heart development in mice embryos. The embryos were cloned from GATA4 and GATA6 deficient stem cells.

When embryos were cloned from normal stem cells, they made normal beating hearts, Dr. Duncan explained. However, when embryos were cloned from the GATA4/GATA6 deficient stem cells, the embryos developed but were completely lacking all heart cells.


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Contact: Toranj Marphetia
toranj@mcw.edu
414-456-4744
Medical College of Wisconsin
Source:Eurekalert

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