Navigation Links
Medical College of Wisconsin researchers identify proteins that help develop mammalian hearts
Date:5/16/2008

The absence of two proteins in mammalian embryos prevents the development of a healthy heart, a new study by researchers at the Medical College of Wisconsin, Milwaukee, has found.

The study, which appears in the May 15 issue of Developmental Biology, was led by Stephen Duncan, Ph.D., professor of cell biology, neurobiology and anatomy at the Medical College.

This is the first study that has successfully identified the factors responsible for the onset of heart formation in the mammalian embryo. Until now, no single mutation had been identified that was thought to be responsible for blocking proper development of the heart in mammalian embryos. The identification of these major developmental switches will allow researchers to unravel the fundamental mechanisms that define heart cell formation.

Understanding the molecular pathways that control the development of the heart has been the subject of much interest in the scientific community, as approximately 35,000 children are born in the United States each year with congenital heart defects. Many more die during gestation because of complications from improper heart development.

Defining these molecular pathways has implications in the production of heart cells from stem cells, said Dr. Duncan. Our study suggests that mutations in GATA4 and GATA6 are likely contributors to the development of congenital heart disease in children. Indeed other investigators at our Medical College, as well as elsewhere, have found mutations in one of the genes from our study in children born with heart abnormalities.

Dr. Duncans lab found that either of two proteins, GATA4 and GATA6, controls the expression of genes that tell early embryonic cells to start making other proteins that eventually become beating heart cells.

When either GATA4 or GATA6 were present, the stem cells were able to make most of the proteins that are required for heart function suggesting that they act in a redundant manner, Dr. Duncan said. However, when both GATA4 and GATA6 genes were mutated, the embryonic stem cells were unable to form heart cells in the lab.

The study observed how the absence or mutation of GATA4 and GATA6 proteins impacted heart development in mice embryos. The embryos were cloned from GATA4 and GATA6 deficient stem cells.

When embryos were cloned from normal stem cells, they made normal beating hearts, Dr. Duncan explained. However, when embryos were cloned from the GATA4/GATA6 deficient stem cells, the embryos developed but were completely lacking all heart cells.


'/>"/>

Contact: Toranj Marphetia
toranj@mcw.edu
414-456-4744
Medical College of Wisconsin
Source:Eurekalert

Related medicine news :

1. Select Medical Corporation Announces Results for First Quarter Ended March 31, 2008
2. The 2008 AMIA Spring Congress to Showcase Best Practices and Innovations in Biomedical and Health Informatics Research and Education
3. Americans must consider cost and effectiveness when comparing and choosing medical interventions
4. AGA Medical Corporation Receives CE Mark Approval for the AMPLATZER(R) Vascular Plug III
5. Nonin(R) Medical Pioneers First Interoperable, Wireless Fingertip Pulse Oximeter
6. CRH Medical Corporation opens Center in New York
7. Mindray Medical Completes Acquisition of Datascopes Patient Monitoring Business
8. RNC RESPONSE TO OBAMA COMMENTS ON MEDICAL MARIJUANA LAWS
9. LMS Medical Sees Fiscal 2008 Revenue Jump 72% Over F07 - Q4/F08 Revenue Hits New Record
10. UNICEF Rushing Medical Supplies, Tents, Clean Water to Children Affected by Powerful Earthquake in China
11. Milliman Says 2008 Medical Cost for American Family of Four Exceeds $15,600
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... RIDGE, N.J. (PRWEB) , ... October 13, 2017 , ... ... annual Holly Day Market. Featuring a collection of specialty vendors and unique items from ... of personalized and quality-focused health and wellness services offered by the VNA. The ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual ... in Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon ... fun run is geared towards children of all ages; it is a non-competitive, non-timed ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor Rob Lowe, ... in a new episode of "Success Files," which is an award-winning educational program ... investigates each subject in-depth with passion and integrity. , Sciatica occurs when the ...
(Date:10/13/2017)... ... 2017 , ... “The Journey: From the Mountains to the Mission Field”: the ... in the Philippines. “The Journey: From the Mountains to the Mission Field” is the ... She has taught all ages and currently teaches a class of ladies at her ...
(Date:10/12/2017)... WILMINGTON, Del. (PRWEB) , ... October 12, 2017 ... ... technology and advisory services for healthcare compliance program management, will showcase a range ... and National Association for Assisted Living (NCAL) Convention and Expo to be held ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... , Oct. 11, 2017  Caris Life Sciences ® ... fulfilling the promise of precision medicine, today announced that ... Caris, Precision Oncology Alliance™ (POA) as its 17 th ... the St. Jude Crosson Cancer Institute will help develop ... use of tumor profiling, making cancer treatment more precise ...
(Date:10/11/2017)...  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today provided ... Piedras, Puerto Rico , where the ... Following a comprehensive onsite ... structural damage, temporary loss of power and minimal water ... manufacturing operations have resumed, and the company expects to ...
(Date:10/10/2017)... 10, 2017   West Pharmaceutical Services, Inc. ... injectable drug administration, today shared the results of a ... improving the intradermal administration of polio vaccines. The study ... in May 2017 by Dr. Ondrej Mach , ... Health Organization (WHO), and recently published in the journal ...
Breaking Medicine Technology: