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Mechanism of breathing muscle 'paralysis' in dreaming sleep identified
Date:11/15/2012

The brain chemical mediating this powerful inhibition of breathing muscle activity in REM sleep is acetylcholine, acting via muscarinic receptors that are functionally linked to a particular class of potassium channel.

"Since REM sleep recruits mechanisms that can abolish or suppress tongue muscle activity during periods of REM sleep and cause obstructive sleep apnea, identification of a mechanism mediating this inhibition is a significant discovery," said Dr. Horner.

"This newly identified process has fundamental implications for understanding the common and serious problems of snoring and other breathing problems such as obstructive sleep apnea, which are worse in REM sleep," said Dr. Horner. "Moreover, identifying the fundamental mechanism responsible for the shutting down of a muscle in sleep that is critical for effective breathing also identifies a rational drug target designed to prevent this inactivity and so prevent obstructive sleep apnea and other sleep-related breathing problems."


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Contact: Nathaniel Dunford
ndunford@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Page: 1 2

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