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Mechanism of breathing muscle 'paralysis' in dreaming sleep identified
Date:11/15/2012

A novel brain mechanism mediating the inhibition of the critical breathing muscles during rapid eye movement (REM) sleep has been identified for the first time in a new study, offering the possibility of a new treatment target for sleep-related breathing problems.

The findings were published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

"REM sleep is accompanied by profound inhibition of muscle activity," said researcher Richard Horner, PhD, professor of medicine and physiology at the University of Toronto This "paralysis" affects breathing muscles and "is a cause of snoring and other breathing problems in sleep, especially obstructive sleep apnea."

Sleep apnea is a common and serious problem that increases the risk for heart attacks, high blood pressure, stroke, diabetes and daytime sleepiness.

According to Dr. Horner, "the brain mechanism mediating inhibition of the critical breathing muscles in REM sleep was unknown, but a novel and powerful inhibitory mechanism is identified for the first time in our study."

In the study, performed by PhD student Kevin Grace, rats were studied across sleep-wake states. The researchers targeted manipulation of the brain region that controls tongue muscles during sleep.

The tongue is an important breathing muscle because its activity keeps the airspace open behind the tongue to allow for the effective passage of air into the lungs. Inhibition of tongue muscle activity in sleep in some people leads to backward movement of the tongue and blockage of the airspace. This blockage in sleep leads to episodes of self-suffocation (sleep apnea) that are rescued by waking up from sleep. Such episodes can occur hundreds of times a night.

Importantly, the muscle activating effects of these interventions were largest during REM sleep and minimal or absent in other sleep-wake states.
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Contact: Nathaniel Dunford
ndunford@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

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