Navigation Links
Mechanism of blood clot elasticity revealed in high definition
Date:2/25/2008

His data indicated that the fibrinogen molecule elongates in a sequential fashion, with three distinct phases. But he could not tell which parts of the fibrinogen molecule were involved.

Fibrinogen is a symmetrical molecule, containing a central region connected to two end regions by long, interweaving coiled chains, called alpha helices. These coiled coils were believed to give the molecule its elasticity. But how"

The Illinois team used a computational approach to tackle the mystery. Using steered molecular dynamics (SMD), they modeled the behavior of every atom of the fibrinogen molecule as it was stretched. The computation involved more than a million atoms, and required six months to complete.

The resulting simulation (see movie) generated a force extension curve that matched the one Lim had produced.

This was an incredibly strong piece of evidence that what (Lim) saw wasnt just in the eye of the beholder, but he saw really a property of the protein, Schulten said.

The simulation also showed in molecular detail how the fibrinogen molecule responded to stretching. Each phase in the force extension curve corresponded directly with a distinct set of events in the elongation of the molecule.

The simulations revealed that the extension occurs in a specific and orderly pattern, with distinct regions within the coiled-coil unraveling before others, the authors wrote.

Lim had also demonstrated that changes in calcium levels or in the pH (acidity) of a blood clot could alter fibrinogen elasticity, a finding that could influence the design of pharmaceutical agents.

By understanding what happens at the molecular level, you can understand where to target drugs, Lee said.

This study points to the efficacy of combining molecular dynamics simulations with experimental data on actual molecules, Schulten said. This is pro
'/>"/>

Contact: Diana Yates
diya@uiuc.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert  

0

GOOD

Page: 1 2 3

Related medicine news :

1. Who found some new mechanisms of HBV virulence?
2. Japan Backs Away from Making Real Changes to Its Rx Pharma Pricing Mechanism
3. Oregon researchers discover a mechanism leading to cleft palate
4. Quality control mechanism tags defective sperm cells inside the body
5. Study suggests nicotine addiction might be controlled by influencing brain mechanisms
6. St. Jude Finds Mechanism for Faulty Protein Disposal
7. St. Jude finds mechanism for faulty protein disposal
8. Research suggests mechanism for acne drugs link to depression
9. Researchers chart the genetic mechanisms behind the genesis of fat cells
10. Researchers at IRB Barcelona discover one of the mechanisms that prevents the spread of colon cancer
11. UCSD study reveals the regulatory mechanism of key enzyme
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mechanism of blood clot elasticity revealed in high definition
Mechanism of blood clot elasticity revealed in high definition
(Date:12/16/2009)... Balance, Inc. (Nasdaq: SMBL ) announced today that ... repurchase program of up to $25 million, to begin ... we have in the prospects of our Company and ... of our shareholders, while at the same time making ... Inc. Chairman and Chief Executive Officer. ,, Any purchases ...
(Date:12/16/2009)... Immucor, Inc. (Nasdaq: BLUD ), a global leader ... industry, today announced that Paul D. Mintz, M.D. has ... director, effective January 1, 2010. ,, Dr. Mintz ... for more than 30 years. He is a tenured ... Virginia School of Medicine. He also serves as director ...
(Date:12/16/2009)... result of C3: Colorectal Cancer Coalition,s advocacy efforts, $15 ... is included in the final Fiscal Year 2010 Defense ... will research cancers, like colorectal cancer, that are not ... research programs run by the U.S. Army Medical Research ... in funding for this new cancer research program was ...
(Date:12/16/2009)... Wellcome Trust Sanger Institute announce the first comprehensive analyses ... by mutations in the DNA of cancer cells which ... a malignant melanoma and a lung cancer, reveal for ... genomes of two cancers. , Lung cancer causes around ... associated with smoking. The number of mutations found suggest ...
(Date:12/16/2009)... to Ensure and Encourage Access to Quality, Cost-Effective Care , ... ... members of Congress have debated the best ways to rein in ... care reform. An important part of the ongoing discussion includes ... health care providers besides doctors of medicine (MDs) or osteopathy (DOs). ...
Breaking Medicine News(10 mins):Health News:Smart Balance Authorizes Stock Repurchase Program 2Health News:Immucor Appoints New Board Director 2Health News:House Creates New Cancer Research Program 2Health News:House Creates New Cancer Research Program 3Health News:Lung cancer and melanoma laid bare 2Health News:Lung cancer and melanoma laid bare 3Health News:Lung cancer and melanoma laid bare 4Health News:Lung cancer and melanoma laid bare 5Health News:Lung cancer and melanoma laid bare 6Health News:Coalition for Patients' Rights: Access to Broad Range of Health Care Providers Critical to Lowering Costs 2Health News:Coalition for Patients' Rights: Access to Broad Range of Health Care Providers Critical to Lowering Costs 3Health News:Coalition for Patients' Rights: Access to Broad Range of Health Care Providers Critical to Lowering Costs 4Health News:Coalition for Patients' Rights: Access to Broad Range of Health Care Providers Critical to Lowering Costs 5
... for measuring blood pressure in children based on age, weight, ... as young as age 3 should receive regular blood pressure ... for blood pressure are diagnosed with high blood pressure. Kids ... said to have pre-hypertension -- a relatively new classification aimed ...
... each year. On average, men who smoke shorten their lives ... their life expectancy by about 15 years . Latest research ... Surgeon General’s Report showed smoking was linked to cancers of ... both men and women. Doctors now say that there are ...
... New research shows about half of the population carries a ... tube defects like spina bifida to their offspring.// Researchers say ... processing folate in the body is linked to neural tube ... be associated with the birth defects. ,Researchers studied about ...
... rise among men, report researchers who conducted a study, which ... the incidence of breast cancer in men climbed from 0.86 ... during the 25-year study. ,Researchers say that breast cancer ... so rare among males, accounting for less than 1 percent ...
... cases of skin cancer are diagnosed. More than 5 million ... 7,000 people die yearly. Now, doctors are using a new ... ,Mary Louise Gramkow spent her life in the sun. ... thing. [I am] just an outdoor person.” All that sun ...
... on rats with spinal cord contusions -- the most ... consisted of transplanted Schwann cells, which is a type ... molecule called cyclic AMP, and the antidepressant Rolipram. ... not provide a proper environment for nerve regeneration. However, ...
Other Medicine News:
(Date:12/16/2009)... A new application developed by ... review of specialty pharmaceuticals has increased health plan ... while reducing costs. ,, AIM, a leading diagnostic ... plan clients representing over 35 million consumers and ... WLP ), adapted the successful clinical and ...
(Date:12/16/2009)... Inc. (Pink Sheets: AVXT) ("AVAX" or the "Company") ... loan financing (the "2009 Financing") pursuant to a ... with Firebird Global Master Fund, Ltd., ("Firebird"). Pursuant ... promissory note, due June 30, 2010, in the ... warrant to purchase an aggregate of 93,333,333 shares ...
(Date:12/16/2009)... -- Boston Scientific Corporation (NYSE: BSX ) ... elected Nelda Connors as a Director. ,, ... Metal Products division of Tyco International. Previously, she ... positions in operations and general management. Prior to ... executive and management capacities with Ford, Chrysler and Mogami ...
Breaking Medicine Technology:American Imaging Management's New Specialty Drug Program Delivers Immediate Results 2American Imaging Management's New Specialty Drug Program Delivers Immediate Results 3American Imaging Management's New Specialty Drug Program Delivers Immediate Results 4AVAX Technologies, Inc. Closes Bridge Financing 2AVAX Technologies, Inc. Closes Bridge Financing 3AVAX Technologies, Inc. Closes Bridge Financing 4Boston Scientific Announces Election of Nelda Connors to Its Board of Directors 2Boston Scientific Announces Election of Nelda Connors to Its Board of Directors 3FindFloridaLawyer com Announces the Grand Opening of Its Online Attorney Search and Legal Resource Site 57360 1FindFloridaLawyer com Announces the Grand Opening of Its Online Attorney Search and Legal Resource Site 57360 2Amgen to Present Pivotal Data From Four Phase 3 Studies at the ECCO 15 ESMO 34 Congress 57358 1Amgen to Present Pivotal Data From Four Phase 3 Studies at the ECCO 15 ESMO 34 Congress 57358 2Amgen to Present Pivotal Data From Four Phase 3 Studies at the ECCO 15 ESMO 34 Congress 57358 3Amgen to Present Pivotal Data From Four Phase 3 Studies at the ECCO 15 ESMO 34 Congress 57358 4Amgen to Present Pivotal Data From Four Phase 3 Studies at the ECCO 15 ESMO 34 Congress 57358 5Amgen to Present Pivotal Data From Four Phase 3 Studies at the ECCO 15 ESMO 34 Congress 57358 6Amgen to Present Pivotal Data From Four Phase 3 Studies at the ECCO 15 ESMO 34 Congress 57358 7Amgen to Present Pivotal Data From Four Phase 3 Studies at the ECCO 15 ESMO 34 Congress 57358 8Touro Appoints Alan Kadish M D Senior Provost and Chief Operating Officer 57356 1Touro Appoints Alan Kadish M D Senior Provost and Chief Operating Officer 57356 2Touro Appoints Alan Kadish M D Senior Provost and Chief Operating Officer 57356 3Touro Appoints Alan Kadish M D Senior Provost and Chief Operating Officer 57356 4
... Shenzhen Chipscreen Biosciences, Ltd., and HUYA Bioscience International, ... 1 trial conducted by Chipscreen of the investigational compound ... Society of Clinical Oncology (ASCO) Annual Meeting, which will ... in Orlando, Florida. Chidamide/HBI-8000 is a novel benzamide class ...
... clinical data, competitor focus, and new drug-eluting technologies to ... , according to Millennium Research Group WALTHAM, Mass., ... European Markets for Peripheral Vascular (PV) Devices 2009 ... procedures that treat lower extremity peripheral artery disease in ...
Other Medicine Technology:Chipscreen and HUYA Bioscience to Present Clinical Data on Novel HDAC Inhibitor at the 2009 ASCO Annual Meeting 2Lower Extremity Peripheral Vascular Stent and Balloon Catheter Markets to Exceed $180 Million in Europe by 2013 2Lower Extremity Peripheral Vascular Stent and Balloon Catheter Markets to Exceed $180 Million in Europe by 2013 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: