Navigation Links
Mechanism involved in addictions and some forms of obesity discovered in U of A lab
Date:10/4/2010

A researcher from the Faculty of Medicine & Dentistry at the University of Alberta has discovered a mechanism underlying some forms of obesity and addictions which could lead to a treatment for both diseases.

When a hungry animal finds food in the wild, it is a rewarding stimulus for the animal and is recognized by the brain by the release of the chemical messenger dopamine. Because narcotics such as cocaine, heroin and amphetamines, and even tasty and highly-caloric foods also cause the release of dopamine and therefore make people feel rewarded, it's clear that dopamine has a role in addiction and the development of obesity. When an animal knows it can expect rewarding stimuli, like a treat, in a certain location, either in the wild or captivity, this is called 'conditioned place preference' and is dependent on spatial memories being formed in a specific part of the brain called the dentate gyrus.

Professor Bill Colmers and his research group, in the department of pharmacology, set out to find if dopamine may have an effect on the memory-forming brain cells in the dentate gyrus. His group used living brain slices from laboratory models and were able to mimic activity in brain cells when an animal is exploring a novel environment. When dopamine was added, it increased the excitability in part of the brain cell called the dendrites. A chemical secreted by the brain, Neuropeptide Y, had the opposite effect making the cells less excitable.

They took this experiment further by looking at a model called long term potentiation, which is the name for a form of cellular learning. When the scientists stimulated dopamine receptors they found that cellular learning was strengthened. While doing the same experiment with neuropeptide Y, applied together with dopamine, it prevented long-term potentiation from happening

The group also did this in human brain slices taken from patients undergoing therapy for temporal lobe epilepsy. The human brain cells showed the same properties as cells found in rats, and they also undergo dopamine-dependent cellular learning when stimulated in the same fashion as the laboratory models.

Considering Colmers and his group's major focus is in obesity, this is a very exciting finding.

"You can find the fridge and you know there's good stuff in there, so you can find it in your sleep, and people do," said Colmers. "So there's this whole reward aspect to place that we've been able to unravel."

These results help explain the mechanisms that underlie the formation of reward-cued spatial memories in both the laboratory model and human dentate gyrus. Understanding this mechanism not only explains the biology of an important form of learning, but may also lead to potential treatments for addiction and obesity.


'/>"/>

Contact: Quinn Phillips
quinn.phillips@ualberta.ca
780-248-2048
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Related medicine news :

1. Key leukemia defense mechanism discovered by VCU Massey Cancer Center
2. Targeted therapy triggers complex mechanism of resistance
3. Scripps Research scientists solve long-standing mystery of protein quality control mechanism
4. New dual recognition mechanism discovered in tuberculosis
5. Scientists discover the mechanisms and function of a type of mysterious immune cell
6. Study of cell division sheds light on special mechanism in egg cells
7. New radiation mechanism may ward off cancer, oil spills and terrorism
8. Study makes exciting progress in elucidating the mechanisms of bortezomib in lymphoma
9. Scripps Research scientists uncover previously unknown natural mechanism that controls cocaine use
10. A key mechanism links virgin olive oil to protection against breast cancer
11. Mechanism that may trigger degenerative disease identified
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... ... today announced its strategic partnership with Connance, a healthcare industry leader providing ... companies’ proven, proprietary technology combine to provide health systems, hospitals and ambulatory ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, a Media ... give their videos a whole new perspective by using the title layers in ... Studios. , ProSlice Levels contains over 30 Different presets to choose from. ...
(Date:6/25/2016)... ... 2016 , ... Austin residents seeking Mohs surgery services, can now turn to ... Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to ... fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. ... from injury. Recently, he has implemented orthobiologic procedures as a method for treating ... one of the first doctors to perform the treatment. Orthobiologics are substances that ...
(Date:6/24/2016)... Michigan (PRWEB) , ... June 24, 2016 , ... June ... about the dangers associated with chronic pain and the benefits of holistic treatments, ... individuals who are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... , June 27, 2016 Jazz Pharmaceuticals ... waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of ... acquisition of Celator Pharmaceuticals, Inc. ("Celator"; Nasdaq: ... p.m. (Eastern Daylight Time). As previously announced ... into a definitive merger agreement under which Jazz Pharmaceuticals ...
(Date:6/24/2016)... HILL, N.C. , June 24, 2016 /PRNewswire/ ... healthcare decisions and regulators/payers have placed more emphasis ... new environment, patient support programs in the pharmaceutical ... for patients, medications. Consequently, pharmaceutical companies are focusing ... ensure they are providing products and services that ...
(Date:6/24/2016)...   Bay Area Lyme Foundation , collaborating ... for Tick Borne Illness , Harvard Medical School ... Medicine, University of California, Berkeley, and the Veterans ... finalists of Lyme Innovation , the first ... scientists, clinicians, researchers, entrepreneurs, and investors from several ...
Breaking Medicine Technology: