Navigation Links
Mechanism for invasion of tumorous cells discovered by Hebrew University researchers
Date:4/11/2011

Jerusalem, April 11, 2011 Researchers at the Hebrew University of Jerusalem have discovered a previously unknown mechanism whereby tumor cells invade normal tissues, spreading cancer through various organs.

The ability of tumor cells to invade adjacent structures is a prerequisite for metastasis and distinguishes malignant tumors from benign ones. Thus, understanding the mechanisms that drive malignant cells to invade and a possible avenue for halting that mechanism could have tremendous potential for enhancing early detection of malignant cells and for therapeutic treatment.

It has previously been assumed that tumor cells turn invasive upon accumulation of multiple mutations, each giving the cancer cell some invasive properties

Now, Prof. Yinon Ben-Neriah and Dr. Eli Pikarsky of the Institute for Medical Research Israel-Canada at the Hebrew University Faculty of Medicine and their colleagues are reporting an alternative mechanism through which tumor cells become invasive. They found a program that is operated by a concerted group of genes that, when activated together, confer invasive properties upon epithelial cells. (Epithelial tissues line the cavities and surfaces of structures throughout the body, and also form many glands.) An article reporting their work appeared in a recent issue of the journal Nature.

Interestingly, the expression of this entire gene group is normally suppressed by a single gene p53 that is considered as the most important tumor suppressor but unfortunately is inactivated in the majority of human cancers. Some key properties of the protein produced by the p53 gene -- arresting cell growth and induction of cell death were previously discovered by Dr. Moshe Oren of the Weizmann Institute of Science, another member of the current research team. These properties were thought to explain the main cancer protection activity of p53. However, the new research now described in Nature describes a different mechanism of action of p53 -- inhibition of cell invasion -- which may be the most critical means of cancer-protection in colon and rectal cancers and possibly other types of epithelial cancers.

Two Hebrew University doctoral students on the investigative team, Ela Elyada and Ariel Pribluda, developed a new mouse model in which they were able to demonstrate a process of genetically induced invasiveness of tumorous tissue and how that process could be prevented as long as p53 could be kept activated.

The new study may have important implications for cancer diagnosis and therapy.

The discovery of new invasion-activating genes could serve as diagnostic biomarkers for distinguishing malignant from benign lesions and the early detection of invasive cancer. This distinction is a critical determinant of therapeutic options, a judgment based today solely on microscopic study of tissue slides. With the availability of a prompt and exact molecular definition of invasive versus non-invasive lesions, lives could be saved by allowing the early implementation of curative treatments while withholding patient overtreatment, which often results in serious morbidity.

The reported findings may also indicate new measures for ways to maintain activation of p53 as a safeguard against malignant transformation of epithelial tissues.


'/>"/>

Contact: Jerry Barach
jerryb@savion.huji.ac.il
972-258-82904
The Hebrew University of Jerusalem
Source:Eurekalert

Related medicine news :

1. IU research team discovers TB disease mechanism and molecule to block it
2. UCR researcher identifies mechanism malaria parasite uses to spread in red blood cells
3. Tumor mechanism identified
4. Multiple sclerosis, Italian researchers discover a possible onset mechanism for the disease
5. Pancreatic Cancer Study Reveals Mechanism Initiating Disease, In Mice
6. Pancreatic cancer study reveals mechanism initiating disease, in mice
7. Study identifies 1 of the mechanisms behind breast cancer metastasis
8. Mechanism that may trigger degenerative disease identified
9. A key mechanism links virgin olive oil to protection against breast cancer
10. Scripps Research scientists uncover previously unknown natural mechanism that controls cocaine use
11. Study makes exciting progress in elucidating the mechanisms of bortezomib in lymphoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... ... April 28, 2016 , ... Accreditation Commission for ... Pharmacy Association (COPA) to develop a comprehensive Specialty Pharmacy Accreditation with Distinction in ... accreditation distinction. ACHC provides a wide range of pharmacy accreditation services that assess ...
(Date:4/28/2016)... ... April 28, 2016 , ... The Aging in Motion Coalition ... ICD-10-CM code for sarcopenia, giving it recognition for separate reporting and data collection. The ... 2016. , Sarcopenia is defined as a combination of low muscle mass and weakness ...
(Date:4/28/2016)... ... April 28, 2016 , ... The USDA recently released its updated Dietary Guidelines ... science. While there is a lot of information available in the report, older men ... 2016 issue of Harvard Men's Health Watch . , These include: , ...
(Date:4/28/2016)... ... April 28, 2016 , ... Dr. Farhan Qureshi has ... been named a 2015 Top Rated Alexandria Dentist from Find Local ... has received across many credible sources. Find Local Doctors is an online directory that ...
(Date:4/28/2016)... ... April 28, 2016 , ... Vigamox and other pink eye medications ... contagious infection of the mucus membrane of the eye. This membrane, the conjunctiva, ... eye, also called conjunctivitis, can be caused by a virus, bacteria, extreme dryness, chemicals ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... , April 28, 2016 Research ... "Global Plastic Surgery Products Market 2016-2020" report to ... ) , The global plastic surgery products ... 9.47% during the period 2016-2020. , ,The growing adoption ... to the growth of the market. Lasers are used ...
(Date:4/28/2016)... , Net Sales of $1.90 billion represent ... prior year period, and an increase of 1.2% on an ... for the first quarter were $0.52 reported, a decrease of ... increase of 29.9% over the prior year period , ... for 2016 Zimmer Biomet Holdings, Inc. (NYSE and ...
(Date:4/28/2016)... , April 28, 2016 ... development of innovative peptide and gene-based immunotherapeutics and vaccines for ... will be presenting at the 3rd Annual Growth Capital ... 5 th , 2016 at Caesars Palace in Las Vegas, Nevada.  ... am on Wednesday, May 4 th by Dr. ...
Breaking Medicine Technology: