Navigation Links
Mechanism for esophageal cancer uncovered
Date:4/11/2011

A gene thought to be associated with cancer development can be a tumor suppressor gene in mice, researchers have discovered. Understanding which genes are involved in spreading cancer could lead to future therapies.

"For cancer to spread, some genes are activated, while others that would prevent cancer growth are prevented from doing their jobs. The cancer research community has thought that the gene p120, falls into the latter category," said Douglas Stairs, Ph.D., assistant professor of pathology, who completed this research at University of Pennsylvania and is now at Penn State College of Medicine. "In this research, the loss of the p120 gene led to the development of cancer."

Stairs worked with colleagues at Vanderbilt University to create a mouse model to study the gene. Called a knockout mouse, these specially bred mice do not have the p120 gene in their mouths and esophagi. Researchers then studied the mice to see if tumors formed in those areas. In 70 percent of p120 knockout mice, tumors formed.

Researchers observed that mice that had cancer had hyperactivated immune systems. Absence of p120 led to the production of immune cells that are pro-tumor generating and pro-cancer forming.

"For cancer, the immune system can both help and hurt the body," Stairs said. "Some immune cells help the body get rid of the cancer cells, while other immune cells help tumors to form. When p120 was absent, tumor promotion through the immune system was activated. The mice produced the bad types of immune cells." The researchers published their results in the journal Cancer Cell.

Researchers learned through further investigation that these "bad" immune cells traveled to the esophagus and improperly activated fibroblasts. Fibroblasts are cells that create the support structure for tissues. They are most noticeably activated when tissue damage occurs and scarring is a result of the fibroblast cells activating. Fibroblasts are also activated in cancer patients.

By improperly activating the fibroblasts, the immune cells were able to stay active longer than normal.

"Each feeds off the other," Stairs said. "It creates an environment that is very permissive for cancer development." Stairs is now working to identify which proteins are used to communicate between tumor cells and other cells in the tumor microenvironment -- the immune cells and fibroblasts. He aims to discover how cells that lose p120 interact with the immune system, which, in turn, interacts with the fibroblasts. "Once we know that," he said, "we can then potentially develop a strategy to break those relationships -- a therapy."

The creation of the p120 knockout mouse will also help other researchers, providing a model for esophageal cancer that did not exist before.


'/>"/>

Contact: Matt Solovey
msolovey@hmc.psu.edu
717-531-8606
Penn State
Source:Eurekalert

Related medicine news :

1. Mechanism for invasion of tumorous cells discovered by Hebrew University researchers
2. Mount Sinai finds promising clue to mechanism behind gene mutation that causes Parkinsons disease
3. Scientists find key mechanism of childhood respiratory disease
4. Novel mechanism for control of gene expression revealed
5. Researchers find new mechanism behind the formation and maintenance of long-term memories
6. New study finds molecular mechanisms that control Rb2/p130 gene expression in lung cancer
7. Unexpected new mechanism behind rheumatoid arthritis
8. Princeton scientists discover mechanism involved in breast cancers spread to bone
9. UCLA researchers uncover new cell biological mechanism that regulates protein stability in cells
10. UCI researchers find novel memory-enhancing mechanism in brain
11. A new mechanism for reversible proteasome inhibition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes , ... mock evacuation of the facility as part of a disaster drill on October 3rd. ... EMS and Shelton City Emergency Manager, as well as the Connecticut Long Term ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... The Visiting ... Day Market. Featuring a collection of specialty vendors and unique items from across the ... and quality-focused health and wellness services offered by the VNA. The boutique will ...
(Date:10/13/2017)... NJ (PRWEB) , ... October 13, 2017 , ... Global ... at scenic Alexandria Park in Milford, NJ. This free event, sponsored by Global ... physical activity. The fun run is geared towards children of all ages; it ...
(Date:10/13/2017)... ... 13, 2017 , ... Talented host, actor Rob Lowe, is ... a new episode of "Success Files," which is an award-winning educational program broadcasted ... each subject in-depth with passion and integrity. , Sciatica occurs when the sciatic ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... ORLANDO, Fla. , Oct. 2, 2017  AllianceRx ... services company formed by Walgreens and pharmacy benefit manager ... of its new brand, which included the unveiling of ... Fla. , as well as at a few ... introduces the new brand to patients, some of whom ...
(Date:9/28/2017)... Cohen Veterans Bioscience and Early Signal Foundation announce a ... sensors for real-time monitoring of patients with trauma-related and ... focused on disruptive health solutions for rare disorders and ... record and integrate behavioral, cognitive, physiological and contextual data. ... ...
(Date:9/25/2017)... R.I. , Sept. 25, 2017  EpiVax, ... assessment, vaccine design, and immune-engineering today announced the ... on the development of personalized therapeutic cancer vaccines. ... has provided exclusive access to enabling technologies to ... Eng., MBA will lead EpiVax Oncology as Chief ...
Breaking Medicine Technology: