Navigation Links
Mechanism explains complex brain wiring
Date:6/11/2014

How neurons are created and integrate with each other is one of biology's greatest riddles. Researcher Dietmar Schmucker from VIB-KU Leuven unravels a part of the mystery in Science magazine. He describes a mechanism that explains novel aspects of how the wiring of highly branched neurons in the brain works. These new insights into how complex neural networks are formed are very important for understanding and treating neurological diseases.

Neurons, or nerve cells

It is estimated that a person has 100 billion neurons, or nerve cells. These neurons have thin, elongated, highly branched offshoots called dendrites and axons. They are the body's information and signal processors. The dendrites receive electrical impulses from the other neurons and conduct these to the cell body. The cell body then decides whether stimuli will or will not be transferred to other cells via the axon.

The brain's wiring is very complex. Although the molecular mechanisms that explain the linear connection between neurons have already been described numerous times, little is as yet known about how the branched wiring works in the brain.

The connections between nerve cells

Prior research by Dietmar Schmucker and his team lead to the identification of the Dscam1 protein in the fruit fly. The neuron can create many different protein variations, or isoforms, from this same protein. The specific set of isoforms that occurs on a neuron's cell surface determines the neuron's unique molecular identity and plays an important role in the establishment of accurate connections. In other words, it describes why certain neurons either come into contact with each other or reject each other.

Recent work by Haihuai H and Yoshiaki Kise from Dietmar's team indicates that different sets of Dscam1 isoforms occur inside one axon, between the newly formed offshoots amongst each other. If this was not the case, then only linear connections could
'/>"/>

Contact: Dietmar Schmucker
dietmar.schmucker@vib-kuleuven.be
32-163-73222
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Page: 1 2

Related medicine news :

1. MAD: Scientists shed light on braking mechanisms in cellular signaling
2. Mechanisms of ibrutinib resistance identified in chronic lymphocytic leukemia
3. Major discovery on the mechanism of drug resistance in leukemia and other cancers
4. Researchers identify key mechanism in metabolic pathway that fuels cancers
5. Supermodel mouse reveals mechanisms that regulate metabolism, researchers find
6. Scientists decode epigenetic mechanisms distinguishing stem cell function and blood cancer
7. Study identifies mechanism by which intestinal enzyme maintains microbial balance
8. Vascular simulation research reveals new mechanism that switches in disease
9. GW researcher discovers the mechanisms that link brain alertness and increased heart rate
10. Researchers identify mechanism of cancer caused by loss of BRCA1 and BRCA2 gene function
11. Depressed? Researchers identify new anti-depressant mechanisms, therapeutic approaches
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... The Biofeedback Federation of Europe annual meeting ... Rome, Italy and is hosted by the Salesian Pontifical ... a wide variety of topics such as ADHD, anxiety, ... in athletes. The scientific program will feature the latest ... allows clients to see what is going on in ...
(Date:12/26/2014)... December 26, 2014 DW-InductionHeating.com (DaWei Induction ... designing, researching and developing, producing and marketing of a ... the business announces their new series of induction ... of the company, induction brazing refers to ... special filler material and heat. The manager says that ...
(Date:12/25/2014)... 26, 2014 The report “Nintedanib ... 2023” focuses on the current treatment landscape, unmet ... colorectal cancer market. Stivarga is a drug which ... rectal cancer. Boehringer Ingelheim is developing nintedanib (BIBF-1120), ... of refractory CRC in the US, Europe, and ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... 2014 When head lice hits a home ... frenzy to get rid of it while keeping it from ... Gables now have the solution right in their neighborhood: ... Lice Troopers provides full spectrum head lice screening and treatment ... including Sunset, Key Biscayne, Brickell, Coconut Grove, Kendall, Pinecrest and ...
Breaking Medicine News(10 mins):Health News:Final Workshop Line-up Announced for 18th Annual Biofeedback Conference in Rome, Italy 2Health News:Induction Brazing Equipment Series From DaWei Induction Heating Co., A Reliable Supplier Of Induction Heating Equipment 2Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 4Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2
... ... on How to Help the Ones We Love and Care For , ... New York City (PRWEB) July 2, 2010 ... prevention hotline has just released a free Internet guide in response to these desperate times ...
... ... grade food supplements from manufacturers with the best reputations with alternative practitioners. After more ... is expanding its inventory to include a range of health and wellness items. ... (PRWEB) July ...
... ... and liposuction system that is dependable and affordably-priced. , ... Louisville, KY (Vocus) July 2, 2010 -- DRE, ... , an affordable aspirator and liposuction system that features two positive displacement pumps and ...
... ... , ... 2010 -- The Back to School shopping season has become one of the top three ... many businesses are looking for a way to get more potential customers into their stores ...
... , ... New Chair of Board , ... Lakewood Ranch, Fla. -- ShelterBox USA, an international aid organization that provides shelter and life-saving ... the Board of Directors at the close of its fiscal year June 30, where ShelterBox ...
... ARBOR, Mich. Black people with cancer are up ... from their disease. While disparities exist for nearly every ... that benefit most from treatment -- suggesting that black ... a review from researchers at the University of Michigan ...
Cached Medicine News:Health News:Saving Lives in Desperate Times 2Health News:Saving Lives in Desperate Times 3Health News:Vitamins for Life Inventory Extended to Wellness Products, Higher Nature Supplements 2Health News:Vitamins for Life Inventory Extended to Wellness Products, Higher Nature Supplements 3Health News:DRE Introduces Economically-Priced Liposuction System 2Health News:DRE Introduces Economically-Priced Liposuction System 3Health News:Giant Crayon Sweepstakes Giveaway Helps Businesses Increase Traffic for Back to School Promotions 2Health News:ShelterBox USA Grows by 1000 Percent 2Health News:ShelterBox USA Grows by 1000 Percent 3Health News:Why are blacks more likely to die from cancer diagnosis? 2
(Date:12/24/2014)... DUBLIN and RALEIGH, N.C. ... subsidiary of Endo International plc (NASDAQ: ENDP ... BDSI ) announced today that they have ... Buccal Film to the U.S. Food and Drug Administration ... the management of pain severe enough to require daily, ...
(Date:12/22/2014)... Dec. 22, 2014  CytoSorbents Corporation (OTCQB:CTSOD), a ... blood purification technology to help fight deadly inflammation ... countries worldwide, today announced the appointment of Dr. ... as its Senior Vice President of Clinical Development, ... Di Russo is an accomplished pediatric ...
(Date:12/22/2014)... , Dec. 22, 2014 Apnea Sciences ( ... offices in Aliso Viejo , California.  ... to the tremendous growth and worldwide expansion, a new ... patented SnoreRx, the anti snore cure have exceeded our ... "We are now in 23 countries and will ...
Breaking Medicine Technology:Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 2Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 3Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 4Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 5CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 3CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 4CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 5
... of the Creighton University School of Medicine presented a ... of Clinical Oncology (ASCO) Annual Symposium, June 5th in ... in Gynecologic Cancer Detected by an In Vitro Assay, ... Drug Response Marker test results taken in the primary ...
... Holdings Inc. ("Ore") announced today that, pursuant to the ... of Directors of Ore (the "Board") approved and authorized ... of Ore,s common stock, $0.01 par value (the "Common ... necessary to receive at least one share of post-split ...
Cached Medicine Technology:Precision Therapeutics Presents Clinical Study Emphasizing the Role of ChemoFx® in Directing Chemotherapy in Gynecological Cancers 2Ore Pharmaceutical Holdings Announces Name Change and Reverse/Forward Stock Split to be Effective June 10, 2011 2Ore Pharmaceutical Holdings Announces Name Change and Reverse/Forward Stock Split to be Effective June 10, 2011 3
... A fixed pipette is ... a single volume. Fixed volume ... and advantages as other Finnpipette ... design, Super blow-out (1-40ul), Soft-touch ...
Pipetman F is a fixed-volume, air-displacement pipette. Thirteen robust models cover a large volume range from 2 L to 1000 L, with Gilsons legendary accuracy and precision....
Inquire...
... fixed pipette is ideal for ... volume. Fixed volume FInnpipettes offer ... as other Finnpipette Digital pipettes: ... blow-out (1-40ul), Soft-touch tip ejection, ...
Medicine Products: