Navigation Links
Mechanism discovered by which body's cells encourage tuberculosis infection
Date:12/10/2009

ility of blocking or inhibiting molecular mechanisms in the body to prevent or treat infectious diseases as well. "

Earlier studies in the zebrafish by the Ramakrishnan lab demonstrated that TB tubercles were not, as previously thought, the way that the body walls off the bacteria to protect itself. Instead, these nodules (also called granulomas) are hubs for bacteria production and distribution. Uninfected macrophages the body's frontline soldiers that can eat and destroy many bacteria are recruited to the nodules, where they become TB-infected. However, the TB bacteria are able to grow in the macrophages, rather than being killed, likely by dampening the macrophages' defenses.

So by wooing more macrophages into the granuloma, the bacteria can use them to expand further. Some germ-laded macrophages then move to a new location, where they again attract more macrophages. New tubercles form and the scene is repeated.

Ramakrishnan and her research team have identified a molecular mechanism by which the mycobacteria that cause TB induce the body to form these production and distribution nodules. Researchers have long known that TB virulence is associated with a small protein the bacteria secrete, called ESAT-6.

Ramakrishan's group now has found that this secreted bacterial protein induces epithelial cells the cells that make up membranous tissue covers inside the body to produce an enzyme called MMP9. This enzyme has many functions including breaking down gelatin a connective tissue protein -- into its components. In people, the presence of MMP9 is associated with increased susceptibility to infection and worse outcomes. The findings of this new study explain why this might be the case. MMP9 is also implicated in the development of several non-infectious inflammatory conditions, like arthritis, as well as heart disease and cancer.

Epithelial cells were once thought to be bystanders as tuberculosis took hold, accordin
'/>"/>

Contact: Leila Gray
leilag@u.washington.edu
206-685-0381
University of Washington
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Researchers uncover novel mechanism that balances the sizes of functional areas in the brain
2. UCSD study reveals the regulatory mechanism of key enzyme
3. Ancient mechanism for coping with stresses also gives cancer a boost
4. UCSD study reveals the regulatory mechanism of key enzyme
5. Researchers at IRB Barcelona discover one of the mechanisms that prevents the spread of colon cancer
6. Researchers chart the genetic mechanisms behind the genesis of fat cells
7. Research suggests mechanism for acne drugs link to depression
8. St. Jude finds mechanism for faulty protein disposal
9. St. Jude Finds Mechanism for Faulty Protein Disposal
10. Study suggests nicotine addiction might be controlled by influencing brain mechanisms
11. Quality control mechanism tags defective sperm cells inside the body
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mechanism discovered by which body's cells encourage tuberculosis infection
(Date:1/22/2015)... New York, NY (PRWEB) January 22, 2015 ... American College of Sports Medicine flagship journal Medicine ... supplementation with L-Citrulline before exercise may help reduce ... strenuous exercise. 1 , Participants in the ...
(Date:1/22/2015)... 2015 Recently, Weddingshe.com has added many trendy ... announced its highest annual revenues in the past three years. ... glamorous wedding dresses. , According to the sales manager of ... promotions for them in 2015. This point can be reflected ...
(Date:1/22/2015)... 22, 2015 Four years since the release of ... coincided with the marriage of Avasa & Matthew Love – the ... is scheduled for release through White Swan Records on February 24, ... is a sacred path available to all of us to walk ...
(Date:1/22/2015)... EBSCO Information Services (EBSCO) and the ... an effort to further promote visibility and adoption of the ... made AMA journals available via its subscription services, EBSCO will ... , Long known as both a subscription agency ...
(Date:1/22/2015)... January 22, 2015 JJsHouse.com is a famous ... Today, the business announces its latest collection of wedding ... “The most important issue is the wedding dress on your ... in a woman’s life. Every bride wants to find the ...
Breaking Medicine News(10 mins):Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4Health News:Find The Most Suitable Wedding Dress At JJsHouse.com 2
... administration, planning to make the city 'smoke-free' from July, Wednesday ... a meeting of the committee set up to work out ... was decided to empower police officials of the rank of ... by recovering the penalty from the offender on the spot. ...
... confessed to aborting over 250 female fetuses, adding he has lost ... his nursing home over the last decade. ,A.K. Singh ... in Pataudi town near here and discovered the dumped fetuses from ... has confessed that he has aborted more than 250 unborn female ...
... IT business unit of India's Wipro Ltd with presence ... an eco-friendly range of desktops and laptops that ... ,The new range of products, christened Wipro GreenWare, is ... ,The $3-billion IT bellwether has set up an ...
... plight of a one-year-old child whose leg had been ... High Court has asked the government and hospital authorities ... to his parents for his upbringing. ,Taking suo ... of Justices T.S. Thakur and S.N. Aggarwal earlier this ...
... reason behind her dramatic weight loss over the past few months, ... reason. ,Jolie told reporters at the New York ... shes lost weight is because shes not only still grieving over ... cancer in January, but also busy running around four young kids. ...
... new study by University of Illinois researchers describes how ... pathology of type 2 diabetes . ,Published ... a number of cytokines, protein signals that bind to ... of biochemical reactions within the cell. ,Interleukins, ...
Cached Medicine News:Health News:Quack of Gurgaon Confesses of Aborting 250 Female Fetuses 2Health News:Child Seeks Compensation for Medical Negligence 2Health News:Cytokine Resistance Contributes to Pathology of Type 2 Diabetes 2
(Date:1/23/2015)... BIRMINGHAM, Ala. , Jan. 23, 2015 Gem ... (STS) patients have been enrolled into the Company,s Phase ... efficacy and safety of Gem,s lead compound, GPX-150 (an ... for advanced or metastatic disease. Logo - ...
(Date:1/22/2015)... BOULDER, Colo. , Jan. 22, 2015  BiOptix is ... Klakamp as Vice President of Chemistry and Biochemistry. Scott ... Takeda Pharmaceuticals, AstraZeneca Pharmaceuticals, and Amgen throughout the course ... and development. "Scott is a nationally recognized ...
(Date:1/22/2015)... AMGN ) today announced that it will report its ... 27, 2015, after the close of the U.S. financial markets. The ... community at 2 p.m. PT. Participating in the call from Amgen ... officer, and other members of Amgen,s senior management team. ...
Breaking Medicine Technology:Gem Pharmaceuticals Announces Enrollment of Initial Patients in its Phase 2 Clinical Trial to Assess the Efficacy and Safety of GPX-150 in Sarcoma Patients 2BiOptix Expands Leadership Team with the Appointment of Dr. Scott Klakamp as Vice President of Chemistry and Biochemistry 2Amgen Announces Webcast of 2014 Fourth Quarter and Full Year Financial Results 2
... Jan. 14, 2011   The Cleveland Clinic and Valence ... the Clinic,s effort to become a clinically integrated network. ... the Cleveland Clinic Hospitals, physicians, and more than 1,000 ... Clinic, through its Community Physician Partnership (CPP), recognized the ...
... 2011 New Product Planning (NPP) groups play a vital ... set the stage for a successful launch. One of the ... activities such as ad boards, and thought leader identification and ... New Product Planning: Role and Activities for Medical Affairs ...
Cached Medicine Technology:Valence Health Selected by Cleveland Clinic to Support Clinical Integration Program 2Best Practices, LLC Research Highlights Critical Role of Medical Affairs in New Product Launch Success 2
Conducting disposable tips provide cross-contaminationfree pipetting for sensitive applications such as PCR setup....
... to optimize the accuracy and precision of ... is widely recognized by customers throughout the ... over the years and now covers a ... including filter tips, certified pure tips, stepper ...
... the Finntip Wide is designed especially for ... genomic DNA. This tip eliminates the mechanical ... excellent for use with extremely viscous liquids. ... of the orifice is 1.1 mm or ...
Capillary section fits into a 0.3-mm well for accurate loading of sequencing gels...
Medicine Products: