Navigation Links
Mechanism behind compound's effects on skin inflammation and cancer progression
Date:5/23/2011

Boston, MA - Charles J. Dimitroff, MS, PhD and colleagues in the Dimitroff Lab at Brigham and Women's Hospital, have developed a fluorinated analog of glucosamine, which, in a recent study, has been shown to block the synthesis of key carbohydrate structures linked to skin inflammation and cancer progression. These findings appear in the April 14, 2011, issue of the Journal of Biological Chemistry.

Dr. Dimitroff and colleagues show for the first time that the fluorinated glucosamine therapeutic works not through direct incorporation into growing sugar chains as previously believed but instead blocks the synthesis of a key sugar, UDP-GlcNAc, inside immune cells characteristically involved inflammation and anti-tumor immunity

Accordingly, this report underscores a novel and previously unknown mechanism by which fluorinated glucosamine analogs could shape and reduce inflammation intensity, while boosting anti-tumor immune responses. Such knowledge could prove valuable in the design of new and more potent glucosamine mimetics against disease as well as in treatment strategies to utilize existing glucosamine mimetics more efficiently.


'/>"/>

Contact: Holly Brown-Ayers
hbrown-ayers@partners.org
617-534-1603
Brigham and Women's Hospital
Source:Eurekalert

Page: 1

Related medicine news :

1. The peculiar feeding mechanism of the first vertebrates
2. Researchers discover underlying mechanisms of skin hardening syndromes
3. New mitochondrial control mechanism discovered
4. Researchers discover mechanism that could convert certain cells into insulin-making cells
5. Researchers identify novel pathophysiologic mechanism responsible for autoimmunity
6. Signaling pathway reveals mechanism for B cell differentiation in immune response
7. Mechanism for esophageal cancer uncovered
8. Mechanism for invasion of tumorous cells discovered by Hebrew University researchers
9. Mount Sinai finds promising clue to mechanism behind gene mutation that causes Parkinsons disease
10. Scientists find key mechanism of childhood respiratory disease
11. Novel mechanism for control of gene expression revealed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... Naples, Florida (PRWEB) December 22, 2014 ... this holiday season, the gift of health and vitality. ... is offering its three top-selling anti-aging formulas in special ... with free rush delivery. , Each bottle contains ... digestion, areas that don't work as well as we ...
(Date:12/22/2014)... 2014 Xarelto Lawsuit News : ... judges has granted a request to centralize pending and ... Court, Eastern District of Louisiana. The U.S. Judicial Panel ... 12 to transfer over 50 Xarelto cases–21 lawsuits and ... Louisiana court for consolidation under U.S. District Judge Eldon ...
(Date:12/22/2014)... December 22, 2014 Christmas is days away, ... a fast and easy solution that will please: the ... be purchased from from $25 up to $350," says Kathy ... customer satisfaction and a wide array of skin care products ... and no expiration dates. , Gift delivery past shipping ...
(Date:12/22/2014)... The NLN’s 2015 Leadership ... this month. Faculty have been selected through competitive ... fast-tracked for administrative leadership roles within their academic ... Simulation Educators, featuring a curriculum uniquely devised for ... , Twenty nurse educators were chosen for ...
(Date:12/21/2014)... Recently, BambooFlooringChina.com, a famous bamboo lumber supplier, has ... and launched a bamboo flooring promotion with great discounts, ... 30, 2015. , According to the CEO of the ... available today; it has a highly distinctive grain with ... woven bamboo is made by a unique manufacturing process ...
Breaking Medicine News(10 mins):Health News:You Still Have Time to Give the Gift of Health and Vitality to a Mature Loved One 2Health News:Panel Orders Xarelto Lawsuits Consolidated Into Multi-District Litigation Reports Alonso Krangle LLP 2Health News:Panel Orders Xarelto Lawsuits Consolidated Into Multi-District Litigation Reports Alonso Krangle LLP 3Health News:Panel Orders Xarelto Lawsuits Consolidated Into Multi-District Litigation Reports Alonso Krangle LLP 4Health News:NLN Leadership Institute Announces 2015 Cohorts 2Health News:NLN Leadership Institute Announces 2015 Cohorts 3Health News:BambooFlooringChina.com Announced Its Durable Strand Woven Bamboo Flooring Collection 2
... governing the private educational institutions in the state in ... cabinet decided to adopt the new rules for the ... said here. ,The school managements will now ... prescribed and timely salaries to teaching and non-teaching staff ...
... drink and the sparkle of many a party. That apart, wine ... a health drink, known to sustain cardiovascular// health and keep age ... health, it is cheers to a copious flow of health benefits. ... wine is considered sacrosanct, alluding to the blood of Christ, which ...
... Chapel Hill suggested that low LDL values can increase ... for low density lipoprotein; the low values of LDL ... been made between LDL and cardiovascular diseases, smoking and ... a lower occurrence of heart attack and stroke than ...
... “trans fat” leaves a bad taste in the mouths ... for health, but// scientists at the University of Arkansas ... by juggling the molecular structure of soy oil. ... student Vishal Jain produced soy oil rich in conjugated ...
... are the best ways to prevent the most common types ... paediatricians.// ,Kidney stones are rarely a serious condition, ... infections. Signs and symptoms of kidney stones include intense pain ... painful urination, blood in the urine and/or cloudy urine, urinary ...
... progression of Alzheimer's disease (AD) according to a study ... is one// in a group of related steroid hormones ... published in the December 20 issue of The Journal ... testosterone loss and AD, which affects 4.5 million Americans. ...
Cached Medicine News:Health News:Celebrating Christmas With Wine – The Elixir of the God 2Health News:Celebrating Christmas With Wine – The Elixir of the God 3Health News:Low LDL Levels Lead to Parkinson's Disease 2Health News:Healthy Potato Chips: A Trans Fat Oil With Health Benefits 2Health News:Drinking Plenty of Water may Prevent Kidney Stones 2Health News:Increase Testosterone Levels To Slow Down Alzheimer’ 2
(Date:12/22/2014)... -- Cyberonics, Inc. (NASDAQ: CYBX ), a global ... epilepsy, today announced it will participate in the 33 rd ... 2015, in San Francisco . ... will speak at 11:00 AM Pacific Time.  A live audio ... the Investor Relations link on the Cyberonics home page at ...
(Date:12/22/2014)... , Dec. 22, 2014 /PRNewswire/ -- RXi Pharmaceuticals ... company focused on discovering, developing and commercializing innovative ... technologies, today issued the following open letter to ... , Dr. Med. Sc. Dear RXi ... a number of inaccurate statements posted on certain ...
(Date:12/22/2014)... Calif. , Dec, 22, 2014  Eiger ... Phase 2a study of lonafarnib in patients with ... was conducted at the National Institutes of Health ... .  The double-blinded, randomized, placebo-controlled, dose ascending ... twice daily and 200 mg twice daily for ...
Breaking Medicine Technology:RXi Pharmaceuticals Issues Open Letter to Shareholders 2RXi Pharmaceuticals Issues Open Letter to Shareholders 3RXi Pharmaceuticals Issues Open Letter to Shareholders 4RXi Pharmaceuticals Issues Open Letter to Shareholders 5RXi Pharmaceuticals Issues Open Letter to Shareholders 6Eiger Bio Announces Positive Data in Patients Infected with Hepatitis Delta Virus (HDV) Treated with Lonafarnib - Results Presented at American Association for the Study of Liver Diseases (AASLD) Meeting 2Eiger Bio Announces Positive Data in Patients Infected with Hepatitis Delta Virus (HDV) Treated with Lonafarnib - Results Presented at American Association for the Study of Liver Diseases (AASLD) Meeting 3
... LOUIS, May 4, 2011 Stereotaxis, (Nasdaq: ... a broad spectrum of complex arrhythmias will again be ... Annual Heart Rhythm Scientific Sessions in San Francisco, California. ... data and discussions of the value of magnetic navigation ...
... At the Board of Directors meeting held today, the ... The dividend is payable on June 15, 2011 to shareholders ... About Sigma-Aldrich: Sigma-Aldrich is a leading Life Science ... the Quality of Life. Its chemical and biochemical products and ...
Cached Medicine Technology:Stereotaxis' Continued Leadership in Scientific Outcome Data Prominently Displayed with Multiple Key Presentations at HRS 2011 2Stereotaxis' Continued Leadership in Scientific Outcome Data Prominently Displayed with Multiple Key Presentations at HRS 2011 3Stereotaxis' Continued Leadership in Scientific Outcome Data Prominently Displayed with Multiple Key Presentations at HRS 2011 4Stereotaxis' Continued Leadership in Scientific Outcome Data Prominently Displayed with Multiple Key Presentations at HRS 2011 5
... The GENIE is the proven electrophoretic transfer ... in field uniformity. Its design allows for a ... coupled with a low voltage power source such ... in volts/cm. The result is exceptionally rapid and ...
... Trans-Blot cell, a component of Bio-Rad's modular ... provides rapid, high-quality blotting of mini gels. ... x 10 cm gels in just 1 ... cooling unit, which absorbs heat generated during ...
... Includes PowerPac 200 power ... Range of Parameters. Quantitative Transfers. ... or Overnight Transfers. Faster, ... High Field-Intensity Transfers with ...
... gel holder cassettes, cell with ... pads, blot absorbent paper (15 ... transfer cell, used with the ... efficient, high-intensity electrophoretic transfers. The ...
Medicine Products: