Navigation Links
Mechanism behind compound's effects on skin inflammation and cancer progression
Date:5/23/2011

Boston, MA - Charles J. Dimitroff, MS, PhD and colleagues in the Dimitroff Lab at Brigham and Women's Hospital, have developed a fluorinated analog of glucosamine, which, in a recent study, has been shown to block the synthesis of key carbohydrate structures linked to skin inflammation and cancer progression. These findings appear in the April 14, 2011, issue of the Journal of Biological Chemistry.

Dr. Dimitroff and colleagues show for the first time that the fluorinated glucosamine therapeutic works not through direct incorporation into growing sugar chains as previously believed but instead blocks the synthesis of a key sugar, UDP-GlcNAc, inside immune cells characteristically involved inflammation and anti-tumor immunity

Accordingly, this report underscores a novel and previously unknown mechanism by which fluorinated glucosamine analogs could shape and reduce inflammation intensity, while boosting anti-tumor immune responses. Such knowledge could prove valuable in the design of new and more potent glucosamine mimetics against disease as well as in treatment strategies to utilize existing glucosamine mimetics more efficiently.


'/>"/>

Contact: Holly Brown-Ayers
hbrown-ayers@partners.org
617-534-1603
Brigham and Women's Hospital
Source:Eurekalert

Page: 1

Related medicine news :

1. The peculiar feeding mechanism of the first vertebrates
2. Researchers discover underlying mechanisms of skin hardening syndromes
3. New mitochondrial control mechanism discovered
4. Researchers discover mechanism that could convert certain cells into insulin-making cells
5. Researchers identify novel pathophysiologic mechanism responsible for autoimmunity
6. Signaling pathway reveals mechanism for B cell differentiation in immune response
7. Mechanism for esophageal cancer uncovered
8. Mechanism for invasion of tumorous cells discovered by Hebrew University researchers
9. Mount Sinai finds promising clue to mechanism behind gene mutation that causes Parkinsons disease
10. Scientists find key mechanism of childhood respiratory disease
11. Novel mechanism for control of gene expression revealed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... ... , ... For those who skip meals occasionally (which is pretty much everyone), ... many new lifestyle diet tips offered by nutritionists Pam Bonney and Priya Lawrence of ... show. Bonny and Lawrence noted that because proper nutrition, including water, provides energy during ...
(Date:4/29/2016)... FL (PRWEB) , ... April 29, 2016 , ... ... will feature Grassland Dairy Products, Inc. in an upcoming episode, airing third quarter ... a century of churning cream into butter, Grassland Dairy Products, located in Greenwood, ...
(Date:4/29/2016)... PLAINSBORO, N.J. (PRWEB) , ... April 29, 2016 ... ... consumer digital and print media enterprise focused entirely on patients with cancer, today ... Mirage, California, was chosen as the 2016 CURE® Extraordinary Healer® for Oncology ...
(Date:4/29/2016)... CA (PRWEB) , ... April 29, 2016 , ... Nike ... long softball camp from July 24th – 27th for girls aged 10-18. All facets ... is held at the beautiful Clark V. Whited Complex, one of the finest softball ...
(Date:4/29/2016)... (PRWEB) , ... April 29, 2016 , ... International Dehydrated ... Seminar on May 3 and 4 at the Doubletree by Hilton Hotel in Oak ... dedicated to marketing and applications technologies for protein ingredients. , At the seminar, IDF™ ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... JERUSALEM , April 28, 2016 ... ), a clinical-stage pharmaceutical company focused on the development of ... participate in the upcoming PIONEERS 2016 conference, presented by ... 5, 2016 in New York . ... overview at the conference. Presentation Details:   ...
(Date:4/28/2016)... , April 28, 2016  ValGenesis, Inc., ... Management Solutions (VLMS) today announced that a ... for sufferers of chronic kidney failure has ... manage their corporate validation process. The global ... software solution to manage their validation processes ...
(Date:4/28/2016)... , April 28, 2016 ... Review, H1 2016" is a report that provides ... helps strengthen R&D pipelines by identifying new targets ... Company Profiles discussed in this H1 ... Farmaceutiche Riunite Srl, AbbVie Inc., Abiogen Pharma S.p.A., ...
Breaking Medicine Technology: