Navigation Links
Mechanism behind compound's effects on skin inflammation and cancer progression
Date:5/23/2011

Boston, MA - Charles J. Dimitroff, MS, PhD and colleagues in the Dimitroff Lab at Brigham and Women's Hospital, have developed a fluorinated analog of glucosamine, which, in a recent study, has been shown to block the synthesis of key carbohydrate structures linked to skin inflammation and cancer progression. These findings appear in the April 14, 2011, issue of the Journal of Biological Chemistry.

Dr. Dimitroff and colleagues show for the first time that the fluorinated glucosamine therapeutic works not through direct incorporation into growing sugar chains as previously believed but instead blocks the synthesis of a key sugar, UDP-GlcNAc, inside immune cells characteristically involved inflammation and anti-tumor immunity

Accordingly, this report underscores a novel and previously unknown mechanism by which fluorinated glucosamine analogs could shape and reduce inflammation intensity, while boosting anti-tumor immune responses. Such knowledge could prove valuable in the design of new and more potent glucosamine mimetics against disease as well as in treatment strategies to utilize existing glucosamine mimetics more efficiently.


'/>"/>

Contact: Holly Brown-Ayers
hbrown-ayers@partners.org
617-534-1603
Brigham and Women's Hospital
Source:Eurekalert

Page: 1

Related medicine news :

1. The peculiar feeding mechanism of the first vertebrates
2. Researchers discover underlying mechanisms of skin hardening syndromes
3. New mitochondrial control mechanism discovered
4. Researchers discover mechanism that could convert certain cells into insulin-making cells
5. Researchers identify novel pathophysiologic mechanism responsible for autoimmunity
6. Signaling pathway reveals mechanism for B cell differentiation in immune response
7. Mechanism for esophageal cancer uncovered
8. Mechanism for invasion of tumorous cells discovered by Hebrew University researchers
9. Mount Sinai finds promising clue to mechanism behind gene mutation that causes Parkinsons disease
10. Scientists find key mechanism of childhood respiratory disease
11. Novel mechanism for control of gene expression revealed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/28/2017)... ... June 28, 2017 , ... The ... for excellence in employee engagement. Omaha-based C&A Industries, a national leader in ... Engaged Workplaces™ in North America for 2017. The annual award, issued ...
(Date:6/28/2017)... ... 2017 , ... Anyone with a remote control has seen the never-ending twists on the house ... will get rich in no time. But what about the buyers of the flipper's ... buyer of a flipped house. An email recently sent to Gary Case said, “Just ...
(Date:6/28/2017)... ... 28, 2017 , ... Park Systems , a leader in Atomic Force ... attendees and Park customers on July 11, 2017 from 12-2pm at the Thirsty ... & CEO of Park Systems, and Prof. Krishna Saraswat , Rickey/Nielsen Professor in ...
(Date:6/28/2017)... ... June 28, 2017 , ... ... servicing communities throughout the greater Cincinnati metropolitan area, is teaming up with the ... for families with children receiving treatment in nearby hospitals. , Ronald McDonald House ...
(Date:6/27/2017)... Orlando, FL (PRWEB) , ... June 27, 2017 ... ... the leading payment solution for many of the health care industry’s hospitals and ... its new patient financing portal for select customers. Parasail Health is a San ...
Breaking Medicine News(10 mins):
(Date:6/5/2017)... 2017 Kohll,s Pharmacy & Homecare is the first distributor ... States . The Raizer is a simple battery operated ... to an almost-standing position within a few minutes. ... assistant and does not require any extra effort besides ... child can operate it, and lightweight and portable ...
(Date:5/30/2017)... Hill-Rom Holdings, Inc. (NYSE: HRC), will present at the Goldman ... June 13, 2017, in Rancho Palos Verdes, California ... executive officer, is scheduled to present at 3:20 p.m. Pacific ... at http://ir.hill-rom.com/events.cfm . A recorded replay will be available ... 13, 2017. About ...
(Date:5/24/2017)... HAMPTON, Va. , May 24, 2017 /PRNewswire/ ... ivWatch Original Equipment Manufacturer (OEM) Board to enable ... technology with patient monitoring systems, infusion pumps and ... products, OEMs will be able to help health ... care and reduced risks related to IV therapy. ...
Breaking Medicine Technology: